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Prostate Cancer

Minimally invasive surgical options provide a better patient experience through a number of benefits:

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Urology is the surgical specialty concerned with correcting abnormalities of the genitourinary system in both men and women. A urologist may use medical treatment or resort to surgery to correct these abnormalities. Surgery is often necessary to remove a genitourinary organ affected by cancer. Dr. Lesani has a special interest in treating men and women with cancers of the kidney as well as men with prostate cancer.

He adheres to the philosophy that "It is not the cancer you remove from the patient but rather it is the patient you preserve from cancer."

Dr. Alex Lesani is the only urologist in Southern Nevada with fellowship training in laparoscopy and robotic surgery. He utilizes cutting-edge minimally invasive techniques to treat patients with urologic disease especially those suffering from cancer. Dr. Lesani believes if the patients are made aware of modern, less invasive options, which offer equivalent or superior results and lead to earlier recovery compared to traditional surgery, the patients would prefer these options. Take time and explore this web site and understand your treatment options.

Comparative analysis of transperineal template-saturation prostate biopsy versus MRI-targeted biopsy with MRI-US fusion-guidance

Multiparametric-MRI (mp-MRI) and MRI-targeted biopsy may improve detection of clinically significant prostate cancer (PCa). However, standardized prospective evaluation is limited.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Improved Outcomes Owing to High-intensity Focused Ultrasound Devices Version-up for the Treatment of Patients with Localized Prostate Cancer

To evaluate the association between long-term clinical outcomes and morbidity of high-intensity focused ultrasound (HIFU).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Preoperatively Misclassified, Surgically Removed Benign Renal Masses: A Systematic Review of Surgical Series and United States Population-Level Burden Estimate

A significant proportion of renal masses removed for suspected malignancy are histologically benign, with probabilities inversely proportional to lesion size. The number of preoperatively misclassified benign renal masses (BRM) undergoing nephrectomy is currently unknown. Given the increasing incidence and decreasing average size of renal cell carcinoma (RCC), this burden is likely increasing. The purpose of this study is to estimate the population-level burden of surgically removed, preoperatively misclassified BRM in the US.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Mortality after bladder augmentation in childhood in patients with spina bifida

Renal failure has been a leading cause of death for children with spina bifida (SB). Improvements in management have improved survival, but data on mortality in the modern medical era is sparse. Bladder augmentation, a modern intervention to preserve renal function, carries risks of morbidity and mortality. Our goal is to determine long-term mortality and causes of death in patients with SB and bladder augmentation in the modern era.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

High Regional Variation in Urethroplasty Utilization in the United States

To identify clinical and regional factors associated with utilization of urethroplasty versus repeated endoscopic management for urethral stricture disease.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

New Modalities for the Evaluation and Surveillance of Complex Renal Cysts

The increased use of abdominal imaging has led to an increase in the detection of incidental renal cysts. Since the inception of the Bosniak classification system, the management of Bosniak I, Bosniak III and Bosniak IV cysts has been clearly defined, while the evaluation and management of Bosniak II and IIF cysts has remained a clinical dilemma. In recent years, discussions on new imaging modalities have become prevalent in the radiologic literature. In this context, we performed a comprehensive review of the recent literature on complex renal cysts focusing on new imaging modalities, surveillance strategies and biopsy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Biofeedback for Non-neuropathic daytime voiding disorders in children: A systematic review and meta-analysis of randomized controlled trials

Biofeedback has been used to treat children with symptoms of bladder dysfunction not responding to standard therapy alone. However, the evidence of the effectiveness is scarce and based on small studies. We conducted a systematic review of the literature to assess the effects of biofeedback as an adjunctive therapy for symptoms of Non-neuropathic voiding disorders (NVD) in children up to the age of 18.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Feasibility of intraoperative navigation to the sentinel node in the groin using preoperatively acquired SPECT/CT data; transferring functional imaging to the operating room

To explore the clinical feasibility and accuracy of intraoperative navigation based on preoperatively acquired 3D functional imaging data.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Bladder reinnervation using a primarily motor donor nerve (femoral nerve branches) is functionally superior to using a primarily sensory donor nerve (genitofemoral nerve)

To determine whether transfer of a primarily motor nerve (Femoral, F) to the anterior vesicle branch of the pelvic nerve (PN) allows more effective bladder reinnervation than a primarily sensory nerve (genitofemoral, GF).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Comparison of Transvaginal and Retropubic Bladder Neck Closure with Suprapubic Catheter in Women

Bladder neck closure (BNC) is an uncommon procedure that is usually reserved for patients with severe urethral incompetence and may be an acceptable alternative to procedures involving bowel reconstruction. BNC can be performed using a transvaginal (TV) or retropubic (RP) approach. The purpose of the study was to compare the urethral continence rates, peri-operative outcomes, short-term and long-term complications, subsequent procedures, and change in renal function between TV and RP BNC in females at our institution.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prostate capsule sparing versus nerve sparing radical cystectomy for bladder cancer: Results from a randomized controlled trial

Prostate capsule sparing and nerve sparing cystectomies are alternative procedures for bladder cancer that may reduce morbidity while achieving cancer control. However, the comparative effectiveness of these approaches has not been established. We sought to evaluate the functional and oncologic outcomes of patients undergoing these two procedures.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Donation After Cardiac Death Pediatric En-Bloc Renal Transplantation

The use of small pediatric kidneys obtained from very young donors after cardiac death (DCD) has been limited and this remains an underutilized organ source.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A prospective randomized comparison between Shock wave lithotripsy(SWL), Retrograde intrarenal surgery(RIRS) and miniperc for treatment of 1-2 cm radiolucent lower calyceal renal calculi :A single centre experience

A prospective randomized comparison of Shock wave lithotripsy(SWL), retrograde intrarenal surgery(RIRS) and miniperc for treatment of 1-2cm radiolucent lower calyceal renal calculi was done to evaluate safety and efficacy of these procedures.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Impact of Family History on Prostate Cancer Mortality in Caucasian Men Undergoing PSA-Based Screening

To assess if prostate cancer (PCa) screening reduces PCa mortality in Caucasian men with a family history (FH) of prostate cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

AMS 700 reservoir alternate surgical implantation technique: preliminary outcomes for initial Prospective Registry of Outcomes with Penile Prosthesis for Erectile Restoration (“PROPPER”) study patients consecutively implanted with Conceal™ or spherical reservoirs in submuscular location or in traditional prevesical space

Alternative reservoir site placement (ARP) has become an accepted technique for inflatable penile prosthesis (IPP) patients. There have been no prospective evaluations of this technique, which is currently off-label. The authors performed a prospective, multicenter, multinational, and internal review board (IRB)-approved study to evaluate the effectiveness and safety of ARP

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Impact of synchronous metastasis distribution on cancer-specific survival in renal cell carcinoma after radical nephrectomy with tumor thrombectomy

Metastatic renal cell carcinoma (RCC) can be clinically diverse in terms of the pattern of metastatic disease and response to treatment. We studied the impact of metastasis and location on cancer-specific survival (CSS).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prosbiotate: A multicentric, prospective analysis of infectious complications after prostate biopsy

The side effects of PBs have played a role in the controversy over screening for prostate cancer. We aimed to measure the precise incidence of post-PB infections and to show their risk factors.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Novel Mathematical Model to Predict Severity of Postoperative Functional Reduction before Partial Nephrectomy: The Importance of Calculating Resected and Ischemized Volume (RAIV)

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Epithelial to Mesenchymal Transition in Penile Squamous Cell Carcinoma

The epithelial to mesenchymal transition (EMT) is a phenomenon observed in epithelial tumors that involves loss of intercellular adhesion, mesenchymal phenotype acquisition and enhanced migratory potential. Whereas the EMT process has been extensively linked to the metastatic progression of the squamous cell carcinoma (SCC), studies on the role of EMT in SCC containing high-risk human papillomaviruses are scarce. Moreover, EMT involvement in human penile squamous cell carcinoma (PSCC), that can arise either through transforming HPV infections or independent to HPV, has not been investigated.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Antegrade venography identifies parallel venous duplications in the majority of adolescent patients with a varicocele

To assess the prevalence of internal spermatic venous malformations in adolescent patients with varicocele using intra-operative antegrade venography.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

When the National Kidney Foundation released clinical guidelines in 2002, CKD was defined and staged “independent of underlying cause.”1 During the last decade the impact of CKD on morbidity and mortality has become well documented. The significance of the duration and etiologies of CKD (intrinsic damage to the renal parenchyma as opposed to volume loss) have also become better recognized (reference 15 in article). The authors assert that patients with CKD after surgery (CKD-S) are at a lower risk for nonrenal cancer related mortality than those with CKD from medical diseases (CKD-M).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Obesity and Genitourinary Cancer Risks

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Tissue Engineering of the Bladder—When Will We Get There?

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Renal Surgery and its Impact on Chronic Kidney Disease: A Continuing Evolution in Decision Making

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Home Study Course 2014 Volume 191/192

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Determination of Optimal Drug Dose and Light Dose Index to Achieve Minimally Invasive Focal Ablation of Localized Prostate Cancer Using WST11-Vascular Targeted Photodynamic (VTP) Therapy

C. M. Moore, A. R. Azzouzi, E. Barret, A. Villers, G. Muir, N. Barber, J. Trachtenberg, N. Arumainayagam, B. Gaillac, C. Allen, A. Schertz and M. Emberton

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Vitamin D Deficiency Predicts Prostate Biopsy Outcomes

A. B. Murphy, Y. Nyame, I. K. Martin, W. J. Catalona, C. M. Hollowell, R. B. Nadler, J. M. Kozlowski, K. T. Perry, A. Kajdacsy-Balla and R. Kittles

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Overdiagnosis and Overtreatment of Prostate Cancer

S. Loeb, M. A. Bjurlin, J. Nicholson, T. L. Tammela, D. F. Penson, H. B. Carter, P. Carroll and R. Etzioni

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: A 17-Gene Assay to Predict Prostate Cancer Aggressiveness in the Context of Gleason Grade Heterogeneity, Tumor Multifocality, and Biopsy Undersampling

E. A. Klein, M. R. Cooperberg, C. Magi-Galluzzi, J. P. Simko, S. M. Falzarano, T. Maddala, J. M. Chan, J. Li, J. E. Cowan, A. C. Tsiatis, D. B. Cherbavaz, R. J. Pelham, I. Tenggara-Hunter, F. L. Baehner, D. Knezevic, P. G. Febbo, S. Shak, M. W. Kattan, M. Lee and P. R. Carroll

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Experiences and Treatment Patterns of Hypogonadal Men in a U.S. Health System

E. F. Shortridge, P. Polzer, P. Donga, C. M. Blanchette, F. Fang, C. Burudpakdee and B. Carswell

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Association of Free Testosterone Levels in Men and Lifestyle Factors and Chronic Disease Status: A North Texas Healthy Heart Study

R. Cardarelli, M. Singh, J. Meyer, E. Balyakina, O. Perez and M. King

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Population-Based Patterns of Prescription Androgen Use, 1976-2008

S. A. Hall, G. Ranganathan, L. J. Tinsley, J. L. Lund, V. Kupelian, G. A. Wittert, P. W. Kantoff, A. Morales and A. B. Araujo

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men

W. D. Finkle, S. Greenland, G. K. Ridgeway, J. L. Adams, M. A. Frasco, M. B. Cook, J. F. Fraumeni, Jr. and R. N. Hoover

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Creation of a Continent Urinary Channel in Adults with Neurogenic Bladder: Long-Term Results with the Monti and Casale (Spiral Monti) Procedures

D. Hadley, K. Anderson, C. R. Knopick, K. Shah and B. J. Flynn

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Intermediate Outcomes after Female Urethral Reconstruction: Graft vs Flap

C. Kowalik, J. T. Stoffel, L. Zinman, A. J. Vanni and J. C. Buckley

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Independently Interpreted Retrograde Urethrography Does Not Accurately Diagnose and Stage Anterior Urethral Stricture: The Importance of Urologist-Performed Urethrography

P. Bach and K. Rourke

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparison of Clinical Outcomes between “Ideal” and “Nonideal” Transobturator Male Sling Patients for Treatment of Postprostatectomy Incontinence

R. M. Sturm, M. L. Guralnick, A. R. Stone, G. T. Bales, P. P. Dangle and R. C. O’Connor

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: TAp73 is Required for Spermatogenesis and the Maintenance of Male Fertility

S. Inoue, R. Tomasini, A. Rufini, A. J. Elia, M. Agostini, I. Amelio, D. Cescon, D. Dinsdale, L. Zhou, I. S. Harris, S. Lac, J. Silvester, W. Y. Li, M. Sasaki, J. Haight, A. Brüstle, A. Wakeham, C. McKerlie, A. Jurisicova, G. Melino and T. W. Mak

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Deletion of MgcRacGAP in the Male Germ Cells Impairs Spermatogenesis and Causes Male Sterility in the Mouse

P. Lorès, N. Vernet, T. Kurosaki, T. Van de Putte, D. Huylebroeck, M. Hikida, G. Gacon and A. Touré

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: A Heterozygous Mutation of GALNTL5 Affects Male Infertility with Impairment of Sperm Motility

N. Takasaki, K. Tachibana, S. Ogasawara, H. Matsuzaki, J. Hagiuda, H. Ishikawa, K. Mochida, K. Inoue, N. Ogonuki, A. Ogura, T. Noce, C. Ito, K. Toshimori and H. Narimatsu

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: TRAIL-Coated Leukocytes that Kill Cancer Cells in the Circulation

M. J. Mitchell, E. Wayne, K. Rana, C. B. Schaffer and M. R. King

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Urothelial Carcinoma of the Upper Urinary Tract

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Renal Oncocytosis

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Pediatric Urology

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Adult Urology

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Risk of Urinary Tract Infection after Flexible Cystoscopy in Bladder Tumor Patients who did not receive Prophylactic Antibiotics

To determine the frequency of febrile urinary tract infection (UTI) after outpatient flexible cystoscopy in antibiotic-naïve bladder tumor patients.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Desert Hedgehog (DHH) is an independent prognosticator of oncologic outcome in clear cell renal cell carcinoma

Aberrant hedgehog (HH) signaling has been proven important in the pathogenesis of several solid cancers. Limited in vitro analyses suggest an oncogenic role for HH in RCC. In this explorative study we sought to validate aberrant HH expression in patients with RCC.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Primary and reoperative hypospadias repair in adults: are results different than in children?

There is widespread belief that hypospadias surgery in adults has greater urethroplasty complication rates than similar repairs in children. We compare outcomes for primary and reoperative hypospadias repair in adults versus children.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Sunitinib, pazopanib or sorafenib for the treatment of patients with late-relapsing (>5 years) metastatic renal cell carcinoma

Late recurrence of renal cell carcinoma (RCC) is not a rare event. The aim of this retrospective study was to investigate the clinico-pathological features and the outcome of patients (pts) treated with sorafenib, sunitinib and pazopanib for late-relapsing renal cell carcinoma (LR-RCC).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Circulating serum microRNA (miR-367-3p, miR-371a-3p, miR-372-3p, miR-373-3p) as biomarkers for patients with testicular germ cell cancers

Classic serum tumor markers (HCG, AFP, LDH) play an important role in management of testicular germ cell tumor (TGCT). As only 60% of all TGCT patients have elevations of these, there is need for new biomarkers which offer greater sensitivity/specificity.MicroRNAs are deregulated in cancer and could serve as non-invasive serum biomarkers; the present study explores the role of serum microRNAs as novel biomarkers in patients with TGCT.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A combination of hemostatic agents may safely replace deep medullary suture during laparoscopic partial nephrectomy in a pig model

To assess whether a Tisseel® plus FloSeal® combination may safely replace the conventional deep medullary suture without compromising outcomes.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Bladder Instillation of Liposome Encapsulated OnabotulinumtoxinA Improves Overactive Bladder Symptoms- A Prospective Multi-center Double Blind Randomized Trial

Cystoscopic intradetrusor injection of botulinum toxin has helped patients with refractory overactive bladder (OAB), but with increased risks of urinary tract infection and urinary retention. We assessed whether catheter instillation of onabotulinumtoxinA 200 U formulated with liposomes (lipo-BoNT) is safe and effective for the treatment of OAB.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Lower Urinary Tract Pain And Anterior Urethral Stricture Disease: Prevalence And Effects Of Urethral Reconstruction

Anterior urethral stricture disease most commonly presents with manifestations of urinary obstruction; lower urinary tract pain (LUTP) is not commonly reported as a presenting symptom. We set out to prospectively characterize LUTP in association with urethral stricture disease and assess the effects of urethroplasty on this pain.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: An alpha1-Adrenoceptor Blocker Terazosin Improves Urine Storage Function in the Spinal Cord in Spinal Cord Injured Rats

M. Miyazato, T. Oshiro, M. B. Chancellor, W. C. de Groat, N. Yoshimura and S. Saito

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Neural Pathways Involved in Sacral Neuromodulation of Reflex Bladder Activity in Cats

F. Zhang, S. Zhao, B. Shen, J. Wang, D. E. Nelson, J. R. Roppolo, W. C. de Groat and C. Tai

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Nerve Growth Factor (NGF): A Potential Urinary Biomarker for Overactive Bladder Syndrome (OAB)?

J. H. Seth, A. Sahai, M. S. Khan, F. van der Aa, D. de Ridder, J. N. Panicker, P. Dasgupta and C. J. Fowler

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Are the Measurements of Water-Filled and Air-Charged Catheters the Same in Urodynamics?

G. A. Digesu, A. Derpapas, P. Robshaw, G. Vijaya, C. Hendricken and V. Khullar

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: An Evidence-Based Approach to Urodynamic Testing

L. Brubaker

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Rs189037, a Functional Variant in ATM Gene Promoter, is Associated with Idiopathic Nonobstructive Azoospermia

Z. Li, J. Yu, T. Zhang, H. Li and Y. Ni

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: p,p′-DDE Activates CatSper and Compromises Human Sperm Function at Environmentally Relevant Concentrations

R. S. Tavares, S. Mansell, C. L. Barratt, S. M. Wilson, S. J. Publicover and J. Ramalho-Santos

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Cigarette Smoking is Associated with Abnormal Histone-to-Protamine Transition in Human Sperm

B. Yu, Y. Qi, D. Liu, X. Gao, H. Chen, C. Bai and Z. Huang

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Danish Sperm Donors across Three Decades: Motivations and Attitudes

B. Bay, P. B. Larsen, U. S. Kesmodel and H. J. Ingerslev

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Germline Stem Cells: Toward the Regeneration of Spermatogenesis

H. Valli, B. T. Phillips, G. Shetty, J. A. Byrne, A. T. Clark, M. L. Meistrich and K. E. Orwig

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Tivozanib versus Sorafenib as Initial Targeted Therapy for Patients with Metastatic Renal Cell Carcinoma: Results from a Phase III Trial

R. J. Motzer, D. Nosov, T. Eisen, I. Bondarenko, V. Lesovoy, O. Lipatov, P. Tomczak, O. Lyulko, A. Alyasova, M. Harza, M. Kogan, B. Y. Alekseev, C. N. Sternberg, C. Szczylik, D. Cella, C. Ivanescu, A. Krivoshik, A. Strahs, B. Esteves, A. Berkenblit and T. E. Hutson

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Tumor Growth Rate Provides Useful Information to Evaluate Sorafenib and Everolimus Treatment in Metastatic Renal Cell Carcinoma Patients: An Integrated Analysis of the TARGET and RECORD Phase 3 Trial Data

C. Ferté, S. Koscielny, L. Albiges, L. Rocher, J. C. Soria, R. Iacovelli, Y. Loriot, K. Fizazi and B. Escudier

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: EAU Guidelines on the Treatment and Follow-up of Non-Neurogenic Male Lower Urinary Tract Symptoms Including Benign Prostatic Obstruction

M. Oelke, A. Bachmann, A. Descazeaud, M. Emberton, S. Gravas, M. C. Michel, J. N’dow, J. Nordling and J. J. de la Rosette; European Association of Urology

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparison of 7 α-Adrenoreceptor Antagonists in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia: A Short-Term Crossover Study

T. Araki, K. Monden and M. Araki

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Association of Physician Specialty and Medical Therapy for Benign Prostatic Hyperplasia

L. C. Han, S. P. Kim, C. P. Gross, J. S. Ross, H. K. Van Houten, M. C. Smaldone, A. E. Krambeck and N. D. Shah

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Brain Responses to Bladder Filling in Older Women without Urgency Incontinence

S. D. Tadic, C. Tannenbaum, N. M. Resnick and D. Griffiths

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Relationship between Cerebral White Matter Hyperintensities and Lower Urinary Tract Function in a Population Based, Geriatric Cohort

C. Wehrberger, S. Jungwirth, P. Fischer, K. H. Tragl, W. Krampla, W. Marlies and S. Madersbacher

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Randomised, Multicentre, Placebo-Controlled, Double-Blind Crossover Study Investigating the Effect of Solifenacin and Oxybutynin in Elderly People with Mild Cognitive Impairment: The SENIOR Study

A. Wagg, M. Dale, R. Tretter, B. Stow and G. Compion

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Serum Total Testosterone Level and Identification of Late-Onset Hypogonadism: A Community-Based Study

S. Kang, H. J. Park and N. C. Park

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Relationship of Testis Size and LH Levels with Incidence of Major Adverse Cardiovascular Events in Older Men with Sexual Dysfunction

G. Rastrelli, G. Corona, F. Lotti, V. Boddi, E. Mannucci and M. Maggi

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Do Antibiotic Prophylaxis and/or Circumcision Change Periurethral Uropathogen Colonization and Urinary Tract Infection Rates in Boys with VUR?

A. Gücük, B. Burgu, İ Gökçe, M. Mermerkaya and T. Soygür

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Reduced Bacterial Colonisation of the Glans Penis after Male Circumcision in Children—A Prospective Study

H. N. Ladenhauf, M. A. Ardelean, C. Schimke, F. Yankovic and G. Schimpl

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Anatomy of the Dorsal Nerve of the Penis, Clinical Implications

Z. Kozacioglu, A. Kiray, I. Ergur, G. Zeybek, T. Degirmenci and B. Gunlusoy

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Impact of Chemotherapy and Radiotherapy for Testicular Germ Cell Tumors on Spermatogenesis and Sperm DNA: A Multicenter Prospective Study from the CECOS Network

L. Bujan, M. Walschaerts, N. Moinard, S. Hennebicq, J. Saias, F. Brugnon, J. Auger, I. Berthaut, E. Szerman, M. Daudin and N. Rives

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Solid Tumors after Chemotherapy or Surgery for Testicular Nonseminoma: A Population-Based Study

C. Fung, S. D. Fossa, M. T. Milano, J. Oldenburg and L. B. Travis

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: National Trends in Patient Safety for Four Common Conditions, 2005-2011

Y. Wang, N. Eldridge, M. L. Metersky, N. R. Verzier, T. P. Meehan, M. M. Pandolfi, J. M. Foody, S. Y. Ho, D. Galusha, R. E. Kliman, N. Sonnenfeld, H. M. Krumholz and J. Battles

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The authors present early data regarding implementation of a surgical safety checklist by hospitals in Ontario. They compared 3-month complication rates before and after the use of checklists and found no reduction in either operative mortality or complications. What is not reported is whether implementation of the checklist improved intraoperative communication or changed the culture within the operating room. Long-term studies are needed to fully evaluate the effect of checklists on outcomes.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Introduction of Surgical Safety Checklists in Ontario, Canada

D. R. Urbach, A. Govindarajan, R. Saskin, A. S. Wilton and N. N. Baxter

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: A Prospective Study Examining the Association between Preoperative Frailty and Postoperative Complications in Patients Undergoing Minimally Invasive Surgery

L. M. Revenig, D. J. Canter, V. A. Master, S. K. Maithel, D. A. Kooby, J. G. Pattaras, C. Tai and K. Ogan

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Initial Experiences of a Novel Self-Retaining Intracorporeal Retractor Device for Urologic Laparoendoscopic Single-Site Surgery

S. H. Choo, W. Jung, U. Jeong, B. C. Jeong and D. H. Han

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: In Vitro Anti-Inflammatory Activity of Selected Oxalate-Degrading Probiotic Bacteria: Potential Applications in the Prevention and Treatment of Hyperoxaluria

S. Giardina, C. Scilironi, A. Michelotti, A. Samuele, F. Borella, M. Daglia and F. Marzatico

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparison between Spinal and General Anesthesia in Percutaneous Nephrolithotomy

G. Movasseghi, V. Hassani, M. R. Mohaghegh, R. Safaeian, S. Safari, M. M. Zamani and R. Nabizadeh

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Differences in Ureteroscopic Stone Treatment and Outcomes for Distal, Mid-, Proximal, or Multiple Ureteral Locations: The Clinical Research Office of the Endourological Society Ureteroscopy Global Study

E. Perez Castro, P. J. Osther, V. Jinga, H. Razvi, K. G. Stravodimos, K. Parikh, A. R. Kural and J. J. de la Rosette; CROES Ureteroscopy Global Study Group

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Improving the Lens Design and Performance of a Contemporary Electromagnetic Shock Wave Lithotripter

A. Neisius, N. B. Smith, G. Sankin, N. J. Kuntz, J. F. Madden, D. E. Fovargue, S. Mitran, M. E. Lipkin, W. N. Simmons, G. M. Preminger and P. Zhong

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Robotic-Assisted Radical Cystectomy with Extracorporeal Urinary Diversion for Urothelial Carcinoma of the Bladder: Analysis of Complications and Oncologic Outcomes in 175 Patients with a Median Follow-up of 3 Years

E. Xylinas, D. A. Green, B. Otto, A. Jamzadeh, L. Kluth, R. K. Lee, B. D. Robinson, S. F. Shariat and D. S. Scherr

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Accuracy of Multiparametric Magnetic Resonance Imaging in Confirming Eligibility for Active Surveillance for Men with Prostate Cancer

L. Stamatakis, M. M. Siddiqui, J. W. Nix, J. Logan, S. Rais-Bahrami, A. Walton-Diaz, A. N. Hoang, S. Vourganti, H. Truong, B. Shuch, H. L. Parnes, B. Turkbey, P. L. Choyke, B. J. Wood, R. M. Simon and P. A. Pinto

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Antimicrobial Prophylaxis for Children with Vesicoureteral Reflux

A. Hoberman, S. P. Greenfield, T. K. Mattoo, R. Keren, R. Mathews, H. G. Pohl, B. P. Kropp, S. J. Skoog, C. P. Nelson, M. Moxey-Mims, R. W. Chesney and M. A. Carpenter; RIVUR Trial Investigators

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Cranberries for Preventing Urinary Tract Infections

R. G. Jepson, G. Williams and J. C. Craig

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Red Blood Cell Transfusions and the Risk of Allosensitization in Patients Awaiting Primary Kidney Transplantation

M. S. Leffell, D. Kim, R. M. Vega, A. A. Zachary, J. Petersen, J. M. Hart, J. Rossert and B. D. Bradbury

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Aspirin in Patients Undergoing Noncardiac Surgery

P. J. Devereaux, M. Mrkobrada, D. I. Sessler, K. Leslie, P. Alonso-Coello, A. Kurz, J. C. Villar, A. Sigamani, B. M. Biccard, C. S. Meyhoff, J. L. Parlow, G. Guyatt, A. Robinson, A. X. Garg, R. N. Rodseth, F. Botto, G. Lurati Buse, D. Xavier, M. T. V. Chan, M. Tiboni, D. Cook, P. A. Kumar, P. Forget, G. Malaga, E. Fleischmann, M. Amir, J. Eikelboom, R. Mizera, D. Torres, C. Y. Wang, T. VanHelder, P. Paniagua, O. Berwanger, S. Srinathan, M. Graham, L. Pasin, Y. Le Manach, P. Gao, J. Pogue, R. Whitlock, A.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Ureteral Reimplantation in Adults: Open Versus Robotic

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

Tufik et al are correct in that testosterone replacement therapy can worsen sleep apnea in some men. We have one of the largest populations of adolescents with Klinefelter syndrome followed longitudinally for a decade, and we have never observed an adolescent complain of problems with sleep or morning fatigue indicating sleep apnea. Thus, we are unsure whether the concerns raised by Tufik et al apply to adolescents. The BMIs of adolescents treated in our practice are actually lower than age matched American controls.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

The comments of Das et al regarding the contribution of the fibers from the superior hypogastric and inferior mesenteric plexus to renal innervation are largely consistent with those reported in the literature and appear generally correct. However, our article focused entirely on evaluation of the autonomic nervous system from the main renal vessels deep into the renal cortex. We did not evaluate the more proximal nerve distribution on the main renal artery because this anatomy is well described in the literature.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Intrarenal and Extrarenal Autonomic Nervous System Redefined

We read this article with great interest, and we compliment the authors and editor for highlighting this rare topic. As anatomists, we wish to express our scientific views on the study.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Safety and Efficacy of Testosterone Replacement Therapy in Adolescents with Klinefelter Syndrome

The authors observed for the first time the long-term effects of testosterone replacement therapy (TRT) in adolescents with Klinefelter syndrome (KS). Although this issue is rarely examined, we would like to emphasize the importance of their approach to better understand this relatively frequent genetic disorder, and we would like to propose a deeper analysis of the effects of its treatment, especially through an overview of sleep in these patients.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prevalence and Management of Lower Urinary Tract Symptoms in Methamphetamine Abusers: An Under-Recognized Clinical Identity

We read this article with great interest. The authors evaluated the prevalence and management of lower urinary tract symptoms (LUTS) in methamphetamine (METH) abusers. They conclude that LUTS are highly prevalent in METH abusers and pathological dopaminergic mechanisms may have a fundamental role in METH associated LUTS. There are several concerns about these conclusions that require further discussion.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Tumor Target Volume for Focal Therapy of Prostate Cancer—Does Multiparametric Magnetic Resonance Imaging Allow for a Reliable Estimation?

Cornud et al address the value of preoperative multiparametric magnetic resonance imaging (mpMRI) for determining a focal therapeutic treatment plan. By taking whole mount radical prostatectomy specimens as the reference standard, the authors calculated the accuracy of single mpMRI sequences alone or in combination to determine which predicted better actual tumor volume. They found that the use of “target volume,” defined using the largest tumor area visible on any mpMRI sequence, reduced volume underestimation to a minimum of 17% but in turn led to an overestimation of actual tumor volume in 44% of cases.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Investigative Urology

Increased prostatic smooth muscle tone may contribute to the dynamic part of bladder outflow obstruction and associated lower urinary tract symptoms. Myogenic contractions may also contribute. Spontaneous phasic contractions of the guinea pig prostate stroma appear to primarily rely on spontaneous Ca2+ release from the endoplasmic/sarcoplasmic reticulum and subsequent opening of Ca2+ activated chloride channels. Shigemasa et al (page XXXX) from Japan investigated the involvement of voltage dependent mechanisms regulating this slow wave frequency.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Robotic Intracorporeal Orthotopic Neobladder During Radical Cystectomy in 132 Patients

To present a 2-institution experience with completely intracorporeal robotic orthotopic ileal neobladder following radical cystectomy in 132 patients.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Emergency Department Care Patterns in Spina Bifida Patients: a Case-Control Study

Spina bifida (SB) patients are typically closely followed as outpatients by multidisciplinary teams. However, emergency care among SB patients is not well-defined. We sought to describe patterns of SB emergency care patterns compared to non-SB controls.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Improved split renal function after percutaneous nephrostomy in young adults with severe hydronephrosis due to ureteropelvic junction obstruction

To evaluate percutaneous nephrostomy (PCN) for adult kidneys with severe hydronephrosis due to ureteropelvic junction obstruction (UPJO) and split renal function < 10%.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Prospective, Multi-Institutional Study of Flexible Ureteroscopy for Proximal Ureteral Stones < 2 cm

Flexible ureteroscopy (URS) is rapidly becoming a first-line therapy for many with renal and ureteral stones. However, the present understanding of treatment outcomes for patients with isolated proximal ureteral stones is limited. Therefore, we performed a prospective, multi-institutional study of ureteroscopic management of proximal ureteral stones < 2 cm in order to better define clinical outcomes associated with this approach.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Expression of The Tumor Suppressive microRNA-23b/27b Cluster is A Good Prognostic Marker in Clear Cell Renal Cell Carcinoma

Abnormal expression of the microRNA-23b/27b (miR-23b/27b) cluster was observed in our previous study of miRNA expression signatures. However, the relationship between aberrant expression of miRNAs and ccRCC is not well established. The aim of this study was to investigate the functional significance of the miR-23b/27b cluster in ccRCC cells and to evaluate these miRNAs as biomarkers to predict the risk of ccRCC.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Artificial Urinary Sphincter Placement and Survival in Compromised Urethras – A Comparison of Virgin, Radiated, and Re-Operative Cases

Although long-term outcomes after initial placement of artificial urinary sphincters (AUS) are established, limited data comparing sphincter survival in patients with compromised urethras (prior radiation, AUS placement, or urethroplasty) exists. We evaluated AUS failure in patients with compromised and non-compromised urethras.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Microcirculatory Effects of Selective Endothelin-A Receptor Antagonism in Testicular Torsion

Testicular torsion without timely intervention causes incurable damage to the testis. In the present study, the causative role of a microcirculatory injury in torsion-induced testicular damage was examined with particular regard to in endothelin-A (ET-A) receptor activation.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The authors evaluated 735 men treated with RP for PCa, measuring PPI using different definitions. The most relevant conclusion is that preoperative sexual dysfunction and urinary incontinence were the strongest predictors of persistent PPI.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Risk of Developing Diabetes after Shock Wave Lithotripsy

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The authors are to be commended for their in-depth and detailed initial analysis and followup evaluation of this complex subgroup of patients with bladder exstrophy. This is indeed a challenging group, ie patients with bladder exstrophy undergoing combined bladder and epispadias repair at a mean age of 8.9 years (range 5 to 18).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The authors present a provocative analysis of a large database to help increase our current knowledge regarding 2 surgical modalities for addressing pediatric renal tumors. Reassuringly, despite the infrequent use of nephron sparing surgery and admitted limitations imposed by their research strategy, overall survival did not appear to be affected against the gold standard, radical nephrectomy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The authors present the largest, most generalizable study demonstrating a delay in referral for and evaluation of hematuria in women compared with men. They imply that this delay contributes to the higher stage of bladder cancer at diagnosis in women and to their worse outcomes. However, using an overlapping data source Scosyrev et al concluded that stage and histology at presentation explained only about 30% of the higher bladder cancer mortality experienced by (particularly white) females and other factors must contribute far more to this difference.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Extended Antimicrobial Usage Among Patients Undergoing Percutaneous Nephrolithotomy and Associated Antibiotic Related Complications

Despite global concerns for antibiotic related complications, the duration of antibiotic therapy at time of percutaneous nephrolithotomy (PCNL) varies based upon individual physician practice. Herein, we evaluate perioperative antibiotic related complications among patients receiving extended antimicrobial therapy at PCNL.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Histopathological characteristics of buccal mucosa transplants in humans after engraftment to the urethra: A prospective study

The histopathological changes of buccal mucosa transplants after engraftment to the urethra and urine-exposure remain nebulous. To investigate the histopathological changes of buccal mucosa transplants integrated into the urethra in humans.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Phase II Trial of Intravesical Nanoparticle Albumin-Bound () Paclitaxel for the Treatment of Non-Muscle Invasive Urothelial Carcinoma of the Bladder after BCG Treatment Failure

Response rates to current second-line intravesical therapies for recurrent non-muscle-invasive bladder cancer (NMIBC) range between 10 and 30%. Nanoparticle albumin-bound (nab-)paclitaxel has increased solubility and lower toxicity compared to other taxanes. Results of the phase I intravesical trial of this compound demonstrated minimal toxicity during dose escalation. We now report the results of a Phase II trial to assess efficacy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

TURBT Can Cause Seeding of Cancer Cells into the Bloodstream

TURBT is the initial diagnostic procedure in bladder cancer (BC). Hypothetically, tumor resection could induce seeding of cancer cells into the circulation and subsequent metastatic disease. The objective of this study was to ascertain whether TURBT induces measurable seeding of cancer cells into the vascular system.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Intravesical Application of Rebamipide Promotes Urothelial Healing in a Rat Cystitis Model

Rebamipide is used as a topical therapeutic agent for various organs. We examined the healing effects of intravesical application of rebamipide on a damaged urothelium using a chemically induced cystitis rat model.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Effects of reconstructive surgery on bladder function in patients with anorectal malformations

Bladder dysfunction is common in patients with anorectal malformations, and can be congenital or acquired as a consequence of surgery. Aim of this study was to investigate effects of the surgical correction of anorectal malformations on bladder function.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Novel Urine Cytology Stain for the Detection and Monitoring of Bladder Cancer

CellDetect® is a unique platform technology which enables color discrimination between malignant (red) and benign (green) cells based on specific metabolic alterations exclusive to the former. Pre-clinical studies and clinical trials have demonstrated applicability of CellDetect® in a plethora of cell culture lines and in various cancers. The purpose of the current study was to explore the performance characteristics of CellDetect® in bladder cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Thiazide Diuretic Prophylaxis for Kidney Stones and the Risk of Diabetes Mellitus

Thiazide diuretics used to treat hypertension (HTN) associate with a modest risk of diabetes mellitus (DM). It is unknown if there is a similar risk with kidney stone prevention.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Meatal stenosis in boys following circumcision for Lichen Sclerosus et Atrophicus (Balanitis Xerotica Obliterans)

Lichen sclerosus et atrophicus (LS of the male genitalia) is also called Balanitis Xerotica Obliterans (BXO). Recent studies report that 7 - 19% of boys circumcised for LS require late surgery for meatal stenosis. We review management and outcomes of boys circumcised for LS.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Evaluation of Acute Post-SWL Renal Changes by dynamic MRI: A Prospective Clinical Study

To study the acute renal morphologic and hemodynamic changes after SWL of renal stones.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Ultrasound Guided Ureteroscopy for the Definitive Management of Ureteral Stones: A Randomized Controlled Trial

Ureteroscopy is central to the surgical management of ureteral stones. Conventionally, fluoroscopy is utilized for intraoperative guidance, although there is growing effort to reduce exposure of patients and staff to ionizing radiation. We developed a radiation -free approach to ureteroscopy using ultrasound guidance for management of ureteral stones, and present the first randomized trial to study its safety and efficacy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prognostic value of promoter methylation in prostate cancer

Prostate cancer (PCa) patients with biochemical recurrence (BCR) following curative therapy are at higher risk of distant metastasis and cancer-specific death. Assessment of aberrant DNA methylation in urine might complement currently used clinical prognostic factors and serve as non-invasive tool for early prediction of BCR after radical prostatectomy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Expression and Role of Leptin under Hypoxic Conditions in Human Testis:Organotypic in-Vitro Culture Experiment and Clinical Study on Patients with Varicocele

To investigate the expression and the exact role of leptin under hypoxic conditions in human testis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Five Year-median Follow-up

Although there is no evidence that testosterone (T) therapy increases risk of prostate cancer (PCa), there is a paucity of long-term data.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

CTR2 identifies a population of cancer cells with stem-like features in patients with clear cell-renal cell carcinoma

The aim of the present study was to identify and characterize in tissue samples of clear cell-renal cell carcinoma (ccRCC) a population of CD133+/CD24+ cancer cells (RCC-derived cells–RDCs) and to study the differences with their non-neoplastic counterpart, tubular Adult Renal Progenitor Cells (ARPCs).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Unintented Negative Consequences of Primary Endoscopic Realignment for Men with Pelvic Fracture Urethral Injuries

We evaluated the clinical course of PFUI patients referred to our institution in an attempt to elucidate the differences between initial management strategies.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Bladder biopsy of normal-appearing mucosa is not helpful in patients with unexplained positive cytology after non-muscle invasive bladder cancer

Malignant voided cytology with normal endoscopic evaluation represents a diagnostic and therapeutic challenge for many patients with a history of non-muscle-invasive bladder cancer (NMIBC). Bladder biopsy is often advised but its efficacy is unclear. We seek to evaluate the usefulness of bladder biopsy for patients with unexplained positive cytology and to describe patterns of recurrence for this unique subset of patients.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Grade Heterogeneity in Small Renal Masses: Potential Implications for Renal Mass Biopsy

Understanding the degree of phenotypic heterogeneity within a small renal mass (SRM) may have implications for interpreting renal mass biopsy (RMB) data. In this study we sought to quantify the nuclear grade heterogeneity within SRMs.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Completely Intracorporeal Robotic Renal Autotransplantation

To describe the first report of a technique for performing completely intracorporeal renal autotransplantation with both the donor nephrectomy and transplantation performed minimally-invasively without ever extracting the kidney.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Evaluation and Medical Management of Kidney Stones in Children

To appraise the current literature on the diagnostic evaluation and dietary and pharmacologic management of children with nephrolithiasis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Optimizing Outcomes of Urethroplasty

“Success depends upon previous preparation, and without such preparation there is sure to be failure.”–Confucius

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Legacy of Ernest A. Codman in the 21st Century

More than a century ago Ernest Codman laid forth his concept of the “End Results Idea,” which was revolutionary at the time, with “the common sense notion that every hospital should follow every patient it treats, long enough to determine whether or not the treatment has been successful, and then to inquire, ‘If not, why not?’ with a view to preventing similar failures in the future.”1 Today assessment, monitoring and reporting of quality are becoming increasingly ubiquitous in our practice and regulatory environment.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

To V(CUG) or Not to V(CUG) in Infants with Prenatal Hydronephrosis?

This is a critical question that may throw even the noblest of pediatric urologists into a quandary. Our desire to help our patients simply will not allow us to stand idle and watch them “suffer the slings and arrows of outrageous fortune” that vesicoureteral reflux (VUR) can yield.1 “To take arms against a sea of troubles” is our alternative.1 The core of this modern-day conflict is whether diagnosing VUR in asymptomatic patients has long-term health benefits. Currently it is not clear which patients diagnosed prenatally will go on to have clinically significant VUR.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Management of germ cell tumors with somatic-type malignancy: pathologic features, prognostic factors, and survival outcomes

Germ cell tumors (GCT) with somatic-type malignancy (SM) are rare occurring in approximately 2.7-8.6% of GCT cases. Prognostic factors and optimal management remain poorly-defined.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prompt Management of Anastomotic Leak or Acute Obstruction after Minimally Invasive Pyeloplasty with Percutaneous Nephrostomy Preserves Outcomes

Urine leak or obstruction in the early postoperative period are worrisome complications of pyeloplasty. Suboptimal management may risk long term success. We evaluated the use of percutaneous nephrostomy (PCN) to manage complications of minimally invasive pyeloplasty (MIP).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Home Study Course 2014 Volume 191/192

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

News and Announcements

President – Dr. William W. Bohnert, 3500 E. Lincoln Drive, Lot #33, Phoenix, Arizona 85018

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Impact of Adjuvant Radiation Therapy on Urinary Continence Recovery after Radical Prostatectomy

N. Suardi, A. Gallina, G. Lista, G. Gandaglia, F. Abdollah, U. Capitanio, P. Dell'Oglio, A. Nini, A. Salonia, F. Montorsi and A. Briganti

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Long-Term Follow-up after Regenerative Therapy of the Urethral Sphincter for Female Stress Urinary Incontinence

J.-N. Cornu, D. Lizée, C. Pinset and F. Haab

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Current Status of Bulking Agents for Urinary Incontinence

L. S. MacLachlan and E. S. Rovner

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Mirabegron for Male Lower Tract Symptoms

O. Suarez, D. Osborn, M. Kaufman, W. S. Reynolds and R. Dmochowski

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: β-Receptor Agonists for Overactive Bladder—New Frontier or More of the Same?

K. E. Andersson

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Neoadjuvant Androgen Deprivation Therapy Leads to Immediate Impairment of Vitality/Hormonal and Sexual Quality of Life: Results of a Multicenter Prospective Study

H. A. Gay, J. M. Michalski, D. A. Hamstra, J. T. Wei, R. L. Dunn, E. A. Klein, H. M. Sandler, C. Saigal, M. Litwin, D. Kuban, L. Hembroff, P. Chang and M. G. Sanda; PROSTQA Consortium

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: What is the Clinical Significance of FDG Unexpected Uptake in the Prostate in Patients Undergoing PET/CT for Other Malignancies?

P. Bhosale, A. Balachandran, R. Vikram, C. Viswanathan, H. Macapinlac, E. Rohren and R. Prativadi

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Urologists’ Use of Intensity-Modulated Radiation Therapy for Prostate Cancer

J. M. Mitchell

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prostate Biopsy for the Interventional Radiologist

C. W. Hong, H. Amalou, S. Xu, B. Turkbey, P. Yan, J. Kruecker, P. A. Pinto, P. L. Choyke and B. J. Wood

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Penile Plication for Peyronie’s Disease: Our Results with Mean Follow-up of 103 Months on 89 Patients

U. Cantoro, M. Polito, F. Catanzariti, L. Montesi, V. Lacetera and G. Muzzonigro

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Penile Straightening Maneuvers Employed during Penile Prosthesis Surgery: Technical Options and Outcomes

R. L. Segal, M. R. Cabrini, T. J. Bivalacqua and A. L. Burnett

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Asexuality Development among Middle Aged and Older Men

Y. P. Huang, B. Chen, P. Ping, H. X. Wang, K. Hu, H. Yang, T. Zhang, T. Feng, Y. Jin, Y. F. Han, Y. X. Wang and Y. R. Huang

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Effect of Once-Daily Tadalafil on Confidence and Perceived Difficulty in Performing Sexual Intercourse in Men who were Incomplete Responders to As-Needed PDE5 Inhibitor Treatment

A. D. Seftel, R. C. Rosen, R. P. Hayes, S. Althof, E. Goldfisher, W. Shen and A. Sontag

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Duration of Erection: Does it Really Matter? A Randomized, Double-Blind Clinical Trial to Assess the Impact of Vardenafil ODT on Duration of Erection and its Correlation with Patients’ and Partners’ Sexual Quality of Life and Duration of Intercourse: The VADEOPEN Study

A. Martin-Morales, P. Gutiérrez-Hernández, J. Romero-Otero and J. A. Romero-Martín; Vadeopen Study Group

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Erectile Dysfunction, Vascular Risk, and Cognitive Performance in Late Middle Age

C. S. Moore, M. D. Grant, T. A. Zink, M. S. Panizzon, C. E. Franz, M. W. Logue, R. L. Hauger, W. S. Kremen and M. J. Lyons

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prostate Cancer Patients Older than 70 Years Treated by Radical Prostatectomy Have Higher Biochemical Recurrence Rate than their Matched Younger Counterpart

J. Ko, S. M. Falzarano, E. Walker, K. Streator Smith, A. J. Stephenson, E. A. Klein and C. Magi-Galluzzi

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Lower Urinary Tract Symptoms and Falls Risk among Older Women Receiving Home Support: A Prospective Cohort Study

K. F. Hunter, D. Voaklander, Z. Y. Hsu and K. N. Moore

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Overactive Bladder Symptom Severity is Associated with Falls in Community-Dwelling Adults: LOHAS Study

N. Kurita, S. Yamazaki, N. Fukumori, K. Otoshi, K. Otani, M. Sekiguchi, Y. Onishi, M. Takegami, R. Ono, S. Horie, S. Konno, S. Kikuchi and S. Fukuhara

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Mobility Impairment is Associated with Urge but Not Stress Urinary Incontinence in Community-Dwelling Older Women: Results from the Ossébo Study

X. Fritel, L. Lachal, B. Cassou, A. Fauconnier and P. Dargent-Molina

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Internet-Based Treatment of Stress Urinary Incontinence: A Randomised Controlled Study with Focus on Pelvic Floor Muscle Training

M. Sjöström, G. Umefjord, H. Stenlund, P. Carlbring, G. Andersson and E. Samuelsson

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Choriocarcinoma of the Testis

Choriocarcinoma of the testis is a highly malignant germ cell neoplasm that exhibits trophoblastic differentiation.1–4 This tumor differs from most testicular tumors in that it often presents metastatic disease rather than as a palpable testicular mass. It is most commonly detected as a component of a mixed malignant germ cell tumor and observed in about 7% to 8% of testicular tumors. Exceedingly rare in pure form, choriocarcinoma comprises only 0.2% to 0.6% of all testis tumors.1,3,4

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Predictive Value of C-Reactive Protein for Prognosis in Patients with Upper Tract Urothelial Carcinoma Treated with Radical Nephroureterectomy: A Multi-Institutional Study

N. Tanaka, E. Kikuchi, S. Shirotake, K. Kanao, K. Matsumoto, H. Kobayashi, Y. Miyazaki, H. Ide, J. Obata, K. Hoshino, N. Hayakawa, Y. Ito, T. Kosaka, K. Kodaira, M. Oyama, A. Miyajima, T. Momma, K. Nakagawa, M. Ueno and M. Oya

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Defining Early-Onset Kidney Cancer: Implications for Germline and Somatic Mutation Testing and Clinical Management

B. Shuch, S. Vourganti, C. J. Ricketts, L. Middleton, J. Peterson, M. J. Merino, A. R. Metwalli, R. Srinivasan and W. M. Linehan

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Pediatric Urology

An appropriate clinical question to ask ourselves is how often we should obtain followup ultrasound in patients with prenatal hydronephrosis. Akhavan et al (page 919) from Seattle, Washington attempt to answer this question by performing a retrospective analysis of term infants born with hydronephrosis evaluated at their institution from 2006 to 2010.1 Data were analyzed for a 3-year follow- up period with end points being either resolution of the hydronephrosis or surgery (pyeloplasty). As expected, patients with grades 3 and 4 hydronephrosis had a greater chance of undergoing surgery and, therefore, by definition ultrasound was more efficient at identifying those with a true clinical urological issue.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Adult Urology

As more complications develop with mesh, patients seem reluctant to use mid urethral slings that incorporate mesh therapies. Alternatively, the morbidity of pubofascial retropubic slings is not inconsequential and, therefore, new therapies for stress urinary incontinence are welcomed. Sokol et al (page 843) from Nashville, Tennessee compared Bulkamid (group 1, 229 women) and Contigen® (group 2, 116 women) for stress urinary incontinence in a prospective, randomized, noninferiority study comparing two bulking agents.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Investigative Urology

To advance clinical phenotyping and treatment efforts for interstitial cystitis/painful bladder syndrome (IC/PBS), Kilpatrick et al (page 947) tested the hypothesis that female patients with IC/PBS would show altered oscillation frequency and functional connectivity in visceromotor and sensorimotor regions compared to healthy controls.1 The study was part of MAPP (Multidisciplinary Approach to the Study of Chronic Pelvic Pain). The group examined oscillation dynamics of intrinsic brain activity in a large sample of well phenotyped female patients with IC/PBS and healthy female controls collected during resting functional magnetic resonance imaging.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

DNA Copy-Number Variations in 46,XY Disorders of Sex Development

Less than 50% of 46,XY disorders of sex development (DSD) cases are genetically defined after karyotyping and/or sequencing of known DSD causal genes. As copy-number variations (CNVs) are often missed by karyotyping and sequencing, the goal of this study was to assess cases of unexplained 46,XY DSD by array-comparative genomic hybridization (aCGH) for possible disease-causing genomic variants.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Metastatic “Burned-Out” Germ Cell Tumor of the Testis

A 20-year-old man presented with a 3-week history of right upper quadrant abdominal pain radiating to the back. Physical examination, blood count and routine chemistry studies were normal. Right upper quadrant ultrasound (US) showed an 8.5 cm right upper abdominal mass. Contrast enhanced abdominal computerized tomography (CT) revealed the mass as retroperitoneal with central necrosis and a hepatic dome mass (fig. 1). There were also several pulmonary nodules suspicious for metastatic disease. Given the patient’s age, gender and imaging findings, blood work and scrotal US were ordered to evaluate for an underlying testicular tumor.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Varicocele: Early Surgery versus Observation

Deciding on treatment for the fairly common (15% to 18%) asymptomatic idiopathic varicocele is a challenging problem in adolescent urology. Pediatric urologists are asked to predict the fertility future of boys who may not be attempting paternity for another decade or two. Despite numerous studies about varicocele evaluation and treatment, uncertainties remain. Overtreatment and under treatment are medically and financially costly. Expensive ultrasound, office visits and surgery must be avoided in those who do not need them, while early intervention is warranted in some to preempt the need for later assisted reproductive techniques.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

New Modulatory Pathways in Micturition Reflex Function

There is still much to learn concerning the basic science underlying micturition reflex pathways, modulation of bladder function and plasticity in these neural circuits following neural injury, disease or inflammation. In this issue of The Journal Aizawa et al (page 956) highlight this topic.1 The role of cannabinoids and the endocannabinoid system in lower urinary tract (LUT) function and dysfunction has been the focus of study for more than a decade with many laboratories focusing on components of the endocannabinoid system, including cannabinoid (CB) receptors (CB1 and CB2), their endogenous ligands and related enzymes that balance the biosynthesis and degradation of endocannabinoids and related fatty acid amides (FAAs).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

This is a preliminary report of a technology that would potentially have clinical application. It certainly might be advantageous to have a map of the neuroanatomy before surgical dissection. The technology would also seem to have application in helping define and predict neurological defects resulting from trauma and congenital malformation. The study is preliminary but the technology presented seems to hold a glimmer of potential.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Cystectomy for Refractory Hemorrhagic Cystitis: Contemporary Etiology, Presentation and Outcomes

To evaluate the clinical presentation, management and outcomes for patients undergoing cystectomy for refractory hemorrhagic cystitis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Open Conversion during Minimally Invasive Radical Prostatectomy: Impact on Perioperative Complications and Predictors from National Data

Despite increased utilization of Minimally Invasive Radical Prostatectomy (MIRP), open conversion (OC) may occur due to surgical complications, surgeon inexperience or failure to progress. Here we use nationally representative data to quantify the impact of OC compared to nonconverted MIRP and open radical prostatectomy (ORP) and identify predictors of OC.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Evaluation of Renal Mass Biopsy Risk Stratification Algorithm to Robotic Partial Nephrectomy: Could a Biopsy Have Guided Management?

We evaluated a published biopsy-directed small renal mass (SRM) management algorithm using a large cohort of patients who underwent robotic partial nephrectomy (RPN) for tumors ≤4cm in size.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Anterior Vaginal Wall Suspension Procedure for Moderate Bladder and Uterine Prolapse as a Method of Uterine Preservation

We report our experience with anterior vaginal wall suspension for moderate anterior vaginal compartment prolapse and uterine descent less than stage 2.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

FGFR3 expression in primary invasive bladder cancers and matched lymph node metastases

FGFR3 is considered a good therapeutic target in bladder cancer. However, it is not known whether the FGFR3 status of primary tumors is a surrogate for their related metastases, which must be targeted by FGFR-targeted systemic therapies. We aimed to assess FGFR3 protein expression in primary bladder tumors and matched nodal metastases.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

We agree that a multidisciplinary approach is paramount to ensure optimal outcomes. All perioperative decisions are made in concert with an anesthesia and critical care team led by a single cardiac anesthesiologist (DT) who is present for all cases. These cases are performed in a bypass ready room with a cardiothoracic surgical team readily available. In cases of minimal intra-atrial extension the cardiothoracic team assists with atriotomy (digital manipulation of the thrombus into the IVC) to allow for vascular control at the cavo-atrial junction.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

Cardiopulmonary or venous-venous bypass are often required to achieve hemodynamic stability during surgical management of RCC in patients with suprahepatic IVC tumor thrombus. Deep hypothermic circulatory arrest is an additional adjunct that may be used in cases of extensive tumor thrombus. The current authors report their experience with suprahepatic tumor thrombectomy without bypass. Overall the reported complication rate and survival are in line with those of contemporary bypass surgical series (reference 27 in article).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Compensatory Hypertrophy after Partial and Radical Nephrectomy in Adults

We assessed compensatory hypertrophy in the contralateral kidney after partial nephrectomy(PN) and radical nephrectomy(RN) in adults and examined predictive factors to facilitate more accurate estimation of global renal function after surgery.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Current Clinical Presentation and Treatment of Localized Prostate Cancer in the United States

The Surveillance, Epidemiology, and End Results (SEER) registry recently released Gleason score at the time of biopsy/TURP, which, for the first time, permits accurate assessment of the presentation and treatment of prostate cancer according to clinical factors at diagnosis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

An observational analysis of provider adherence with the AUA guidelines on the management of Benign Prostatic Hyperplasia

We retrospectively evaluated urologist adherence with the American Urological Association guidelines on the management of new patients with benign prostatic hyperplasia (BPH) related lower urinary tract symptoms (LUTS) in a large university urology group.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Following the Needles: An Anatomical Study to Evaluate the Post-Operative Safety and Symptoms of Patients Receiving a Transobturator Male Sling Implant

The implant of transobturator male slings (TOT-MS) is a valid option for the management of urinary incontinence post-prostatectomy. In the present study, the trajectory of needles blindly introduced into the retropubic space was evaluated, in order to investigate the safety and etiology of postoperative symptoms that can arise from use of Argus T™ implant.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Diabetes Mellitus is Independently Associated with an Increased Risk of Mortality Among Clear Cell Renal Cell Carcinoma Patients

Conflicting data exist regarding the interaction of diabetes mellitus (DM) with outcomes for patients with renal cell carcinoma (RCC). Herein, we evaluate the association of DM with survival among patients with clear cell RCC (ccRCC) treated with nephrectomy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Finasteride Use in the Male Infertility Population: Effects on Semen and Hormone Parameters

M. K. Samplaski, K. Lo, E. Grober and K. Jarvi

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Testosterone Use in the Male Infertility Population: Prescribing Patterns and Effects on Semen and Hormonal Parameters

M. K. Samplaski, Y. Loai, K. Wong, K. C. Lo, E. D. Grober and K. A. Jarvi

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Semen Quality and Time to Pregnancy: The Longitudinal Investigation of Fertility and the Environment Study

G. M. Buck Louis, R. Sundaram, E. F. Schisterman, A. Sweeney, C. D. Lynch, S. Kim, J. M. Maisog, R. Gore-Langton, M. L. Eisenberg and Z. Chen

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Relationship between Male BMI and Waist Circumference on Semen Quality: Data from the LIFE Study

M. L. Eisenberg, S. Kim, Z. Chen, R. Sundaram, E. F. Schisterman and G. M. Buck Louis

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Body Mass Index in Relation to Semen Quality and Reproductive Hormones in New Zealand Men: A Cross-Sectional Study in Fertility Clinics

A. A. MacDonald, A. W. Stewart and C. M. Farquhar

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Survey Finds Few Orthopedic Surgeons Know the Costs of the Devices they Implant

K. Okike, R. V. O'Toole, A. N. Pollak, J. A. Bishop, C. M. McAndrew, S. Mehta, W. W. Cross, III, G. E. Garrigues, M. B. Harris and C. T. Lebrun

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: National Health Spending in 2012: Rate of Health Spending Growth Remained Low for the Fourth Consecutive Year

A. B. Martin, M. Hartman, L. Whittle and A. Catlin; National Health Expenditure Accounts Team

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Lower Urinary Tract Symptoms in Benign Prostatic Hyperplasia Patients: Orchestrated by Chronic Prostatic Inflammation and Prostatic Calculi?

S. H. Kim, K. I. Jung, J. S. Koh, K. O. Min, S. Y. Cho and H. W. Kim

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Evaluation of Recent Trends in Treatment Patterns among Men with Benign Prostatic Hyperplasia

E. J. Kruep, B. B. Goodwin and S. Chaudhari

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Body Mass Index Predicts Failure of Surgical Management in Benign Prostatic Hyperplasia

J. M. Willder, V. C. Walker, G. L. Halbert, C. P. Dick, C. Orange, T. Qayyum, P. G. Horgan, M. A. Underwood and J. Edwards

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Risk of End-Stage Renal Disease Following Live Kidney Donation

A. D. Muzaale, A. B. Massie, M. C. Wang, R. A. Montgomery, M. A. McBride, J. L. Wainright and D. L. Segev

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Long-Term Risks for Kidney Donors

G. Mjøen, S. Hallan, A. Hartmann, A. Foss, K. Midtvedt, O. Oyen, A. Reisæter, P. Pfeffer, T. Jenssen, T. Leivestad, P. D. Line, M. Ovrehus, D. O. Dale, H. Pihlstrøm, I. Holme, F. W. Dekker and H. Holdaas

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Risk of chronic and end-stage kidney disease in people with nephrolithiasis

and Objectives: To examine kidney stone disease as a potential risk factor for chronic kidney disease (CKD), end-stage kidney disease and treatment with dialysis (ESKD).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Fully Automated Prostate Segmentation on MRI: Comparison with Manual Segmentation Methods and Specimen Volumes

B. Turkbey, S. V. Fotin, R. J. Huang, Y. Yin, D. Daar, O. Aras, M. Bernardo, B. E. Garvey, J. Weaver, H. Haldankar, N. Muradyan, M. J. Merino, P. A. Pinto, S. Periaswamy and P. L. Choyke

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: A Meta-Analysis of Patient Outcomes with Subcentimeter Disease after Chemotherapy for Metastatic Non-Seminomatous Germ Cell Tumor

P. Ravi, K. P. Gray, E. K. O'Donnell and C. J. Sweeney

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prospective Study of Polydimethylsiloxane vs Hyaluronic Acid Injection for Treatment of Vesicoureteral Reflux

Treatment of vesicoureteral reflux (VUR) with endoscopic injection of a bulking agent is becoming the first line of treatment for low grade VUR. We prospectively compared the efficacy of two products commercialised in Canada.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Fluoroquinolone Resistant Rectal Colonization Predicts Risk of Infectious Complications Following Transrectal Prostate Biopsy

Infection after transrectal prostate biopsy (TRPB) has become a growing concern due to fluoroquinolone (FQ) resistant (FQR) bacteria. We determine if colonization identified by rectal culture can identify men at high risk of post-TRPB infection.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Impact of Complications and Hospital-Free Days following Radical Cystectomy on Health-Related Quality of Life at One Year

We sought to determine the extent to which complications, as well as the number of “hospital-free days” (HFDs) within 30 and 90 days of surgery predicted HRQOL at one year following radical cystectomy (RC).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

HO Generation by Bacillus Calmette-Guérin Induces the Cellular Oxidative Stress Response Required for Bacillus Calmette-Guérin Direct Effects on Urothelial Carcinoma Biology

Exposure of urothelial carcinoma cells to bacillus Calmette-Guérin affects cellular redox status and tumor cell biology but the mechanism(s) remain unclear. We examined free radical production by bacillus Calmette-Guérin in tumor cells in response to the bacillus using global profiling of reactive oxygen species/reactive nitrogen species. The relationship between free radical generation and downstream cellular events was evaluated.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

Understanding global trends in prostate cancer is becoming increasingly important as we see an increasing incidence among populations once believed to be at lower cancer risk.1 There has been an overall decrease in the rate of infection related cancers and an increase in malignancies attributable to dietary and hormonal influences. This population based study in Ghanaian men aims to better understand the burden of prostate cancer in West Africa, a largely unscreened population, and demonstrates high prevalence in screen detected men 50 to 74 years old.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The authors performed a prostate cancer screening study in Accra, Ghana. They found a high prevalence of prostate cancer and a higher proportion of clinical stage T2 or greater and Gleason score 7 or greater disease relative to that in white and black American men.1 As the authors acknowledge, direct comparisons to the population of the United States are limited due to the higher incidence of PSA screening at baseline, which affects disease prevalence and stage at diagnosis. In addition, complex socioeconomic issues underlie the epidemiology and screening of prostate cancer in black American men as well as genetic admixture in the United States that may further confound comparison.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Erratum

Volume 189, Issue 5, Page 1860, Prospective Evaluation: The institutional review board at the study institution did not require any consent from parents as this study involved data gathered by the urology residents during their evaluation of children with testicular pain in the emergency room and did not affect their care at the time of study.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

The principal point of our study is that if a guideline group concludes that early screening is warranted in men at high risk, as is the case with AUA guidelines, risk is then better stratified by baseline PSA than by race or family history. Although our study does not directly address the value of screening in younger men, we would nonetheless like to respond to the comment that “there is no evidence that finding and treating prostate cancer in younger men … will increase life expectancy.” Application of the results of randomized trials to clinical decision making surely must be a little more nuanced than simply looking up eligibility criteria and dividing the world into 2 groups, including a group in which the intervention works and the other in which its effects are unknown.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

Prostate cancer mortality rates in 40 to 49-year-old men are miniscule compared to those in older men.1 However, guidelines suggest first discussing screening in men at high risk at ages 40 to 49 years in the hope of reducing long-term prostate cancer mortality (reference 4 in article). Interestingly the current authors found that PSA results at ages 45 to 49 years were far more predictive of mortality by age 75 years than race or family history. Nonetheless, they prudently refrained from recommending baseline PSA testing in all men before age 50 years.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Cosmetic Incision in Boys for Lower Abdominal Surgery

B. W. Snow

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: A Novel Skin Management Scheme in Surgery of Epispadias Undergoing Cantwell-Ransley Repair: A Technique to Improve the Aesthetics and Minimize Complications

S. N. Kureel, A. Gupta, C. S. Singh and J. Rawat

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Introducing the HOPE (Hypospadias Objective Penile Evaluation)-Score: A Validation Study of an Objective Scoring System for Evaluating Cosmetic Appearance in Hypospadias Patients

F. van der Toorn, T. P. de Jong, R. P. de Gier, P. R. Callewaert, E. H. van der Horst, M. G. Steffens, P. Hoebeke, R. J. Nijman, N. C. Bush, K. P. Wolffenbuttel, M. M. van den Heijkant, J. W. van Capelle, M. Wildhagen, R. Timman and J. J. van Busschbach

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Urethral Strictures Following Urethral Plate and Proximal Urethral Elevation during Proximal TIP Hypospadias Repair

W. T. Snodgrass, C. Granberg and N. C. Bush

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Superior Quality of Life and Improved Surgical Margins are Achievable with Robotic Radical Prostatectomy after a Long Learning Curve: A Prospective Single-Surgeon Study of 1552 Consecutive Cases

J. E. Thompson, S. Egger, M. Böhm, A. M. Haynes, J. Matthews, K. Rasiah and P. D. Stricker

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Preclinical Efficacy of Growth Hormone-Releasing Hormone Antagonists for Androgen-Dependent and Castration-Resistant Human Prostate Cancer

C. D. Fahrenholtz, F. G. Rick, M. I. Garcia, M. Zarandi, R. Z. Cai, N. L. Block, A. V. Schally and K. L. Burnstein

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: ELF3 is a Repressor of Androgen Receptor Action in Prostate Cancer Cells

A. Shatnawi, J. D. Norris, C. Chaveroux, J. S. Jasper, A. B. Sherk, D. P. McDonnell and V. Giguère

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prostatic Inflammation Enhances Basal-to-Luminal Differentiation and Accelerates Initiation of Prostate Cancer with a Basal Cell Origin

O. J. Kwon, L. Zhang, M. M. Ittmann and L. Xin

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Regulation of Macromolecular Modulators of Urinary Stone Formation by Reactive Oxygen Species: Transcriptional Study in an Animal Model of Hyperoxaluria

S. R. Khan, S. Joshi, W. Wang and A. B. Peck

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Heritability of Urinary Traits that Contribute to Nephrolithiasis

J. C. Lieske, S. T. Turner, S. N. Edeh, J. A. Smith and S. L. Kardia

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Urinary Lithogenic Risk Profile in Recurrent Stone Formers with Hyperoxaluria: A Randomized Controlled Trial Comparing DASH (Dietary Approaches to Stop Hypertension)-Style and Low-Oxalate Diets

N. Noori, E. Honarkar, D. S. Goldfarb, K. Kalantar-Zadeh, M. Taheri, N. Shakhssalim, M. Parvin and A. Basiri

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Demographics of Pediatric Renal Trauma

There is a lack of national data describing the demographics and nature of pediatric renal trauma. The goal of this study was to use the National Trauma Data Bank to analyze the method and grade of renal injury, demographic, and treatment characteristics of pediatric renal trauma patients.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The overlap and distinction of self-reported symptoms between interstitial cystitis/bladder pain syndrome and overactive bladder: a questionnaire-based analysis

To compare the self-reported symptoms between IC/BPS and OAB based on patient-reported symptoms on validated questionnaires.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Safety and Efficacy of a New Adjustable Single Incision Sling for Treatment of Female Stress Urinary Incontinence Through 12-months of Follow-up

The purpose of this report is to describe the safety and efficacy of the Altis® Single Incision Sling System (Altis sling) for treatment of female stress urinary incontinence through 12 months.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

Dr. Penson succinctly highlights an essential facet of future research. There is an essential need to identify the underlying processes of care associated with bladder cancer focused surgeons (and of course their institutions) that drive favorable outcomes. Applying modifiable and significant processes of care to all jurisdictions where cystectomy is performed will almost certainly improve quality of care across the board.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

This single institution, 2-hospital study provides interesting food for thought regarding methods for optimizing the quality of bladder cancer care. The authors find that patients who undergo cystectomy by surgeons with a specialized focus on bladder cancer have better long-term outcomes than those who undergo cystectomy by other urologists. Acknowledging that the results may be influenced by the temporality of the procedure, the findings are still quite thought provoking.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prospective Randomized Trial of Hexylaminolevulinate Photodynamic-Assisted Transurethral Resection of Bladder Tumour (TURBT) plus Single-Shot Intravesical Mitomycin C vs Conventional White-Light TURBT plus Mitomycin C in Newly Presenting Non-Muscle-Invasive Bladder Cancer

T. O'Brien, E. Ray, K. Chatterton, M. S. Khan, A. Chandra and K. Thomas

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Effects of Ureteral Stents on Risk of Bacteriuria in Renal Allograft Recipients

P. Chordia, D. Schain and L. Kayler

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparison of Prospective Risk Estimates for Postoperative Complications: Human vs Computer Model

R. E. Glasgow, M. T. Hawn, P. W. Hosokawa, W. G. Henderson, S. J. Min, J. S. Richman, M. G. Tomeh, D. Campbell and L. A. Neumayer; DS3 Study Group

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

Current Children's Oncology Group protocols call for primary reexcision when a transscrotal approach has been erroneously used in patients with paratesticular rhabdomyosarcoma. Concerns include residual tumor and seeding of the scrotal skin, along with involvement of an additional lymphatic drainage chain (superficial inguinal). The issue is magnified by data from our European colleagues, suggesting that an incorrect incision is a fairly common occurrence (up to 25% of cases).1 Current data on the incidence of incorrect surgical approach in patients enrolled in Children's Oncology Group studies are lacking.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Author

I appreciate the clarifications from Paital et al regarding their study, and I certainly agree that there should be more rigorous regulatory control for homeopathic preparations before widespread use. Nevertheless, notwithstanding this particular study, we as consumers and prescribing physicians are left to deal with an environment that promotes and sells many of these remedies. We must continue to be diligent and forthright in letting the medical community know when we are troubled or concerned about particular studies, as well as being unrelenting in critiquing those who will continue to peddle products based on poorly substantiated claims.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Comparison of Perioperative Outcomes Including Severe Bladder Injury Between Monopolar and Bipolar Transurethral Resection of Bladder Tumors: A Population-Based Comparison

This study used nationwide population-based data to compare perioperative outcomes, including severe bladder injury, between monopolar and bipolar transurethral resection of bladder tumors (M-TURBT and B-TURBT).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Identification of Different Phenotypes of Interstitial Cells in the Upper and Deep Lamina Propria of the Human Bladder Dome

There is increasing evidence for an important role of the lamina propria in bladder physiology and interstitial cells seem to have a key role in this area. Interstitial cells in the upper lamina propria have been studied most frequently. We characterized interstitial cells in the deeper lamina propria and hypothesized that the 2 interstitial cell populations have different phenotypes based on their ultrastructural and immunohistochemical properties.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Editorial Comment on Constitutional, Organopathic and Combined Homeopathic Treatment of Begin Prostatic Hypertrophy: A Clinical Trial

In developing countries such as India the majority of people usually ignore health related issues and only consult physicians when they reach an unbearable or unmanageable state of disease. The reasons are related to negligence of diseases, lack of health awareness and mostly poor economic status. Access to free treatment can induce patients to rush to the hospital. Therefore, we were able to enroll a high number of patients in our study only after advertising free treatment for benign prostatic hyperplasia (BPH) in the newspapers.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Beneficial Effects of Renin-Angiotensin System Blockers on Testicular Steroidogenesis

The goal of this study was to evaluate whether antihypertensive drugs that act through the renin-angiotensin system (RAS) affect the testis function.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Surgical Management of Kidney Stone Disease: A Population-Based Time Series Analysis

To evaluate population-based trends in the use of extracorporeal shockwave lithotripsy (SWL), ureteroscopy (URS) and percutaneous nephrolithotomy (PCNL) over the past 20 years, as well as assessing retreatment rate and morbidity from treatment over time.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

MiRNA-34a Suppresses Cell Proliferation and Metastasis by Targeting CD44 in Human Renal Carcinoma Cells

We investigated the potential functions of miR-34a in CD44 transcriptional complexes in renal cell carcinoma.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A High-Throughput Minimally-Invasive, Ultrasound-Guided Model For The Study Of Catheter Associated Urinary Tract Infections And Device Encrustation In Mice

Catheter-associated urinary tract infections (CAUTI) are one of the most common healthcare-associated infections frequently complicated by encrustation, causing blockage of the catheter lumen. Preclinical research is limited by the lack of relevant high-throughput and cost effective animal models. Current models are restricted to female mice, associated with major transurethral loss of catheter materials during micturition, highly invasive and complex. We present an ultrasound-guided, minimally-invasive model enabling CAUTI and catheter encrustation studies in both genders of mice.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Incidence of Infectious Complications after Extracorporeal Shock Wave Lithotripsy in Patients Without Associated Risk Factors

To determine the incidence of infectious complications (asymptomatic bacteriuria, urinary tract infection and urosepsis) in subjects without associated risk factors treated with extracorporeal shock wave lithotripsy (SWL).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prospective evaluation of MRI-guided in-bore prostate biopsy versus systematic transrectal ultrasound (TRUS)-guided prostate biopsy in biopsy-naïve men with elevated prostate-specific antigen (PSA) levels

MRI-guided biopsies are increasingly used for prostate cancer (PCa) diagnosis. However, there is a lack of well controlled prospective trials to support this treatment method. The aim of this study was to prospectively compare the MRI-guided in-bore biopsy with the standard systematic TRUS-guided biopsy in biopsy naïve men with elevated PSA.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The authors are to be commended for tackling the important and timely topic of resource utilization associated with the diagnostic evaluation of infants with isolated primary nonrefluxing hydronephrosis. The article has 2 important messages for readers. First, it is unnecessary to investigate and follow patients with SFU grade I hydronephrosis after the initial diagnosis. SFU grade I hydronephrosis has a benign course and should be regarded as a normal variant of a physiological state, not as a medical condition that necessitates surveillance.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Anticoagulation and Antiplatelet Therapy in Urological Practice: ICUD/AUA Review Paper

Given the lack of urology specific directives for the periprocedural management of anticoagulant and antiplatelet medications, AUA and ICUD named an international multidisciplinary panel to develop consensus based recommendations.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prospective Trial for the Detection of Urolithiasis at Ultra-low-dose (Sub-mSv) Non-contrast CT: Direct Comparison against Routine Low-dose Reference Standard

The purpose of this prospective trial was to compare the performance of ultra-low-dose computed tomography (CT) reconstruction algorithms with routine low-dose CT for the detection of urolithiasis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Low detectable PSA after radical prostatectomy: treat or watch?

To determine whether the pattern of low detectable prostate-specific antigen (PSA) during the first 3 years of follow-up after radical prostatectomy (RP) is a predictor for subsequent biochemical recurrence (BCR).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prospective External Validation of Model for Bladder Cancer Detection

Few studies have combined clinical prognostic factors with urinary biomarkers into risk profiles that can be used to predict the likelihood of bladder cancer. We previously developed and internally validated a bladder cancer detection nomogram that combines clinical features with the NMP22 BladderChek® test (NMP22). In order to consider extensive use of the model, the nomogram was tested among a prospective cohort of patients presenting with hematuria.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Dietary Intake of Fiber, Fruit, and Vegetables Decrease the Risk of Incident Kidney Stones in Women: A Women’s Health Initiative (WHI) Report

We evaluated the relationship between dietary fiber, fruit, and vegetable intake, and the risk of kidney stone formation.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Evolution of Urethroplasty for Bulbar Urethral Stricture Disease: Lessons Learned from a Single Center Experience

We reviewed the evolution of repairs for bulbar urethral stricture disease and analyzed changes in outcomes.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Elevated Serum IgE May Be Associated with Development of Ketamine Cystitis

Previous studies revealed bladder mast cell and eosinophil cell infiltration in patients with ketamine cystitis. Due to possible hypersensitivity in those with this condition we investigated the association of serum Ig, histology findings and symptoms in patients with ketamine cystitis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prevention of Kidney Stones: A Call for More Evidence-Based Research

Many physiological and metabolic disorders have been implicated in the etiology of kidney stone formation, and the ability to differentiate among the principal abnormalities allows presentation of a selective treatment program on the basis of correction of the specific physiological disorder. Over the years tailored treatments were created that contained the 3 different components of high fluid intake, individual diet and medication. The AUA guideline on the Medical Management of Kidney Stones provides a timely clinical framework for the diagnosis, prevention and followup of adults with kidney stones based on the best available published literature up to November 2012.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Urotrauma Guidelines

The American Urological Association has released the Urotrauma Guidelines which are intended to serve as a guide for clinicians in the evaluation and management of genitourinary injuries. This valuable document is based on the literature since 1990 with levels of evidence using a strength rating. This is the first guideline released by the AUA on Urotrauma.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

AUA Guideline on the Diagnosis and Treatment of Cryptorchidism

Cryptorchidism is one of the most common male pediatric urological conditions, and one that can have a lifelong effect if not managed appropriately. The evaluation and treatment of cryptorchidism have progressed significantly during the last several decades, as the condition has been studied extensively. While we now have a much better understanding of the pathogenesis and sequelae of undescended testes (UDTs), our knowledge remains incomplete. Given the breadth of studies performed in the last 3 decades examining the many pathogenetic factors contributing to cryptorchidism, as well as the availability of numerous hormonal and surgical treatment options, a comprehensive consensus statement was necessary.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Medical Management of Kidney Stones: AUA Guideline

The purpose of this guideline is to provide a clinical framework for the diagnosis, prevention and follow-up of adult patients with kidney stones based on the best available published literature.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Evaluation and Treatment of Cryptorchidism: AUA Guideline

Cryptorchidism is one of the most common pediatric disorders of the male endocrine glands and the most common genital disorder identified at birth. This guideline is intended to provide physicians and non-physician providers (primary care and specialists) with a consensus of principles and treatment plans for the management of cryptorchidism (typically isolated non-syndromic).

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Urotrauma: AUA Guideline

The authors of this guideline reviewed the urologic trauma literature to guide clinicians in the appropriate methods of evaluation and management of genitourinary injuries.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Impact of Seat Belts and Airbags on High Grade Renal Injuries and Nephrectomy Rate in Motor Vehicle Collisions

Motor vehicle collisions are the most common cause of blunt genitourinary trauma. We compared renal injuries with no protective device to those with seat belts and/or airbags using NTDB. Our primary end point was a decrease in high grade (grades III-V) renal injuries with a secondary end point of a nephrectomy rate reduction.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Histopathological Evaluation of Orchiectomy Specimens in 51 Late Postpubertal Men with Unilateral Cryptorchidism

We evaluate the histopathological features of uncorrected undescended testis presenting at a late postpubertal age.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Correlation of Gene Expression with Bladder Capacity in Interstitial Cystitis/Bladder Pain Syndrome

Interstitial cystitis and bladder pain syndrome are terms used to describe a heterogeneous chronic pelvic and bladder pain disorder. Despite its significant prevalence our understanding of disease etiology is poor. We molecularly characterized interstitial cystitis/bladder pain syndrome and determined whether there are clinical factors that correlate with gene expression.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Effect of Stachydrine on the Expression of Caspase-12 in Rats with Unilateral Ureteral Obstruction

We studied the effect of stachydrine on the expression of caspase-12 and 9 in rats with unilateral ureteral obstruction.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Transient Increase in Circulating Myeloid Derived Suppressor Cells after Partial Bladder Outlet Obstruction

Partial bladder outlet obstruction causes a significant increase in tissue and systemic oxidative stress markers and tissue inflammatory cytokine levels. Myeloid-derived suppressor cells, IFN-γ, IL-10 and aldosterone are believed to be associated with oxidative stress and inflammation. We investigated alterations in plasma myeloid-derived suppressor cells, IFN-γ, IL-10 and aldosterone levels in partial bladder outlet obstruction and after its reversal.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Vasectomy Reversal Outcomes among Patients with Vasal Obstructive Intervals Greater than 10 Years

E. D. Grober, E. Karpman and M. Fanipour

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Microsurgical Vasoepididymostomy is an Effective Treatment for Azoospermic Patients with Epididymal Obstruction and Prior Failure to Achieve Pregnancy by Sperm Retrieval with Intracytoplasmic Sperm Injection

J. Peng, Y. Yuan, Z. Zhang, W. Cui, W. Song and B. Gao

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Microdissection Testicular Sperm Extraction and Salvage Hormonal Treatment in Patients with Postchemotherapy Azoospermia

K. Shiraishi and H. Matsuyama

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparison of Sperm Retrieval and Intracytoplasmic Sperm Injection Outcome in Patients with and without Klinefelter Syndrome

M. Sabbaghian, T. Modarresi, H. Hosseinifar, J. Hosseini, F. Farrahi, F. Dadkhah, M. Chehrazi, G. Khalili and M. A. Sadighi Gilani

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Impact of Fresh versus Cryopreserved Testicular Sperm upon Intracytoplasmic Sperm Injection Pregnancy Outcomes in Men with Azoospermia due to Spermatogenic Dysfunction: A Meta-Analysis

S. Ohlander, J. Hotaling, E. Kirshenbaum, C. Niederberger and M. L. Eisenberg

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Impact of Graft Position on Failure of Single-Stage Bulbar Urethroplasties with Buccal Mucosa Graft

B. D. Figler, B. S. Malaeb, G. W. Dy, B. B. Voelzke and H. Wessells

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Pyocystis after Urinary Diversion for Incontinence—Is a Concomitant Cystectomy Necessary?

A. Lawrence, B. Hu, O. Lee and A. Stone

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: External Validation of a Substratification of the American Association for the Surgery of Trauma Renal Injury Scale for Grade 4 Injuries

B. D. Figler, B. S. Malaeb, B. Voelzke, T. Smith and H. Wessells

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Effect of Benign Lower Urinary Tract Symptoms on Subsequent Prostate Cancer Testing and Diagnosis

C. J. Weight, S. P. Kim, D. J. Jacobson, M. E. McGree, S. A. Boorjian, R. H. Thompson, B. C. Leibovich, R. J. Karnes and J. St. Sauver

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Development of a Quality of Life Scale Specific for Patients with Benign Prostatic Hyperplasia

K. Cam, T. Muezzinoglu, O. Aydemir, R. Buyukalpelli, G. Toktas and H. Gemalmaz

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Use of the SF-36 Quality of Life Scale to Assess the Effect of Pelvic Floor Muscle Exercise on Aging Males who Received Transurethral Prostate Surgery

C. P. Hou, T. Y. Chen, C. C. Chang, Y. H. Lin, P. L. Chang, C. L. Chen, Y. C. Hsu and K. H. Tsui

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The authors report their unique 12-year experience with thermal ablation for local control of mRCC lesions. Oncologic outcomes at up to 3 years were acceptable. However, these should be interpreted in the context of receipt of systemic therapy before and after ablation in a significant number of patients. Complication rates were low. The ablation outcomes are at least comparable to those for surgical metastectomy in a similar patient cohort (reference 13 in article). This article is significant in that it demonstrates feasibility of thermal ablation as an effective and safe treatment alternative to surgical metastectomy in the treatment of mRCC.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

We will continue the careful followup of this cohort to determine the long-term outcomes. Although this nonseeded scaffold is easy to use in clinical practice, we also note that any kind of patch is likely to shrink, leading to reduced capacity and increased pressure in the long term. More cases are being accumulated at our department, and we look forward to reporting the long-term results of this technology in the future.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

Experimental work investigating tissue engineered patches using a variety of scaffolding materials continues to blossom in the laboratory and in the clinical arena. The authors have assiduously studied the use of SIS as the molding agent, providing seemingly good results after a minimum of 1-year followup. Their reservedness of waiting this interval in their 8 patients before reporting on the effectiveness of this particular patch is commendable. It provides the reader with some hope that eventually this technique will be a viable and routine alternative to enteric augmentation.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Screening for Prostate Cancer with the Prostate-Specific Antigen Test: A Review of Current Evidence

J. H. Hayes and M. J. Barry

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Examining Long-Term Outcomes of Bladder Exstrophy: A 20-Year Follow-up

A. D. Gupta, S. K. Goel, C. R. Woodhouse and D. Wood

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Gender-Related Fetal Development of the Internal Urethral Sphincter

J. Oswald, I. Heidegger, E. Steiner, E. Brenner, M. Ladurner Rennau, R. Pichler, T. Becker, W. Loidl, W. Horninger and H. Fritsch

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Relationships between Renal Compensatory Hypertrophy Etiologic Factors and Anthropometric Development in the Pediatric Age Group

D. Alaygut, A. Soylu, B. Kasap, M. Türkmen, H. Cakmakcı and S. Kavukcu

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Failed Pyeloplasty in Children: Revisiting the Unknown

R. L. Romao, M. A. Koyle, J. L. Pippi Salle, A. Alotay, V. H. Figueroa, A. J. Lorenzo, D. J. Bagli and W. A. Farhat

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Paratesticular Serous Papillary Borderline Tumor

A 37-year-old male presented with a 2-year history of progressive left scrotal swelling. Ultrasound showed an enlarged left testicle with heterogeneous echogenicity. Serum α-fetoprotein (AFP) and β-human chorionic gonadotropin were negative. There was no evidence of metastatic disease on computerized tomography. Left radical inguinal orchiectomy was performed.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Home Study Course 2014 Volume 191/192

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Grade IV Renal Trauma Managed in a Nonoperative Fashion—Is There a Benefit to Preemptive Endoscopic and/or Radiographic Intervention?

The nonoperative (conservative) management of clinically stable patients with grade IV traumatic renal injuries is currently the standard of urological care. Complications requiring interventional management by endoscopic or radiographic means will occur on average in 40% of patients, with 5% needing an open operative intervention for the management of urological complications.1–8 Long-term followup shows that more than 95% of cases managed with a nonoperative protocol will retain more than 20% differential renal function of the involved kidney.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Management of Complications and Residual Symptoms in Men with an Artificial Urinary Sphincter

The artificial urinary sphincter (AUS) has long been considered the gold standard treatment for male stress urinary incontinence. Efficacy and satisfaction rates are high as long as patients have a working AUS in place.1 Various complications can occur with an AUS, but these can be effectively managed via a systematic approach with restoration of patient satisfaction.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Promise of Tissue Engineering in Urology

In this issue of The Journal 2 articles highlight how the field of tissue engineering, or what is now commonly referred to as regenerative medicine, is beginning to impact clinical urology. Zhang and Liao (page 544) demonstrated that 4-layer small intestinal submucosa (SIS) can be used in the unseeded technique to augment small neurogenic bladders.1 Six patients received SIS augmentation and all 6 had improvement in capacity and compliance.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Bioactive Exosomes: Possibilities for Diagnosis and Management of Bladder Cancer

Bladder cancer is the most expensive cancer per patient due in part to reliance on frequent cystoscopy for monitoring recurrence.1 Accurate urinary biomarkers that detect recurrence, progression or invasiveness could simultaneously reduce costs and improve patient experiences.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Investigative Urology

Beckham et al (page 583) from Rochester, New York and Taiwan studied how exosomes may affect high grade bladder cancer (HGBC), an extremely aggressive malignancy associated with high morbidity and mortality.1 They assessed exosomes derived from human bladder cancer cell lines and the urine of patients with HGBC for the ability to promote cancer progression in standard assays. Exosomes purified from a HGBC and a nonmalignant urothelial cell line were submitted for mass spectrometry. EDIL-3 was identified and selected for further analysis.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Phyllodes Tumor of the Seminal Vesicle

A 54-year-old man presented with acute right flank pain. He reported no other genitourinary symptoms and medical history was significant only for hypertension. There was no palpable abdominal mass on examination or hematuria.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Pediatric Urology

Many pediatric urologists are involved in international mission trips where they often treat primarily genital anomalies. Hypospadias is a condition most frequently treated in these developing countries. There is always a balance between providing surgical care for untreated anomalies versus trying to train the local physicians to perform the techniques and improve the standard of care. Metzler et al (page 524) from Massachusetts and California assess the success of their training efforts after mission trips to Viet Nam and Senegal.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Adult Urology

Some reports going back a decade ago proposed that injection of skeletal muscle cells along the urethra may be used to treat stress urinary incontinence. However, reproducibility, function and viability of this regenerative tissue engineering approach were issues. In this multi-institutional industry trial of autologous muscle derived cells Peters et al (page 469) pooled 2 phase I/II studies of women with refractory stress incontinence.1 They performed a dose ranging study from 10 to 200 × 106 autologous cells derived from biopsies of the quadriceps femoris in 80 patients, and safety was the primary outcome.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prevalence of Commonly Prescribed Medications Potentially Contributing to Urinary Symptoms in a Cohort of Older Patients Seeking Care for Incontinence

M. Kashyap, L. M. Tu and C. Tannenbaum

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Chronic Administration of Anticholinergics in Rats Induces a Shift from Muscarinic to Purinergic Transmission in the Bladder Wall

P. Uvin, M. Boudes, A. Menigoz, J. Franken, S. Pinto, T. Gevaert, R. Verplaetse, J. Tytgat, R. Vennekens, T. Voets and D. De Ridder

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: TVT-O for the Treatment of Pure Urodynamic Stress Incontinence: Efficacy, Adverse Effects, and Prognostic Factors at 5-Year Follow-up

M. Serati, R. Bauer, J. N. Cornu, E. Cattoni, A. Braga, G. Siesto, D. Lizée, F. Haab, M. Torella and S. Salvatore

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: A Systematic Review of Surgical Techniques Used in the Treatment of Female Urethral Stricture

N. I. Osman, A. Mangera and C. R. Chapple

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Role of Phosphodiesterases in Bladder Pathophysiology

M. S. Rahnama'i, S. Ückert, R. Hohnen and G. A. van Koeveringe

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Likelihood of Death from Prostate Cancer in Men with Favorable or Unfavorable Intermediate-Risk Disease

F. K. Keane, M. H. Chen, D. Zhang, M. J. Loffredo, P. W. Kantoff, A. A. Renshaw and A. V. D’Amico

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Denosumab and Bone Metastasis-Free Survival in Men with Nonmetastatic Castration-Resistant Prostate Cancer: Exploratory Analyses by Baseline Prostate-Specific Antigen Doubling Time

M. R. Smith, F. Saad, S. Oudard, N. Shore, K. Fizazi, P. Sieber, B. Tombal, R. Damiao, G. Marx, K. Miller, P. Van Veldhuizen, J. Morote, Z. Ye, R. Dansey and C. Goessl

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Clinical Performance of Serum Isoform proPSA (p2PSA) and its Derivatives, Namely %p2PSA and PHI (Prostate Health Index) in Men Younger than 60 Years of Age: Results from a Multicentric European Study

N. Fossati, M. Lazzeri, A. Haese, T. McNicholas, A. de la Taille, N. M. Buffi, G. Lughezzani, G. M. Gadda, G. Lista, A. Larcher, A. Abrate, F. Mistretta, V. Bini, J. P. Redorta, M. Graefen and G. Guazzoni

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Radical Prostatectomy or Watchful Waiting on Early Prostate Cancer

A. Bill-Axelson, L. Holmberg, H. Garmo, J. R. Rider, K. Taari, C. Busch, S. Nordling, M. Häggman, S. O. Andersson, A. Spångberg, O. Andrén, J. Palmgren, G. Steineck, H. O. Adami and J. E. Johansson

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Evaluation of a Rural Nurse-Led Clinic for Female Sexual Dysfunction

C. Hakanson, C. Douglas, J. Robertson and L. Lester

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Effect of Vaginal Pelvic Organ Prolapse Surgery on Sexual Function

D. Ulrich, P. Dwyer, A. Rosamilia, Y. Lim and J. Lee

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Clitoral Size and Location in Relation to Sexual Function Using Pelvic MRI

S. H. Oakley, C. M. Vaccaro, C. C. Crisp, M. V. Estanol, A. N. Fellner, S. D. Kleeman and R. N. Pauls

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Survivorship: Sexual Dysfunction (Female), Version 1.2013

C. S. Denlinger, R. W. Carlson, M. Are, K. S. Baker, E. Davis, S. B. Edge, D. L. Friedman, M. Goldman, L. Jones, A. King, E. Kvale, T. S. Langbaum, J. A. Ligibel, M. S. McCabe, K. T. McVary, M. Melisko, J. G. Montoya, K. Mooney, M. A. Morgan, T. O’Connor, E. D. Paskett, M. Raza, K. L. Syrjala, S. G. Urba, M. T. Wakabayashi, P. Zee, N. McMillian and D. Freedman-Cass

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparative Patient-Centered Outcomes (Health State and Adverse Sexual Symptoms) between Adjuvant Brachytherapy versus No Adjuvant Brachytherapy in Early Stage Endometrial Cancer

S. Damast, K. Alektiar, A. Eaton, N. K. Gerber, S. Goldfarb, S. Patil, R. Jia, M. Leitao, J. Carter and E. Basch

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Personal Factors that Contribute to or Impair Women's Ability to Achieve Orgasm

B. B. de Lucena and C. H. Abdo

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Surgical Site Infections Following Ambulatory Surgery Procedures

P. L. Owens, M. L. Barrett, S. Raetzman, M. Maggard-Gibbons and C. A. Steiner

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparative Effectiveness of Skin Antiseptic Agents in Reducing Surgical Site Infections: A Report from the Washington State Surgical Care and Outcomes Assessment Program

T. W. Hakkarainen, E. P. Dellinger, H. L. Evans, F. Farjah, E. Farrokhi, S. R. Steele, R. Thirlby and D. R. Flum; Surgical Care and Outcomes Assessment Program Collaborative

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prognostic Significance of Venous Tumour Thrombus Consistency in Patients with Renal Cell Carcinoma (RCC)

V. L. Weiss, M. Braun, S. Perner, A. Harz, R. Vorreuther, G. Kristiansen, S. C. Müller and J. Ellinger

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Renal Function after Nephron-Sparing Surgery versus Radical Nephrectomy: Results from EORTC Randomized Trial 30904

E. Scosyrev, E. M. Messing, R. Sylvester, S. Campbell and H. Van Poppel

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Anticholinergic Drug Use, Serum Anticholinergic Activity, and Adverse Drug Events among Older People: A Population-Based Study

P. Lampela, P. Lavikainen, J. A. Garcia-Horsman, J. S. Bell, R. Huupponen and S. Hartikainen

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparison of Radical Cystectomy with Conservative Treatment in Geriatric (≥80) Patients with Muscle-Invasive Bladder Cancer

T. Martini, R. Mayr, C. Wehrberger, C. Dechet, M. Lodde, S. Palermo, E. Trenti, E. Comploj, A. Pycha and S. Madersbacher

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Effect of Melatonin on Chronic Bladder-Ischaemia-Associated Changes in Rat Bladder Function

M. Nomiya, D. M. Burmeister, N. Sawada, L. Campeau, M. Zarifpour, O. Yamaguchi and K. E. Andersson

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Overtreatment of Presumed Urinary Tract Infection in Older Women Presenting to the Emergency Department

L. B. Gordon, M. J. Waxman, L. Ragsdale and L. A. Mermel

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Dietary Sources of N-Nitroso Compounds and Bladder Cancer Risk: Findings from the Los Angeles Bladder Cancer Study

C. E. Catsburg, M. Gago-Dominguez, J. M. Yuan, J. E. Castelao, V. K. Cortessis, M. C. Pike and M. C. Stern

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Carvedilol Efficiently Protects Kidneys without Affecting the Antitumor Efficacy of Cisplatin in Mice

M. A. Carvalho Rodrigues, M. C. Silva Faria, N. A. Santos, G. C. Gobe and A. C. dos Santos

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Long Noncoding RNA SChLAP1 Promotes Aggressive Prostate Cancer and Antagonizes the SWI/SNF Complex

J. R. Prensner, M. K. Iyer, A. Sahu, I. A. Asangani, Q. Cao, L. Patel, I. A. Vergara, E. Davicioni, N. Erho, M. Ghadessi, R. B. Jenkins, T. J. Triche, R. Malik, R. Bedenis, N. McGregor, T. Ma, W. Chen, S. Han, X. Jing, X. Cao, X. Wang, B. Chandler, W. Yan, J. Siddiqui, L. P. Kunju, S. M. Dhanasekaran, K. J. Pienta, F. Y. Feng and A. M. Chinnaiyan

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Care transitions between hospitals are associated with treatment delay for patients with muscle invasive bladder cancer

Hypothesizing that changing hospitals between diagnosis and definitive therapy (care transition) may delay timely treatment, our objective was to identify the association between care transitions and treatment delay ≥3 months in patients with muscle invasive bladder cancer (MIBC).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Gender Disparities in Hematuria Evaluation and Bladder Cancer Diagnosis: A Population Based Analysis

Men are diagnosed with bladder cancer at 3 times the rate of women. However, women present with advanced disease and have poorer survival, suggesting delays in bladder cancer diagnosis. Hematuria is the presenting symptom in most cases. We assessed gender differences in hematuria evaluation in older adults with bladder cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Unilateral Ureteral Reimplantation and Management of Contralateral Low Grade or Resolved VUR

Many reports discuss new contralateral vesicoureteral reflux (VUR) after unilateral ureteral reimplantation (UR). The management of high grade VUR with resolved contralateral VUR (C-VUR) is less extensively studied. A bilateral procedure is commonly performed by most surgeons. The purpose of this study is to report the outcomes when an open procedure was deferred on the contralateral side.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Temporal Pattern of Vesicoureteral Reflux on Voiding Cystourethrogram Correlates with Dynamic Endoscopic Hydrodistention Grade of the Ureteral Orifice

Double HIT (hydrodistention implantation technique) utilizes ureteral hydrodistention (HD) to visualize injection site(s) and determine bulking agent volume. Along with grade, early vesicoureteral reflux (VUR) on voiding cystourethrogram (VCUG) provides prognostic information regarding spontaneous resolution. We hypothesized that VUR timing is predictive of endoscopic HD grade.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Mechanisms of Pelvic Organ Cross-Talk: Impact of Urethral Ligation on the Inhibitory Rectovesical Reflex

The existence of an inhibitory rectovesical reflex elicited by noxious colorectal afferent input was previously documented in an isovolumetric cystometry model with a ligated urethra. We compared the effect of noxious colorectal distension on bladder cystometry with an open and a ligated urethra.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparing Radiation Exposure between Ablative Therapies for Small Renal Masses

D. C. Arnold, II, G. Schroeder, J. C. Smith, I. N. Wahjudi, J. P. Heldt, G. D. Richards, G. Agarwal, W. G. Brisbane, D. V. Farley and D. D. Baldwin

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparative Analysis of Vascular Bulldog Clamps Used in Robot-Assisted Partial Nephrectomy

B. Le, R. S. Matulewicz, S. Eaton, K. Perry and R. B. Nadler

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Active Surveillance: Does Serial Prostate Biopsy Increase Histological Inflammation?

A. S. Glass, S. P. Porten, M. Bonham, T. C. Tran, J. E. Cowan, S. Punnen, J. M. Chan and P. R. Carroll

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prostate Specific Antigen Enhances the Innate Defence of Prostatic Epithelium against Escherichia coli Infection

C. L. Townes, A. Ali, N. Gross, D. Pal, S. Williamson, R. Heer, C. N. Robson, R. S. Pickard and J. Hall

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Age-Dependent Association between Dickkopf-1 and Calcium-Containing Urolithiasis

Y. C. Jou, Y. S. Tsai, H. Y. Hsieh, C. H. Shen, C. Y. Fang, S. Y. Chen, M. F. Lin, F. H. Chen and C. D. Hsu

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Stone Disease in Living-Related Renal Donors: Long-Term Outcomes for Transplant Donors and Recipients

E. Rizkala, S. Coleman, C. Tran, W. Isac, S. M. Flechner, D. Goldfarb and M. Monga

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Non-O Blood Type is Associated with an Increased Risk of Venous Thromboembolism after Radical Cystectomy

J. K. Wang, S. A. Boorjian, I. Frank, R. F. Tarrell, P. Thapa, E. K. Jacob, C. D. Tauscher and M. K. Tollefson

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: MR Imaging of Prostate Cancer in Radiation Oncology: What Radiologists Need to Know

P. Boonsirikamchai, S. Choi, S. J. Frank, J. Ma, K. M. Elsayes, H. Kaur and H. Choi

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Primary Retroperitoneal Lymph Node Dissection in Low-Stage Testicular Germ Cell Tumors: A Detailed Pathologic Study with Clinical Outcome Analysis with Special Emphasis on Patients who did Not Receive Adjuvant Therapy

H. A. Al-Ahmadie, B. S. Carver, A. M. Cronin, S. Olgac, S. K. Tickoo, S. W. Fine, A. Gopalan, J. Stasi, F. Rabbani, G. J. Bosl, J. Sheinfeld and V. E. Reuter

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Decline in Living Kidney Donation in the United States: Random Variation or Cause for Concern?

J. R. Rodrigue, J. D. Schold and D. A. Mandelbrot

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Financial Impact of Surgical Site Infections on Hospitals: The Hospital Management Perspective

J. Shepard, W. Ward, A. Milstone, T. Carlson, J. Frederick, E. Hadhazy and T. Perl

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Persistence of 1,25D-Induced Hypercalciuria in Alendronate Treated Genetic Hypercalciuric Stone-Forming Rats Fed a Low Calcium Diet

K. K. Frick, J. R. Asplin, C. D. Culbertson, I. Granja, N. S. Krieger and D. A. Bushinsky

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This book is a short but useful compendium of surgical management strategies for post-prostatectomy incontinence. Perforce this review is heavily based on variations of the male sling and artificial urinary sphincter. The book assiduously summarizes experience with the various male slings currently available from the standpoint of outcomes as well as surgical nuances.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Survival Analysis of Pure Seminoma at Postchemotherapy Retroperitoneal Lymph Node Dissection

Viable seminoma encountered at postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for pure testicular seminoma is rare due to the chemosensitivity of this germ cell tumor (GCT). The purpose of this study is to define the natural history of viable seminoma at PC-RPLND.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Efficacy and safety of sirolimus for renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: a systematic review

To evaluate the efficacy and safety of sirolimus in the treatment of renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Definition for Biochemical Success Following Primary Whole Gland Prostate Cryoablation

To identify evidence based definition of biochemical success following primary whole gland prostate cryoablation.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Cytokine Expression in Patients with Bladder Pain Syndrome/Interstitial Cystitis ESSIC Type 3C

Bladder wall nitric oxide production in patients with bladder pain syndrome type 3C is increased compared to undetectable nitric oxide in patients with nonHunner bladder pain syndrome and healthy controls. However, the underlying mechanism/s of the increased nitric oxide production is largely unknown. We compared mRNA expression of a select group of cytokines in patients with bladder pain syndrome/interstitial cystitis type 3C and in pain-free controls.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Nationwide Population Based Study of Infections after Transrectal Ultrasound Guided Prostate Biopsy

Transrectal ultrasound guided biopsy is the gold standard for detecting prostate cancer but international reports suggest that increasing risks are associated with the procedure. We estimated incidence and risk factors for infection after prostate biopsy as well as 90-day mortality using a nationwide Swedish sample.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

This study provides further validation of the value of the CCP score in the management of clinically localized prostate cancer. Three cohorts of men treated with RP were analyzed and the primary end point was BCR. The novel aspect of this study is that the CCP score was determined from needle biopsy and not the full RP specimen, as in previous studies (references 10 and 12). In 2 cohorts the actual diagnostic needle biopsy was used and in the third cohort a simulated biopsy from the RP specimen was used.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

Gonadal differentiation is orchestrated by a complex array of transcriptional regulators. Many of these factors have been identified through painstaking genetic analyses of a large number of affected families. The most well-known testis differentiation factor, SRY, was identified in this manner. Nevertheless, only 20% of patients with DSD have a known molecular abnormality. More recently, sophisticated high throughput genetic tools have become available and may be applied to sporadic cases.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Vesical Preservation in Patients with Late Bladder Exstrophy Referral: Histological Insights into Functional Outcome

We evaluated bladder growth after combined bladder and epispadias repair in children 5 years or older, and correlated the histological findings with final surgical outcomes.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

MRI-ultrasound fusion biopsy for prediction of final prostate pathology

To explore the impact of MRI-ultrasound (MRI-US) fusion prostate biopsy on prediction of final surgical pathology.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The authors report on children with blunt grade IV renal trauma, and a few of their findings are especially noteworthy. The study reveals a new risk factor for intervention, ie collecting system clot, seen as filling defects on CT. We and others have noted that collective system obstruction is associated with poor outcome (reference 16 in article),1 although in this series even incidentally observed clot predicted the need for intervention in 100% of patients. These patients largely needed only stents, and the renal salvage rates and need for operative intervention appear unchanged from a similar previously reported rate of 12%.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Impact of Statin Use on Oncologic Outcomes in Patients with Urothelial Carcinoma of the Bladder Treated with Radical Cystectomy

This article regarding the influence of statin use on the oncologic outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy is characterized by a clear methodology. However, in studies demonstrating the results of statins on cancer related outcomes aspirin use must also be mentioned, since it is often prescribed along with statins and may affect recurrence-free and cancer specific survival.1 In this series no data were given about aspirin use, and that is a limitation of the study.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Association of Oncofetal Protein Expression with Clinical Outcomes in Patients with Urothelial Carcinoma of the Bladder

In this study the authors analyzed 4 oncofetal proteins (IMP3, MAGE-A, glypican-3 and TPBG) in a large number of paraffin embedded tumor samples from patients with bladder cancer (BC) treated with radical cystectomy. They identified IMP3 expression as a significant risk factor for cancer specific mortality. This finding is in accordance with our study performed in a similar patient cohort using the same antibody.1 The only difference between the results of the 2 studies is that Xylinas et al found a correlation between IMP3 expression and cancer specific mortality only by univariable analysis, while in our study high IMP3 expression proved to be an independent risk factor for cancer specific mortality.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Intravenous or Local Injections of Flavoxate in the Rostral Pontine Reticular Formation Inhibit Urinary Frequency Induced by Activation of Medial Frontal Lobe Neurons in Rats

The rostral pontine reticular formation has a strong inhibitory effect on micturition by facilitating lumbosacral glycinergic neurons. We assessed the influence of the rostral pontine reticular formation on the micturition reflex after noradrenaline injection in the medial frontal lobe. We also examined the relation between the medial frontal lobe and the rostral pontine reticular formation.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Feasibility of Integrating Research Data Collection into Routine Clinical Practice Using the Electronic Health Record

The electronic health record is becoming central to routine medical practice and has the potential to facilitate large scale clinical research. We evaluated the completeness and accuracy of data collection using designated research fields integrated into a semistructured clinical note. We hypothesized that prospective research data collection as part of routine clinical charting is feasible, with a high rate of utilization (greater than 80%) and accuracy (kappa greater than 0.80).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Routine Pathology Evaluation of Hydrocele and Spermatocele Specimens Is Associated with Significant Costs and No Identifiable Benefit

Hydrocelectomy and spermatocelectomy are routine scrotal surgeries. A significant number of the surgical specimens are sent for pathology analysis. However, to our knowledge no study has been done to examine outcomes and necessity, which results in significant potentially unnecessary costs to the patient and the health care system. We evaluated outcomes and surgical pathology analysis of hydroceles and spermatoceles.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Functional Magnetic Resonance Imaging during Urodynamic Testing Identifies Brain Structures Initiating Micturition

Normal voiding in neurologically intact patients is triggered by the release of tonic inhibition from suprapontine centers, allowing the pontine micturition center to trigger the voiding reflex. Supraspinal mechanisms of voluntary voiding in humans are just beginning to be described via functional neuroimaging. We further elucidated brain activity processes during voiding using functional magnetic resonance imaging in normal females to gain better understanding of normal voiding as well as changes that may occur in voiding dysfunction.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Survival of men with prostate cancer undergoing radical prostatectomy in Ontario

Radical prostatectomy is traditionally reserved for men with a life-expectancy of at least 10 years. Numerous studies have shown that survival estimates by physicians are inaccurate.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Obesity and Long-Term Survival after Radical Prostatectomy

Obesity is a modifiable risk factor associated with worse outcomes for many cancers, yet implications for prostate cancer are not well understood. Notably the impact of body mass index on long-term survival after treatment is unclear. We performed a retrospective cohort study on a large series of men who underwent radical prostatectomy to assess the impact of obesity on long-term biochemical recurrence-free survival, prostate cancer specific survival and overall survival.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Optimization of Prostate Biopsy: the Role of Magnetic Resonance Imaging Targeted Biopsy in Detection, Localization and Risk Assessment

Optimization of prostate biopsy requires addressing the shortcomings of standard systematic transrectal ultrasound guided biopsy, including false-negative rates, incorrect risk stratification, detection of clinically insignificant disease and the need for repeat biopsy. Magnetic resonance imaging is an evolving noninvasive imaging modality that increases the accurate localization of prostate cancer at the time of biopsy, and thereby enhances clinical risk assessment and improves the ability to appropriately counsel patients regarding therapy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Diffusion Tensor Magnetic Resonance Imaging and Fiber Tractography of the Sacral Plexus in Children with Spina Bifida

It is still largely unknown how neural tube defects in spina bifida affect the nerves at the level of the sacral plexus. Visualizing the sacral plexus in 3 dimensions could improve our anatomical understanding of neurological problems in patients with spina bifida. We investigated anatomical and microstructural properties of the sacral plexus of patients with spina bifida using diffusion tensor imaging and fiber tractography.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

GALNT4 Predicts Clinical Outcome in Patients with Clear Cell Renal Cell Carcinoma

We investigated the clinical significance of GALNT4 expression in patients with clear cell renal cell carcinoma.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Glans Preservation Contributes to Postsurgical Restoration of Male Sexual Function: A Multicenter Clinical Study of Glans-Preserving Surgery

We conducted this study to evaluate whether glans-preserving surgery (GPS) would be more helpful for patients to regain satisfactory sexual competency than conventional partial amputation after operation.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Tissue Engineering of the Bladder: Reality or Myth? A Systematic Review

We systematically reviewed preclinical studies in the literature to evaluate the potential of tissue engineering of the bladder. Study outcomes were compared to the available clinical evidence to assess the feasibility of tissue engineering for future clinical use.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

promoter methylation is associated with recurrence in early stage prostate cancer

Recurrent Prostate cancer remains a major problem, where staging, grading and prostate-specific antigen (PSA) level at the time of surgery are helpful, but still imperfect predictors for recurrence. For this reason, there is an imperative need of additional biomarkers that add to the prediction of the currently used prognostic factors.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Safety of the “Drain and Retain” Option for Defunctionalized Urologic Prosthetic Balloons and Reservoirs during Artificial Urinary Sphincter and Inflatable Penile Prosthesis Revision Surgery: 5-Year Experience

C. A. Cefalu, X. Deng, L. C. Zhao, J. F. Scott, S. Mehta and A. F. Morey

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Deep Lateral Transurethral Incisions for Recurrent Bladder Neck Contracture: Promising 5-Year Experience Using a Standardized Approach

D. Ramirez, L. C. Zhao, A. Bagrodia, J. F. Scott, S. J. Hudak and A. F. Morey

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Artificial Urinary Sphincter Revision: The Role of Ultrasound

B. M. Brucker, A. Demirtas, E. Fong, C. Kelly and V. W Nitti

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Unfavorable Outcomes of Laparoscopic Pyeloplasty Using Barbed Sutures: A Multi-Center Experience

E. Liatsikos, T. Knoll, I. Kyriazis, I. Georgiopoulos, P. Kallidonis, P. Honeck and J. U. Stolzenburg

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Management of Secondary Pelvi-Ureteric Junction Obstruction—A Comparison of Pyeloplasty and Endopyelotomy

M. Vannahme, S. Mathur, K. Davenport, A. G. Timoney and F. X. Keeley, Jr.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

High Prevalence of Screen Detected Prostate Cancer in West Africans: Implications for Racial Disparity of Prostate Cancer

To our knowledge the reasons for the high rates of prostate cancer in black American men are unknown. Genetic and lifestyle factors have been implicated. Better understanding of prostate cancer rates in West African men would help clarify why black American men have such high rates since the groups share genetic ancestry and yet have different lifestyles and screening practices. To estimate the prostate cancer burden in West African men we performed a population based screening study with biopsy confirmation in Ghana.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Is There a Role for Body Mass Index in the Assessment of Prostate Cancer Risk on Biopsy?

We examine the role of body mass index in the assessment of prostate cancer risk.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Quality of Life in Patients Treated for Penile Cancer

We assessed the impact of primary surgery, including penile sparing surgery vs (partial) penectomy and lymphadenectomy, on sexuality and health related quality of life.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Does Robotic Assistance Confer an Economic Benefit during Laparoscopic Radical Nephrectomy?

While robotic assisted radical nephrectomy is safe with outcomes and complication rates comparable to those of the pure laparoscopic approach, there is little evidence of an economic or clinical benefit.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Chronic Kidney Disease Due to Surgical Removal of Nephrons: Relative Rates of Progression and Survival

Chronic kidney disease is associated with a higher likelihood of progression to end stage renal disease and increased mortality rates. However, the etiology of nephron loss may modify the rate of chronic kidney disease progression and overall survival.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Clinical Validation of an Epigenetic Assay to Predict Negative Histopathological Results in Repeat Prostate Biopsies

The DOCUMENT multicenter trial in the United States validated the performance of an epigenetic test as an independent predictor of prostate cancer risk to guide decision making for repeat biopsy. Confirming an increased negative predictive value could help avoid unnecessary repeat biopsies.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Early Rehospitalization after Kidney Transplantation: Assessing Preventability and Prognosis

M. Harhay, E. Lin, A. Pai, M. O. Harhay, A. Huverserian, A. Mussell, P. Abt, M. Levine, R. Bloom, J. A. Shea, A. B. Troxel and P. P. Reese

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Smoking and the Risk of Mortality and Vascular and Respiratory Events in Patients Undergoing Major Surgery

K. M. Musallam, F. R. Rosendaal, G. Zaatari, A. Soweid, J. J. Hoballah, P. M. Sfeir, S. Zeineldine, H. M. Tamim, T. Richards, D. R. Spahn, L. A. Lotta, F. Peyvandi and F. R. Jamali

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: I COUGH: Reducing Postoperative Pulmonary Complications with a Multidisciplinary Patient Care Program

M. R. Cassidy, P. Rosenkranz, K. McCabe, J. E. Rosen and D. McAneny

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Decreasing Need for Artificial Urinary Sphincter Revision Surgery by Precise Cuff Sizing in Men with Spongiosal Atrophy

Many patients with persistent incontinence after an artificial urinary sphincter procedure gain improved continence after cuff downsizing. In 2010 a new, smaller (3.5 cm) artificial urinary sphincter cuff was introduced. We hypothesized that men with spongiosal atrophy previously treated with a 4.0 cm cuff would now show a decreased rate of revision surgery due to more accurate cuff sizing.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Inhibition of Peripheral FAAH Depresses Activities of Bladder Mechanosensitive Nerve Fibers of the Rat

FAAH degrades endocannabinoids and fatty acid amides. FAAH inhibition reduces micturition frequency and counteracts bladder overactivity in rats. We studied the effects of the peripherally active selective FAAH inhibitor URB937, and the CB1 and CB2 receptor antagonists rimonabant and SR144528, respectively, on single unit afferent activity of primary bladder afferents in rats.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Effect of Sildenafil and Udenafil on Testicular Damage Following Ischemia-Reperfusion Injury in Rats

Ischemia-reperfusion injury can cause testicular damage and phosphodiesterase inhibitors are reported to regulate antioxidant activity. We investigated the prevention of ipsilateral and contralateral testicular damage using 2 phosphodiesterase inhibitors after testicular detorsion in rats.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Regular Transition Zone Biopsy During Active Surveillance for Prostate Cancer May Improve Detection of Pathological Progression

We investigated the frequency of cancer and pathological progression in transition zone biopsies in men undergoing multiple rebiopsies while on active surveillance.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Management of Urinary Fistulas Due to Midurethral Sling Surgery

We report our experience with the diagnosis and treatment of women with urinary fistula after mid urethral sling surgery.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Outcome of Transvaginal Mesh and Tape Removed for Pain Only

Because there is reluctance to operate for pain, we evaluated midterm outcomes of vaginal mesh and synthetic suburethral tape removed for pain as the only indication.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Intraurethral Injection of Autologous Minced Skeletal Muscle: A Simple Surgical Treatment for Stress Urinary Incontinence

Intraurethral injection of in vitro expanded autologous skeletal muscle derived cells is a new regenerative therapy for stress urinary incontinence. We examined the efficacy and safety of a simpler alternative strategy using freshly harvested, minced autologous skeletal muscle tissue with its inherent content of regenerative cells.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Use of Nephron Sparing Surgery and Impact on Survival in Children with Wilms Tumor: A SEER Analysis

Nephron sparing surgery is the standard of care for many adults with renal tumors and has been described in some children with Wilms tumor. However, beyond case series the data concerning nephron sparing surgery application and outcomes in patients with Wilms tumor are scarce. We examined nephron sparing surgery outcomes and factors associated with its application in children with Wilms tumor.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Epididymitis: A 21-Year Retrospective Review of Boys Presenting to an Outpatient Urology Clinic

We describe patient characteristics and age distribution of epididymitis in an outpatient pediatric urology referral practice during a 21-year period.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reassessment of Prognostic Heterogeneity of pT3 Renal Pelvic Urothelial Carcinoma: Analysis in Terms of 3 Proposed pT3 Subclassification Systems

We determined whether the 3 pT3 subclassification systems reported by the Asan, Cornell and Nagoya groups provide an accurate estimation of patient prognosis. We also determined which subclassification is most predictive of the heterogeneous oncological outcomes of pT3 renal pelvic urothelial carcinoma.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Pneumoperitoneum in the Presence of Acute and Chronic Kidney Injury: An Experimental Model in Rats

There is evidence that pneumoperitoneum induces transient changes in renal function in healthy individuals. Its effect on malfunctioning kidneys is not well known. We investigated effects caused by pneumoperitoneum in animals with impaired renal function.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

How Should Continence and Incontinence after Radical Prostatectomy Be Evaluated? A Prospective Study of Patient Ratings and Changes with Time

We examined prevalence rates, and changes in continence and incontinence before and after radical prostatectomy for prostate cancer by comparing different definitions. We also studied the descriptive validity of the grading system of Ellison et al for post-prostatectomy incontinence and baseline predictors of post-prostatectomy incontinence at 12 months.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Level III-IV Inferior Vena Caval Thrombectomy Without Cardiopulmonary Bypass: Long-Term Experience with Intrapericardial Control

Inferior vena cava tumor thrombectomy requires experienced surgical teams due to complex hemodynamic considerations. The teams often use vascular bypass techniques that introduce additional risk. Inferior vena caval control in the pericardium obviates the need for cardiopulmonary bypass. We reviewed our experience with intrapericardial control during inferior vena caval tumor thrombectomy to evaluate perioperative outcomes and determine factors associated with overall survival.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Oncologic Outcomes Following Surgical Resection of Renal Cell Carcinoma with Inferior Vena Caval Thrombus Extending Above the Hepatic Veins: A Contemporary Multicenter Cohort

Suprahepatic inferior vena caval tumor thrombus in renal cell carcinoma cases has historically portended a poor prognosis. With advances in perioperative treatment of patients with high level thrombus contemporary outcomes are hypothesized to be improved. We evaluated long-term oncologic outcomes of contemporary surgical treatment of patients with renal cell carcinoma in whom level III-IV inferior vena caval thrombus was managed at high volume centers.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Resource Utilization and Costs Associated with the Diagnostic Evaluation of Nonrefluxing Primary Hydronephrosis in Infants

Long-term evaluation of postnatal nonrefluxing primary hydronephrosis presents a dilemma for urologists since most cases resolve without surgery. We report longitudinal resource utilization and costs associated with diagnostic evaluation of infants with isolated primary nonrefluxing hydronephrosis to determine the costs associated with diagnosing a surgical case, and we assess the implications using a cost-consequences analysis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Efficacy and Safety of Polyacrylamide Hydrogel for the Treatment of Female Stress Incontinence: A Randomized, Prospective, Multicenter North American Study

Bulkamid® is a new polyacrylamide hydrogel bulking agent for stress urinary incontinence that is injected in the urethral submucosa using a specifically designed device. We evaluated the safety and efficacy of Bulkamid vs Contigen® collagen gel for stress urinary incontinence or stress predominant mixed urinary incontinence.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

von Hippel-Lindau Exonic Methylation Analysis Using MALDI-TOF Mass Spectrometry

Aberrant promoter methylation turns off gene expression and is involved in human malignancy. Studies show that first exon methylation has a tighter association with gene silencing compared to promoter methylation or gene mutation. However, to our knowledge the clinical importance of exonic methylation in renal cell carcinoma is unknown. We analyzed renal cell carcinoma for VHL gene exonic methylation using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Visceral Obesity in Predicting Oncologic Outcomes of Localized Renal Cell Carcinoma

We investigate the clinicopathological features and prognostic significance of visceral obesity in patients with localized renal cell carcinoma.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prospective Measurement of Urinary Microalbumin in Living Kidney Donor Nephrectomy: Toward Understanding the Renal Functional Recovery Period

We determined the clinical implications of perioperative urinary microalbumin excretion in relation to renal function after living donor nephrectomy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Total Phallic Reconstruction Using Radial Artery Based Forearm Free Flap Phalloplasty in Patients with Epispadias-Exstrophy Complex

We report our experience with total phallic construction using the radial artery forearm free flap in patients with bladder/cloacal exstrophy and micropenis-epispadias complex.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Limited Field Noncontrast Computerized Tomography for Followup of Ureteral Stones: Initial Results

Due to high specificity and sensitivity noncontrast computerized tomography is increasingly used to diagnose and follow patients with ureteral stones. We evaluated the feasibility of limited field noncontrast computerized tomography to follow patients with ureteral stones.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Murine Bladder Imaging by 2-Photon Microscopy: An Experimental Study of Morphology

We developed 2-photon laser scanning microscopy analysis of the native murine bladder.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Low Testosterone at Time of Transplantation Is Independently Associated with Poor Patient and Graft Survival in Male Renal Transplant Recipients

Low testosterone is common in men with renal disease and it increases the risk of death in those on dialysis. We studied serum testosterone at transplantation and correlated it with patient and graft outcomes.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Combined Chemohyperthermia: 10-Year Single Center Experience in 160 Patients with Nonmuscle Invasive Bladder Cancer

Nonmuscle invasive bladder cancer is characterized by a high recurrence rate. New adjuvant treatments are needed to decrease this high number of recurrences. We present the results of more than 10 years of experience with chemohyperthermia in patients with nonmuscle invasive bladder cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Evaluation of Prenatal Hydronephrosis: Novel Criteria for Predicting Vesicoureteral Reflux on Ultrasonography

Radiographic evaluation for prenatal hydronephrosis often includes voiding cystourethrography to ascertain whether vesicoureteral reflux is present. We sought to determine whether use of voiding cystourethrography could be limited to those patients at greatest risk for vesicoureteral reflux. We hypothesized that vesicoureteral reflux could be predicted by findings on renal/bladder ultrasonography of hydroureter, renal dysmorphia and/or duplication.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Evaluation of a Mobile Voiding Diary for Pediatric Patients with Voiding Dysfunction: A Prospective Comparative Study

One potential strategy for improving voiding diary completion rates and data quality is use of a mobile electronic format. We evaluated the acceptability and feasibility of mobile voiding diaries for patients with nonneurogenic lower urinary tract dysfunction, and compared mobile and paper voiding diaries.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Impact of Bladder Cancer on Health Related Quality of Life in 1,476 Older Americans: A Cross-Sectional Study

The impact of bladder cancer diagnosis on health related quality of life is poorly understood. We compared health related quality of life measures in patients before and after bladder cancer diagnosis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prognostic Significance of Biallelic Loss of in Clear Cell Renal Cell Carcinoma

We investigated the clinical implications of biallelic loss of PTEN in clear cell renal cell carcinoma and whether PTEN biallelic loss would induce p53 dependent cellular senescence.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Impact of Resident Involvement on Urological Surgery Outcomes: An Analysis of 40,000 Patients from the ACS NSQIP Database

In addition to excellent patient care, the focus of academic medicine has traditionally been resident training. The changing landscape of health care has placed increased focus on objective outcomes. As a result, the surgical training process has come under scrutiny for its influence on patient care. We elucidated the effect of resident involvement on patient outcomes.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Systematic Review of the Efficacy and Safety of Desmopressin for Nocturia in Adults

We systematically reviewed desmopressin as treatment for nocturia in generally healthy adults with a focus on benefits and harms.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

15-Year Cause Specific and All-Cause Survival Following Brachytherapy for Prostate Cancer: Negative Impact of Long-Term Hormonal Therapy

We analyzed factors influencing 15-year cause specific and all-cause survival in men treated with prostate brachytherapy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Alterations in Resting State Oscillations and Connectivity in Sensory and Motor Networks in Women with Interstitial Cystitis/Painful Bladder Syndrome

The pathophysiology of interstitial cystitis/painful bladder syndrome remains incompletely understood but is thought to involve central disturbance in the processing of pain and viscerosensory signals. We identified differences in brain activity and connectivity between female patients with interstitial cystitis/painful bladder syndrome and healthy controls to advance clinical phenotyping and treatment efforts for interstitial cystitis/painful bladder syndrome.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Immunomodulatory Intervention with Interferon-γ in Escherichia coli Pyelonephritis

We investigated the efficacy of recombinant human interferon-γ in experimental pyelonephritis due to Escherichia coli.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Adherence to Performance Measures and Outcomes among Men Treated for Prostate Cancer

We assessed the relationship between health care system performance on nationally endorsed prostate cancer quality of care measures and prostate cancer treatment outcomes.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Defining and Treating the Spectrum of Intermediate Risk Nonmuscle Invasive Bladder Cancer

Low, intermediate and high risk categories have been defined to help guide the treatment of patients with nonmuscle invasive bladder cancer (Ta, T1, CIS). However, while low and high risk disease has been well classified, the intermediate risk category has traditionally comprised a heterogeneous group that does not fit into either of these categories. As a result, many urologists remain uncertain about the categorization of patients as intermediate risk as well as the selection of the most appropriate therapeutic option for this patient population.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Tissue Engineered Cystoplasty Augmentation for Treatment of Neurogenic Bladder Using Small Intestinal Submucosa: An Exploratory Study

Bladder augmentation with enterocystoplasty is the gold standard therapy for neurogenic bladder. The presence of gastrointestinal segments in the urinary tract has been associated with many complications. We investigated an alternative approach using small intestinal submucosa as scaffold for reconstruction.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Lichen Sclerosus and Isolated Bulbar Urethral Stricture Disease

Lichen sclerosus is a chronic inflammatory genital skin condition that can cause destructive urethral scarring. To our knowledge no prior study has described lichen sclerosus in isolated bulbar urethral stricture segments without progressive disease originating from the penile urethra. We report the incidence of lichen sclerosus in isolated bulbar urethral stricture segments.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Testosterone Supplementation Versus Clomiphene Citrate for Hypogonadism: An Age Matched Comparison of Satisfaction and Efficacy

We compared satisfaction and treatment efficacy in men with symptomatic hypogonadism who received clomiphene citrate or testosterone supplementation therapy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Procedures Needed to Maintain Functionality of Adult Continent Catheterizable Channels: A Comparison of Continent Cutaneous Ileal Cecocystoplasty with Tunneled Catheterizable Channels

We compared the outcomes of various adult continent catheterizable channels in a multi-institutional setting.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Poorly Functioning Kidneys Recover from Ischemia after Partial Nephrectomy as Well as Strongly Functioning Kidneys

Poorly functioning kidneys may not recover from ischemia as well as strongly functioning kidneys. This could impact surgical approaches to partial nephrectomy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Natural History of Clinically Complete Responders to Neoadjuvant Chemotherapy for Urothelial Carcinoma of the Bladder

We describe the clinical course of patients who achieved cT0 status after neoadjuvant chemotherapy for muscle invasive bladder cancer. There is no established treatment paradigm for these patients.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Shock Wave Lithotripsy Targeting of the Kidney and Pancreas Does Not Increase the Severity of Metabolic Syndrome in a Porcine Model

We determined whether shock wave lithotripsy of the kidney of pigs with metabolic syndrome would worsen glucose tolerance or increase the risk of diabetes mellitus.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Correlation of Patient Perception of Pad Use with Objective Degree of Incontinence Measured by Pad Test in Men with Post-Prostatectomy Incontinence: The SUFU Pad Test Study

Many investigators have used the number of pads to determine the severity of post-prostatectomy incontinence and yet the accuracy of this tool remains unproven. We determined whether the patient perception of pad use and urine loss reflects actual urine loss. We also identified a quality of life measure that distinguishes patients by severity of incontinence.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Partial Bladder Outlet Obstruction in Mice May Cause E-Cadherin Repression through Hypoxia Induced Pathway

Posterior urethral valves are the most common cause of partial bladder outlet obstruction in the pediatric population. Posterior urethral valves is a devastating clinical problem that ultimately results in urinary incontinence, neurogenic bladder and renal impairment. Despite improvements in medical and surgical management at least a third of patients with this condition progress to end stage renal disease and half will have problems with urinary incontinence. To achieve better understanding of the mechanism associated with clinical events we generated partial bladder outlet obstruction in male mice.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Risk Factors for 30-Day Perioperative Complications after Le Fort Colpocleisis

We identified rates of and risk factors for complications after colpocleisis using the American College of Surgeons NSQIP® database.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Diffusion-Weighted Magnetic Resonance Imaging Detects Significant Prostate Cancer with High Probability

We prospectively assessed the diagnostic accuracy of diffusion-weighted magnetic resonance imaging for detecting significant prostate cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Growth Kinetics and Short-Term Outcomes of cT1b and cT2 Renal Masses under Active Surveillance

Compared to T1a lesions the natural history of untreated renal masses larger than 4 cm is poorly understood. We assessed the growth kinetics and outcomes of cT1b/T2 cortical renal tumors managed by an initial period of active surveillance. We compared these cases to those treated with definitive delayed intervention.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Voltage Dependence of Slow Wave Frequency in the Guinea Pig Prostate

Spontaneous phasic contractions of the guinea pig prostate stroma result from the generation of slow waves, which appear to primarily rely on spontaneous Ca2+ release from the endoplasmic/sarcoplasmic reticulum and subsequent opening of Ca2+ activated chloride channels. We investigated voltage dependent mechanisms in the regulation of slow wave frequency.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Targeted Focal Therapy for the Management of Organ Confined Prostate Cancer

Patients currently diagnosed with low risk prostate cancer are often overtreated and experience complications, resulting in detriment to quality of life. Targeted focal therapy is a minimally invasive procedure designed to ablate tumor foci while minimizing collateral damage to maintain quality of life.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Relative Value of Race, Family History and Prostate Specific Antigen as Indications for Early Initiation of Prostate Cancer Screening

Many guidelines suggest earlier screening for prostate cancer in men at high risk, with risk defined in terms of race and family history. Recent evidence suggests that baseline prostate specific antigen is strongly predictive of the long-term risk of aggressive prostate cancer. We compared the usefulness of risk stratifying early screening by race, family history and prostate specific antigen at age 45 years.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Infectious Outcomes of Nephrostomy Drainage before Percutaneous Nephrolithotomy Compared to Concurrent Access

We hypothesized that establishing percutaneous nephrostomy drainage and treating with renal urine culture specific antibiotics would lead to a decreased sepsis rate in patients at increased risk for infection. We analyzed the experience of a single surgeon with sepsis after percutaneous nephrolithotomy following prior nephrostomy drainage compared to percutaneous nephrolithotomy with concurrent percutaneous renal collecting system access.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Microvascular Invasion of Testicular Nonseminomatous Germ Cell Tumors: Implications of Separate Evaluation of Lymphatic and Blood Vessels

We separately evaluated the lymphatic and blood vascular systems to assess the diagnostic accuracy of microvascular invasion and identify predictive markers for occult metastasis of testicular nonseminomatous germ cell tumors.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Feasibility and Oncologic Control after Percutaneous Image Guided Ablation of Metastatic Renal Cell Carcinoma

We assessed the safety, local control and oncologic efficacy of percutaneous ablation in the treatment of metastatic renal cell carcinoma.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Impact of Hemiscrotectomy on Outcome of Patients with Embryonal Paratesticular Rhabdomyosarcoma: Results from the Cooperative Soft Tissue Sarcoma Group Studies CWS-86, 91, 96 and 2002P

Children with paratesticular rhabdomyosarcoma have a favorable prognosis. Surgical treatment problems include inadequate primary transscrotal approaches, incomplete tumor resections and the need for secondary hemiscrotectomy. We evaluated the need for hemiscrotectomy regarding local relapse and outcome.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Pseudospongioplasty Using Periurethral Vascularized Tissue to Support Ventral Buccal Mucosa Grafts in the Distal Urethra

For ventral buccal mucosa graft onlay during bulbar urethroplasty, spongioplasty with advancement and closure of the corpus spongiosum is ordinarily performed to stabilize the graft. In the pendulous and distal bulbar urethra the spongiosum is often too thin to allow complete graft coverage. We describe the results of what to our knowledge is a novel technique for ventral graft coverage using periurethral vascularized tissue. We compared these results to those of conventional spongioplasty.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Validation of Team Performance Assessment of Multidisciplinary Tumor Boards

We construct validated the instrument to evaluate assessor learning curves and the feasibility and interrater reliability of MTB-MODe for assessing the decision making process using video recorded multidisciplinary tumor board meetings.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Predictors of Unfavorable Disease after Radical Prostatectomy in Patients at Low Risk by D'Amico Criteria: Role of Multiparametric Magnetic Resonance Imaging

We identified risk factors predicting unfavorable pathological outcomes after radical prostatectomy in patients with low risk prostate cancer. We also evaluated the role of magnetic resonance imaging.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Clinical Outcome of Patients with T1 Micropapillary Urothelial Carcinoma of the Bladder

We report cancer specific outcomes of micropapillary nonmuscle invasive bladder cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Salvage Surgical Resection for Isolated Locally Recurrent Inguinal Lymph Node Metastasis of Penile Cancer: International Study Collaboration

We assessed the merit of performing salvage inguinal lymph node dissection in those infrequent cases of penile cancer with locally recurrent inguinal lymph node metastases in the absence of other suspected sites of disease.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Artificial Urinary Sphincter AMS 800™ in Males—Can We Explain Residual Leaks When Sitting?

Some patients fitted with an AMS 800™ type artificial urinary sphincter report urinary leaks in the sitting position whose mechanism remains unclear. In this experimental study we explain these residual leaks by characterizing fluid transfer and pressure variations in the device during cuff compression.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Cross-Sectional Study of Determinants of Upper and Lower Urinary Tract Outcomes in Adults with Spinal Dysraphism—New Recommendations for Urodynamic Followup Guidelines?

Although annual urodynamic study is currently recommended for all adults with spinal dysraphism, this followup might be overly intensive. Therefore, in this cross-sectional study we examine which determinants of upper and lower urinary tract outcomes are associated with relevant urodynamic findings.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prophylactic Sildenafil Citrate Improves Select Aspects of Sexual Function in Men Treated with Radiotherapy for Prostate Cancer

We studied adjuvant daily sildenafil citrate during and after radiotherapy for prostate cancer for erectile function preservation.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Use and Outcomes of Extended Antibiotic Prophylaxis in Urological Cancer Surgery

Although perioperative antibiotic prophylaxis prevents postoperative infectious complications, national guidelines recommend cessation of antibiotics within 24 hours after the procedure. Extended antibiotic prophylaxis beyond 24 hours may contribute to hospital acquired infections such as Clostridium difficile colitis. We evaluated practice patterns of antibiotic prophylaxis in genitourinary cancer surgery and assessed the impact of antibiotic prophylaxis on hospital acquired C. difficile infections.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Predicting Risk of Erectile Dysfunction after Pelvic Fracture Urethral Injury in Children

We sought to determine the incidence of erectile dysfunction following pelvic fracture urethral injuries in children, and to identify the related causes and risk factors.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

An Intricate Network of Conserved DNA Upstream Motifs and Associated Transcription Factors Regulate the Expression of Uromodulin Gene

Uromodulin is a kidney specific glycoprotein whose expression can modulate kidney homeostasis. However, the set of sequence specific transcription factors that regulate the uromodulin gene UMOD and their upstream binding locations are not well characterized. We built a high resolution map of its transcriptional regulation.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Importance of Surgeon Characteristics on Impacting Oncologic Outcomes for Patients Undergoing Radical Cystectomy

Given that the urologist has a major influence on outcomes of radical cystectomy, it is of interest to patients, trainees, urologists and administrators to understand the provider characteristics associated with favorable outcomes. Therefore, we assessed associations between various surgeon characteristics and long-term oncologic outcomes for patients undergoing radical cystectomy for bladder cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Venous Thromboembolism after Urological Surgery

We determined the rates of deep venous thromboembolism and pulmonary embolism after common urological procedures in the United States.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Overactive Bladder Changes with Time: A 5-Year Longitudinal Followup of Changes in Overactive Bladder Symptoms, Urodynamic Studies and Urinary Nerve Growth Factor Levels

We compared clinical symptoms, urodynamic diagnoses and urinary nerve growth factor levels at baseline and 5 years later in patients with overactive bladder.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Modified Gleason Grade of Prostatic Adenocarcinomas Detected in the PLCO Cancer Screening Trial

We determined the modified Gleason grade of prostatic adenocarcinomas detected in PLCO to assess grade distribution and compare modified Gleason grades of cancer detected in the intervention arm (organized annual screening) vs the control arm (opportunistic screening).

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Port Site Metastasis after Surgery for Renal Cell Carcinoma: Harbinger of Future Metastasis

Port site metastasis is a rare occurrence after minimally invasive treatment for renal cell carcinoma. However, its prognostic implications are unclear because reports in the literature are heterogeneous in detail and followup. We clarify the significance of port site metastasis in cancer specific survival and broaden our understanding of this phenomenon.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Variation in Prostate Cancer Detection Rates in a Statewide Quality Improvement Collaborative

There remains significant controversy surrounding the optimal criteria for recommending prostate biopsy. To examine this issue further urologists in MUSIC assessed statewide prostate biopsy practice patterns and variation in prostate cancer detection.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Functional Multiparametric Magnetic Resonance Imaging of the Kidneys Using Blood Oxygen Level Dependent and Diffusion-Weighted Sequences

Little data are available on noninvasive magnetic resonance imaging based assessment of renal function during upper urinary tract obstruction. We determined whether functional multiparametric kidney magnetic resonance imaging could monitor the treatment response in cases of acute unilateral upper urinary tract obstruction.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Autologous Muscle Derived Cells for Treatment of Stress Urinary Incontinence in Women

We assess the 12-month safety and potential efficacy of autologous muscle derived cells for urinary sphincter repair (Cook MyoSite Incorporated, Pittsburgh, Pennsylvania) in women with stress urinary incontinence.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Age and Baseline Quality of Life at Radical Prostatectomy—Who Has the Most to Lose?

Although younger men have better health related quality of life scores after radical prostatectomy, many have higher baseline function with more to lose than older men. We examined the impact of age on sexual and urinary function and bother during the first 2 years after radical prostatectomy.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Elucidation of Distinctive Genomic DNA Structures in Patients with 46,XX Testicular Disorders of Sex Development Using Genome Wide Analyses

Although several genes, including the SRY gene, are involved in testicular differentiation, the entire mechanism of this differentiation remains unclear. We performed genome wide analysis in patients with 46,XX testicular disorders of sex development to comprehensively elucidate the mechanisms of testicular differentiation.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Dramatic Increase in Social Media in Urology

Social media are established tools for rapid information dissemination to a broad audience. A major use has been the compilation of conference specific messaging known as tweets via preselected hashtags on Twitter. We analyzed Twitter use between consecutive years at the AUA (American Urological Association) and CUA (Canadian Urological Association) annual meetings.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

shRNA Constructs Targeting IGFBP-3 Alleviate Age Related Erectile Dysfunction in the Rat

We investigated whether injecting shRNA constructs targeting IGFBP-3 in the penis of old rats would improve erectile function.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Timing and Predictors for Urinary Drainage in Children with Expectantly Managed Grade IV Renal Trauma

We determined which children sustaining blunt grade IV renal trauma are at greatest risk for failing nonoperative management and in what time frame they will likely present.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Urologists’ Use of Intensity-Modulated Radiation Therapy for Prostate Cancer

J. M. Mitchell

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Long-Term Followup and Deterioration Rate of Anterior Substitution Urethroplasty

We investigated deterioration of the success rate of penile and bulbar substitution urethroplasty.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Bladder Cancer Exosomes Contain EDIL-3/Del1 and Facilitate Cancer Progression

High grade bladder cancer is an extremely aggressive malignancy associated with high rates of morbidity and mortality. Understanding how exosomes may affect bladder cancer progression could reveal novel therapeutic targets.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Surgical Outcomes in the Management of Isolated Nodal Recurrences: A Multicenter, International Retrospective Cohort

We report a multicenter international cohort representing what is to our knowledge the largest surgical experience with managing isolated retroperitoneal nodal recurrence of renal cell carcinoma, a unique subset of locoregional disease, yet to be described in detail.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

30-Day Hospital Readmission after Robotic Partial Nephrectomy—Are We Prepared for Medicare Readmission Reduction Program?

After CMS introduced the concept of the Hospital Readmissions Reduction Program, hospitals and health care centers became financially penalized for exceeding specific readmission rates.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Immediate Urethral Repair during Explantation Prevents Stricture Formation after Artificial Urinary Sphincter Cuff Erosion

We compare stricture outcomes in patients with artificial urinary sphincter cuff erosion managed with and without synchronous urethral repair.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Targeted Prostate Biopsy to Select Men for Active Surveillance: Do the Epstein Criteria Still Apply?

Established in 1994, the Epstein histological criteria (Gleason score 6 or less, 2 or fewer cores positive and 50% or less of any core) have been widely used to select men for active surveillance. However, with the advent of targeted biopsy, which may be more accurate than conventional biopsy, we reevaluated the likelihood of reclassification upon confirmatory rebiopsy using multiparametric magnetic resonance imaging-ultrasound fusion.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prognostic Utility of the Cell Cycle Progression Score Generated from Biopsy in Men Treated with Prostatectomy

The cell cycle progression score is associated with prostate cancer outcomes in various clinical settings. However, previous studies of men treated with radical prostatectomy evaluated cell cycle progression scores generated from resected tumor tissue. We evaluated the prognostic usefulness of the score derived from biopsy specimens in men treated with radical prostatectomy.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Down-Regulation of UNC5D in Bladder Cancer: UNC5D as a Possible Mediator of Cisplatin Induced Apoptosis in Bladder Cancer Cells

Identifying potential targets would improve therapeutic planning and disease management. Therefore, we investigated whether the novel identified dependence receptor UNC5D acts as a tumor suppressor in bladder malignancies.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Identification of Spermatogenesis in a Rat Sertoli-Cell Only Model Using Raman Spectroscopy: A Feasibility Study

We determined whether Raman spectroscopy could identify spermatogenesis in a Sertoli-cell only rat model.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Clinical Outcomes of Local and Metastatic Testicular Sex Cord-Stromal Tumors

We evaluated pathological variables of testicular sex cord-stromal tumors, management options and clinical outcomes.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Surgical Outcomes and Cultural Perceptions in International Hypospadias Care

This study was designed to assess perceptions of untreated hypospadias and quality of life in culturally disparate low or middle income countries, to highlight the demographic and care differences of patient groups treated for hypospadias in the surgical workshop context, and to evaluate the long-term outcomes achieved by these workshop groups.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Association of CXCR3 and Renal Cell Carcinoma Metastasis

Renal cell carcinoma expresses CXCR3 but the function of CXCR3 in renal cell carcinoma has not been clarified. We explored the function of CXCR3 in renal cell carcinoma and investigated CXCR3 regulating factors.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Statin Drug Use is Not Associated with Prostate Cancer Risk in Men Who are Regularly Screened

Prospective cohort studies support the hypothesis that statin drug users have a lower risk of aggressive prostate cancer. Whether statin drug use influences the risk of screen detected disease is less clear, possibly because of complex detection biases. Thus, we investigated this association in a setting in which men had low baseline serum prostate specific antigen concentration and were screened annually.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Does Structured Withdrawal of Desmopressin Improve Relapse Rates in Patients with Monosymptomatic Enuresis?

Relapse after cessation of desmopressin is an important problem in treating patients with enuresis. Structured withdrawal of desmopressin tablets has been shown to decrease relapse rates. However, scientific data are lacking on the structured withdrawal of the fast melting oral formulation of desmopressin. We compared relapse rates of structured withdrawal using placebo and direct cessation in a population of patients with enuresis who were desmopressin responders.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Effect of Aging on Storage and Voiding Function in Women with Stress Predominant Urinary Incontinence

We investigated age related changes in urodynamic parameters in 2 large cohorts of women planning stress urinary incontinence surgery.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Tamsulosin and Spontaneous Passage of Ureteral Stones in Children: A Multi-Institutional Cohort Study

Tamsulosin is associated with increased passage of ureteral stones in adults but its effectiveness in children is uncertain. We determined the association between tamsulosin and the spontaneous passage of ureteral stones in children.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Validity and Reliability of the Neurogenic Bladder Symptom Score

The neurogenic bladder symptom score is a tool to measure urinary symptoms and consequences in patients with acquired or congenital neurogenic bladder. We describe score validity and reliability.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

NGAL Can Alternately Mediate Sunitinib Resistance in Renal Cell Carcinoma

Serum NGAL is highly expressed in patients with advanced renal cancer treated with sunitinib. We investigated the role of NGAL in sunitinib resistance in renal cell carcinoma to identify potential tactics to overcome it.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comprehensive Geriatric Assessment Can Predict Postoperative Morbidity and Mortality in Elderly Patients Undergoing Elective Surgery

K. I. Kim, K. H. Park, K. H. Koo, H. S. Han and C. H. Kim

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Renal Transplantation after Ex Vivo Normothermic Perfusion: The First Clinical Study

S. A. Hosgood

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Quantification of the Early Risk of Death in Elderly Kidney Transplant Recipients

J. S. Gill, E. Schaeffner, S. Chadban, J. Dong, C. Rose, O. Johnston and J. Gill

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Infection and Inflammation of the Genitourinary Tract

Y. Madani and B. Mann

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Combined ciprofloxacin and amikacin prophylaxis in the prevention of septicaemia after transrectal ultrasound guided biopsy of the prostate

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Purely Transvaginal/Perineal Management of Complications From Commerical Prolapse Kits Using a New Prostheses/Grafts Complication Classification System

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Response to Letter to the Editor

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Sleep Analysis of Patients with Nocturia and Benign Prostatic Obstruction

K. Bal, S. Ayik, Y. Issi, A. Bolukbasi and G. Akhan

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Involvement of Estrogen Receptors in Prostatic Diseases

H. Kawashima and T. Nakatani

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Perioperative outcomes and Oncologic Efficacy from a Pilot Prospective Randomized Clinical Trial of Open Versus Robotic Assisted Radical Cystectomy

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

In Vivo Evaluation of the Third Generation Biodegradable Stent: A Novel Approach to Avoiding the Forgotten Stent Syndrome

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Urodynamis Testing- Is it a Useful Tool in the Management of Children with Cutaneous Stigmata of Occult Spinal Dysraphism?

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Response to Letter to the Editor

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Ureteronenteric Anastomotic Strictures After Radical Cystectomy - Does Operative Approach Matter?

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply to Michael A. Gorin, Arthur I. Sagalowsky and Mark S. Soloway's Letter to the Editor re: S. Picozzi, C. Ricci, M. Gaeta et al. Upper urinary tract recurrence following radical cystectomy for bladder cancer: a meta-analysis on 13,185 patients. J Urol 2012; 188: 2046–54.

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply to Letter to the Editor

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Limitations of Preoperative Biopsy in Patients with Metastatic Renal Cell Carcinoma: Comparison to Surgical Pathology in 405 Cases

To evaluate the ability of preoperative biopsy to identify high-risk pathological features by comparing pathology from preoperative metastatic site and primary tumour biopsies with nephrectomy pathology in patients with metastatic renal cell carcinoma (mRCC).

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Response to "Letter to the Editor"

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Diagnostic Potential of Urinary <alpha>1-Antitrypsin and Apolipoprotein E in the Detection of Bladder Cancer

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Ameliorative Effects of Stinging Nettle (Urtica dioica) on Testosterone-Induced Prostatic Hyperplasia in Rats

A. Nahata and V. K. Dixit

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Persistence of Urgency and Urge Urinary Incontinence in Women with Mixed Urinary Symptoms After Midurethral Slings: A Multivariate Analysis

J. K. Lee, P. L. Dwyer, A. Rosamilia, Y. N. Lim, A. Polyakov and K. Stav

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Managing a Pessary Business

K. O'Dell, L. S. Wooldridge and S. Atnip

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Pessary Care: Follow up and Management of Complications

K. O'Dell and S. Atnip

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Loss of the Urothelial Differentiation Marker FOXA1 is Associated with High Grade, Late Stage Bladder Cancer and Increased Tumor Proliferation

Approximately 50% of patients with muscle-invasive bladder cancer (MIBC) develop metastatic disease, which is almost invariably lethal. However, our understanding of pathways that drive aggressive behavior of MIBC is incomplete. Members of the FOXA subfamily of transcription factors are implicated in normal urogenital development and urologic malignancies. FOXA proteins are implicated in normal urothelial differentiation, but their role in bladder cancer is unknown. We examined FOXA expression in commonly used in vitro models of bladder cancer and in human bladder cancer specimens, and used a novel in vivo tissue recombination system to determine the functional significance of FOXA1 expression in bladder cancer.

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prostatic Fibrosis Is Associated With Lower Urinary Tract Symptoms

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Post-Implantation Alterations of Polypropylene in the Human

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Post-Implantation Alterations of Polypropylene in the Human

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

RE: Long-Term Infection Outcomes of 3-Piece Antibiotic Impregnated Penile Prostheses Used in Replacement Implant Surgery [Letter to the Editor JU-12-1703]

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Response to letter to Editor from Lawrence Klotz re my Editorial Comment on Focal Therapy for Localised Unifocal and Multifocal Prostate Cancer: A Prospective Development Study

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Coated Implants and “No Touch” Surgical Technique Decreases Risk of Infection in Inflatable Penile Prosthesis Implantation to 0.46%

J. F. Eid, S. K. Wilson, M. Cleves and E. A. Salem

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Undescended Testis Histology Correlation with Adult Hormone Levels and Semen Analysis

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Response to Comments: Diagnostic Radiation Exposure Risk in A Contemporary Cohort of Male Patients with Germ Cell Tumor

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Comparative Effectiveness for Survival and Renal Function of Partial and Radical Nephrectomy for Localized Renal Tumors: A Systematic Review and Meta-Analysis

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply By Authors: Snodgraft Technıque In The Treatment Of Prımary Dıstal Hypospadıas Repaır: Pushıng The Envelope

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Semen Quality in Men Who Sustained a Spinal Cord Injury During the Prepubertal Period

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Information for Authors

The Journal of Urology® contains 4 sections: Adult Urology, Pediatric Urology, Investigative Urology and Urological Survey. Rapid Communications are welcomed. The Adult and Pediatric Urology Sections (original articles) usually do not publish laboratory animal studies. The Investigative Urology Section (research articles) does not publish clinically oriented articles, and does not require prior approval for Review Articles. Unsolicited material is not accepted for Urological Survey.

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Board

The Journal of Urology 192, 2 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Dr Alex Lesani, da vinci robotic surgeon in Las Vegas

6-17-2008.
Dr Lesani performs the first robotic surgery for the removal of kidney tumors in Las Vegas.

11-13-2009. 
Dr Lesani performs a laparoscopic removal of a kidney through a single umbilical incision; the first performed in State of Nevada.