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Prostate Cancer

Minimally invasive surgical options provide a better patient experience through a number of benefits:

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Fax:         702 223 4799
Urology is the surgical specialty concerned with correcting abnormalities of the genitourinary system in both men and women. A urologist may use medical treatment or resort to surgery to correct these abnormalities. Surgery is often necessary to remove a genitourinary organ affected by cancer. Dr. Lesani has a special interest in treating men and women with cancers of the kidney as well as men with prostate cancer.

He adheres to the philosophy that "It is not the cancer you remove from the patient but rather it is the patient you preserve from cancer."

Dr. Alex Lesani is the only urologist in Southern Nevada with fellowship training in laparoscopy and robotic surgery. He utilizes cutting-edge minimally invasive techniques to treat patients with urologic disease especially those suffering from cancer. Dr. Lesani believes if the patients are made aware of modern, less invasive options, which offer equivalent or superior results and lead to earlier recovery compared to traditional surgery, the patients would prefer these options. Take time and explore this web site and understand your treatment options.

Patterns of Repeat Prostate Biopsy Utilization in Contemporary Clinical Practice

The objectives of this study were to: 1) describe the patterns of repeat prostate biopsy utilization in men with previous negative biopsy, and 2) identify predictors of prostate cancer (CaP) diagnosis in these men on repeat biopsy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Systematic Biopsy, Targeted Biopsy or a Combination—How Should We Detect Prostate Cancer in the Future?

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Current Role of Biofeedback for Pediatric Lower Urinary Tract Symptoms

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Role of C-Choline Positron Emission Tomography in Prostate Cancer Recurrence—Potential for Delayed Cure or Just Resetting the Clock of the Disease?

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Targeted Therapies for Management of Metastatic Bladder Cancer

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Pediatric Urology

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Investigative Urology

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Adult Urology

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Treatment of Exophytic Renal Cancer Smaller than 3 cm: Surgery versus Active Surveillance

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Neuromuscular nicotinic receptors mediate bladder contractions following bladder reinnervation with somatic to autonomic nerve transfer after decentralization by spinal root transection

This study investigates whether the reinnervated neuronal pathway mediates contraction via the same neurotransmitter and receptor mechanisms as the original pathway. Following bladder decentralization by transection of sacral roots, peripheral nerve transfer was performed with bilateral genitofemoral to pelvic nerve transfer (GFNT) and unilateral (left) femoral nerve to bilateral pelvic nerve transfer (FNT). Reinnervation was assessed 7.5 months post operatively by monitoring bladder pressure during electrical stimulation of the transferred nerves, spinal ventral roots, and spinal cord.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Does this Man with Lower Urinary Tract Symptoms have Bladder Outlet Obstruction? The Rational Clinical Examination: A Systematic Review

K. A. D’Silva, P. Dahm and C. L. Wong

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Surgical Intervention for Symptomatic Benign Prostatic Hyperplasia is Correlated with Expression of the AP-1 Transcription Factor Network

O. Lin-Tsai, P. E. Clark, N. L. Miller, J. H. Fowke, O. Hameed, S. W. Hayward and D. W. Strand

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Promising Molecular Targets and Biomarkers for Male BPH and LUTS

M. Gharaee-Kermani and J. A. Macoska

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Ultrasound as a Screening Test for Genitourinary Anomalies in Children with UTI

C. P. Nelson, E. K. Johnson, T. Logvinenko and J. S. Chow

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Age at Orchidopexy as an Indicator of the Quality of Regional Child Health Services

C. J. Bruijnen, H. D. Vogels and S. W. Beasley

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Analysis of 3,776 Pediatric Inguinal Hernia and Hydrocele Cases in a Tertiary Center

D. Erdoğan, I. Karaman, M. K. Aslan, A. Karaman and Y. H. Cavuşoğlu

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Postpubertal Examination after Hypospadias Repair is Necessary to Evaluate the Success of the Primary Reconstruction

A. N. Ekmark, H. Svensson, E. Arnbjörnsson and E. Hansson

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Primary Testicular Lymphoma

A 69-year-old man presented with painless left scrotal swelling 2 weeks in duration. He denied trauma or recent injury as well as fever, dysuria, gross hematuria, night sweats and weight loss. Physical examination revealed an enlarged, firm left testis with suspected superior cystic component. Alpha fetal protein and beta-human chorionic gonadotropin were within normal limits but lactate dehydrogenase was elevated at 373 U/L (normal 100-220 U/L).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Male Bulbospongiosus Muscle and its Relation to the External Anal Sphincter

The bulbospongiosus muscle (BSM) is part of the superficial muscular layer of the perineum and pelvic floor. Its morphology remains controversial in the literature. Therefore, the fascial arrangement and fibre courses of the BSM, and its topographical relation to the external anal sphincter (EAS) were reinvestigated.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Pilot Randomized Controlled Trial Evaluating the Effectiveness of Group Versus Individual Urotherapy in Reducing Symptoms Associated With Bladder Bowel Dysfunction

To determine the feasibility of a definitive trial comparing the effectiveness of group urotherapy (GU) versus individual urotherapy (IU) for children with bladder bowel dysfunction (BBD).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Etiology of Azoospermia in a Military Population

and Objectives: Male infertility is commonly seen in urology clinics and 10−20% of infertile males will be found to be azoospermic. Azoospermia is classically categorized as nonobstructive (NOA) or obstructive (OA). This classification tailors the evaluation, diagnosis and proper treatment. Our retrospective study was designed to provide an updated etiology of azoospermia among patients in the US within a universal health care model.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Cystic Nephroma of the Kidney

A 65-year-old female presented to the emergency room with shortness of breath. Chest CT revealed a pulmonary embolus. Incidentally, the CT revealed a large, complex cystic lesion of the left kidney. Followup imaging confirmed a 16 cm Bosniak III cystic lesion. After reviewing management options, the patient elected laparoscopic radical nephrectomy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Extended Outcomes in the Treatment of Male Stress Urinary Incontinence with a Transobturator Sling

J. M. Zuckerman, B. Edwards, K. Henderson, H. A. Beydoun and K. A. McCammon

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prevention of Recurrent Ischemic Priapism with Ketoconazole: Evolution of a Treatment Protocol and Patient Outcomes

M. P. Hoeh and L. A. Levine

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Outcomes of Abdominal Wall Reservoir Placement in Inflatable Penile Prosthesis Implantation: A Safe and Efficacious Alternative to the Space of Retzius

D. S. Stember, B. B. Garber and P. E. Perito

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: A Guide for Inflatable Penile Prosthesis Reservoir Placement: Pertinent Anatomical Measurements of the Retropubic Space

G. Henry, W. Hsiao, E. Karpman, A. J. Bella, R. Carrion, L. Jones, B. Christine, E. Eisenhart, M. A. Cleves and A. Kramer

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Safety, Minimization, and Awareness Radiation Training Reduces Fluoroscopy Time during Unilateral Ureteroscopy

L. R. Weld, U. O. Nwoye, R. B. Knight, T. S. Baumgartner, J. S. Ebertowski, M. T. Stringer, M. C. Kasprenski and K. J. Weld

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Predicting Urinary Stone Composition Based on Single-Energy Noncontrast Computed Tomography: The Challenge of Cystine

F. C. Torricelli, G. S. Marchini, S. De, K. G. Yamaçake, E. Mazzucchi and M. Monga

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Adverse Events Resulting from Lasers Used in Urology

A. M. Althunayan, M. A. Elkoushy, M. M. Elhilali and S. Andonian

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prostate Volume Correlates with Diabetes in Elderly Benign Prostatic Hyperplasia Patients

X. Qu, Z. Huang, X. Meng, X. Zhang, L. Dong and X. Zhao

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Cost-Effectiveness of Cranberry Capsules to Prevent Urinary Tract Infection in Long-Term Care Facilities: Economic Evaluation with a Randomized Controlled Trial

W. B. van den Hout, M. A. Caljouw, H. Putter, H. J. Cools and J. Gussekloo

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Effectiveness of Cranberry Capsules to Prevent Urinary Tract Infections in Vulnerable Older Persons: A Double-Blind Randomized Placebo-Controlled Trial in Long-Term Care Facilities

M. A. Caljouw, W. B. van den Hout, H. Putter, W. P. Achterberg, H. J. Cools and J. Gussekloo

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Clinical Outcomes and Patient Satisfaction Rates among Elderly Male Aged ≥75 Years with Inflatable Penile Prosthesis Implant for Medically Refractory Erectile Dysfunction

E. Chung, M. Solomon, L. DeYoung and G. B. Brock

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Determinants of Sexual Activity in Four Birth Cohorts of Swedish 70-Year-Older Examined 1971-2001

N. Beckman, M. Waern, S. Östling, V. Sundh and I. Skoog

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Protective effect of 2-aminoethoxydiphenyl borate on testicular ischemia reperfusion injury in rats

This study aims to assess the effects of 2-APB on I/R-induced testicular damage via biochemical and histopathological evaluation.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Is Top-Down Approach Really Less Stressful for the Child and Family Compared to Bottom-Up Approach: Challenging the Dogma

We aimed to evaluate whether stress-levels in children & parents raised with radiological work up after febrile UTI are really less in Top-Down (TD) fashion where DMSA takes main-role, than bottom-up (BU) approach where VCUG is initially performed & repeated examinations are easier for all.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Hereditary-Like Urothelial Carcinomas of the Upper Urinary Tract Benefit More from Adjuvant Cisplatin-Based Chemotherapy after Radical Nephroureterectomy than do Sporadic Tumours

C. Hollande, P. Colin, T. de La Motte Rouge, F. Audenet, D. R. Yates, V. Phé, A. Ouzzane, S. Droupy, A. Ruffion, A. de La Taille, L. Guy, O. Cussenot, F. Rozet, E. Xylinas, M. Zerbib, J. P. Spano, D. Khayat, M. O. Bitker and M. Rouprêt; French Collaborative National Working-Group on UTUC

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: ClearCode34: A Prognostic Risk Predictor for Localized Clear Cell Renal Cell Carcinoma

S. A. Brooks, A. R. Brannon, J. S. Parker, J. C. Fisher, O. Sen, M. W. Kattan, A. A. Hakimi, J. J. Hsieh, T. K. Choueiri, P. Tamboli, J. K. Maranchie, P. Hinds, C. R. Miller, M. E. Nielsen and W. K. Rathmell

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Lack of Testicular Seipin Causes Teratozoospermia Syndrome in Men

M. Jiang, M. Gao, C. Wu, H. He, X. Guo, Z. Zhou, H. Yang, X. Xiao, G. Liu and J. Sha

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Neurosensory Perception of Environmental Cues Modulates Sperm Motility Critical for Fertilization

K. McKnight, H. D. Hoang, J. K. Prasain, N. Brown, J. Vibbert, K. A. Hollister, R. Moore, J. R. Ragains, J. Reese and M. A. Miller

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Understanding the Pharmacological Properties of a Metabolic PET Tracer in Prostate Cancer

N. T. Viola-Villegas, S. D. Carlin, E. Ackerstaff, K. K. Sevak, V. Divilov, I. Serganova, N. Kruchevsky, M. Anderson, R. G. Blasberg, O. A. Andreev, D. M. Engelman, J. A. Koutcher, Y. K. Reshetnyak and J. S. Lewis

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Impact of an adjuvant chemotherapeutic regimen on the clinical outcome in high-risk patients with upper tract urothelial carcinoma: A Japanese multi-institution experience

and Objective: Current guidelines do not yet provide any recommendations for adjuvant chemotherapy in patients with upper tract urothelial carcinoma (UTUC) managed with radical nephroureterectomy (RNU). We evaluated whether an adjuvant chemotherapeutic regimen would affect the clinical outcome in high-risk UTUC patients.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prospective Evaluation of a Preoperative Biomarker Panel for Prediction of Upstaging at Radical Cystectomy

S. F. Shariat, N. Passoni, A. Bagrodia, V. Rachakonda, E. Xylinas, B. Robinson, P. Kapur, A. I. Sagalowsky and Y. Lotan

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Clinical-Pathologic Stage Discrepancy in Bladder Cancer Patients Treated with Radical Cystectomy: Results from the National Cancer Data Base

P. J. Gray, C. C. Lin, A. Jemal, W. U. Shipley, S. A. Fedewa, A. S. Kibel, J. E. Rosenberg, A. M. Kamat, K. S. Virgo, M. L. Blute, A. L. Zietman and J. A. Efstathiou

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Postnatal germ cell development during minipuberty in the mouse does not require androgen receptor: implications for managing cryptorchidism

Undescended testis (UDT) leads to infertility and malignancy resulting from aberrant germ cell (GC) development. Androgens are proposed to control early GC development during the transient postnatal surge of gonadotropins and androgen, known as mini-puberty. We aim to assess the effect of androgen receptor on perinatal GC development in mice.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Effects of new single-step posterior reconstruction method on recovery of continence after robot-assisted laparoscopic prostatectomy: Results from a prospective, single-blind, parallel group, randomized controlled trial

We devised a single-step posterior reconstruction (PR) technique, which opposes the median dorsal raphe solely to the posterior counterpart of the detrusor apron, rather than to the Denonvilliers’ fascia. We previously found that during robot-assisted laparoscopic prostatectomy (RALP) this new technique could significantly shortens continence recovery time through a retrospective study. We designed a prospective clinical trial to confirm it.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Humoral Pattern Recognition Molecule PTX3 is a Key Component of Innate Immunity against Urinary Tract Infection

S. Jaillon, F. Moalli, B. Ragnarsdottir, E. Bonavita, M. Puthia, F. Riva, E. Barbati, M. Nebuloni, L. Cvetko Krajinovic, A. Markotic, S. Valentino, A. Doni, S. Tartari, G. Graziani, A. Montanelli, Y. Delneste, C. Svanborg, C. Garlanda and A. Mantovani

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Influence of Urinary pH on Antibiotic Efficacy against Bacterial Uropathogens

L. Yang, K. Wang, H. Li, J. D. Denstedt and P. A. Cadieux

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Lateral Temperature Spread of Monopolar, Bipolar and Ultrasonic Instruments for Robot-Assisted Laparoscopic Surgery

L. J. Hefermehl, R. A. Largo, T. Hermanns, C. Poyet, T. Sulser and D. Eberli

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: One- vs 4-Week Stent Placement after Laparoscopic and Robot-Assisted Pyeloplasty: Results of a Prospective Randomised Single-Centre Study

H. Danuser, C. Germann, N. Pelzer, A. Rühle, P. Stucki and A. Mattei

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Does Extracorporeal Shock Wave Lithotripsy Cause Hearing Impairment In Children?

To evaluate the possible effects of noise created by High Energy Shock Waves (HESW) on the hearing function of children treated with Extracorporeal Shockwave Lithotripsy (SWL).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Usage and Results of a Mobile App for Managing Urinary Incontinence

Slight changes in urinary incontinence (UI) severity may be difficult to notice, leading even high-functioning patients to be unable to detect if their UI is getting better or worse. We describe a recently released free software app, iDry®, that enables individuals with UI to document incontinence symptoms, view progress, evaluate effectiveness of interventions, and report status to their healthcare provider. Following two field trials, iDry was published as a free download from the Apple App Store, and was downloaded 1,231 times in the first 19 months.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Multiparametric MRI of the Bladder: Ready for Clinical Routine?

R. J. de Haas, M. J. Steyvers and J. J. Fütterer

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Testicular Cancer Incidence to Rise by 25% in Europe? Model-Based Predictions in 40 Countries Using Population-Based Registry Data

C. Le Cornet, J. Lortet-Tieulent, D. Forman, R. Béranger, A. Flechon, B. Fervers, J. Schüz and F. Bray

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Transplantation between Monozygotic Twins: How Identical are They?

E. Day, P. K. Kearns, C. J. Taylor and J. A. Bradley

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Reducing Postoperative Venous Thromboembolism Complications with a Standardized Risk-Stratified Prophylaxis Protocol and Mobilization Program

M. R. Cassidy, P. Rosenkranz and D. McAneny

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Pediatric Urology: Evidence for Optimal Patient Management

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

"A prospective, randomized and controlled trial for the treatment of anterior vaginal wall prolapse: Medium-term follow-up"

To compare the efficacy and safety of the anterior colporrhaphy (AC) with transvaginal polypropylene mesh (PM) insertion for the treatment of anterior vaginal wall prolapse (AVWP) at medium-term follow-up.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Lithotripter Outcomes in a Community Practice Setting: Comparison of the LithoGold LG-380 and Storz Modulith SLX

Assess patient outcomes using two widely different contemporary lithotripters.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Bladder Volume at Onset of Vesicoureteral Reflux is an Independent Risk Factor for Breakthrough Febrile Urinary Tract Infection

Improved identification of children with vesicoureteral reflux (VUR) at risk for recurrent febrile urinary tract infection (fUTI) may impact management decisions. We hypothesized that VUR occurring earlier during bladder filling increases the duration of exposure of these kidneys to bacteria and therefore increase the risk of pyelonephritis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

TEMPORARY REMOVAL: Estimating the Nationwide Hospital-Based Economic Impact of Pediatric Urolithiasis

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

TEMPORARY REMOVAL: Patient and Institutional Characteristics Associated with Initial CT Use for Children Presenting to the Emergency Department with Kidney Stones

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

TEMPORARY REMOVAL: Early Effect of American Academy of Pediatrics UTI Guidelines on Radiographic Imaging and Diagnosis of Vesicoureteral Reflux in the Emergency Room Setting

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

TEMPORARY REMOVAL: Bullying plays a potential role in pediatric lower urinary tract symptoms

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Anatomical study of pelvic nerves in relation to seminal vesicles, prostate and urethral sphincter: immunohistochemical staining, computerised planimetry and three-dimensional reconstruction

Studies of male pelvic neuroanatomy are mandatory to improve functional outcome following radical prostatectomy. Purpose was a topographical investigation of nerves on their course from the seminal vesicles (SV) along the prostate towards the striated urethral sphincter (SS).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

TEMPORARY REMOVAL: Structural Study of Gubernaculum Testis in Fetuses with Prune Belly Syndrome

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

TEMPORARY REMOVAL: Multi-Institutional Review of Outcomes of Robot-Assisted Laparoscopic Extravesical Ureteral Reimplantation

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

TEMPORARY REMOVAL: Transcriptional dysregulation in the ureteric bud causes multicystic dysplastic kidney by branching morphogenesis defect

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

The age cutoff was addressed in the article and was based on the number of subjects sufficient to allow group comparisons. Furthermore, when the study was originally planned several years ago, the predominant age cutoff was 65 years. Although 65 years is still commonly used, one could argue that in some countries where people live longer an older cutoff should be considered in future publications on this subject.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

We, too, believe that bipolar resection does not eliminate obturator jerk. However, we have shown that this approach has the potential to improve the quality of tissue for histopathological examination. Therefore, further research needs to be done to determine optimal settings that will allow adequate resection with minimal stimulation of the nerve, thereby minimizing complications. Ultimately it is likely that alterations in anesthetic technique, such as using general anesthesia or obturator block, will have the most impact in this area.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Evaluation of Transobturator Tension-Free Vaginal Tapes in the Surgical Management of Mixed Urinary Incontinence: 3-Year Outcomes of a Randomized Controlled Trial

We read this article with great interest and appreciate the work of the authors. They evaluated outcomes for urgency and urgency incontinence (UI) symptoms at 3 years postoperatively using the BBUQ-22 (Birmingham Bowel Urinary symptom Questionnaire). Postoperative urgency and UI cure rates have been defined as 2-point improvement or greater on the relevant BBUQ-22 question. At 3 years 34 women (51.1%) reported cure/significant improvement in urgency symptoms, compared to 37 (56.1%) at 1 year. The authors observed a UI cure rate of 56.5% (26 of 46 patients) at 3-year followup, with 71% of women reporting improvement.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Defining the Potential of Neoadjuvant Chemotherapy Use as a Quality Indicator for Bladder Cancer Care

We were pleased to read this article on the role of chemotherapy in muscle invasive bladder cancer. What has been highlighted by the publication of such articles is the insufficient evidence for the use of neoadjuvant chemotherapy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Effect of Aging on Storage and Voiding Function in Women with Stress Predominant Urinary Incontinence

The authors investigated age related changes in urodynamic parameters of patients with predominant stress urinary incontinence from 2 cohorts of women included in 2 large trials. The results confirm previous studies.1–3

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Monopolar versus Bipolar Transurethral Resection of Bladder Tumors: A Single Center, Parallel Arm, Randomized, Controlled Trial

We read with interest this article on the comparison of monopolar and bipolar transurethral resection of bladder tumor (TURBT). We support the idea that bipolar TURBT is not superior to monopolar resection regarding obturator nerve reflex. The incidence of obturator jerk was 49.2% in the monopolar arm and 60% in the bipolar arm, which is not significantly different. The data were reliable because only tumors on the lateral wall were included and no obturator nerve block was used. TURBT has been considered the standard treatment for patients with nonmuscle invasive bladder cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

Biofeedback for nonneuropathic voiding disorders has slowly gained popularity since it was first introduced.1,2 There is as yet no standardized method of recruiting patients who would be suitable for this therapy, no standard therapeutic protocol for its administration and no uniformity in the evaluation of outcome/results. Therefore, it was a challenging task for the authors to select appropriate studies to include in their meta-analysis and, as could be expected, the available number of series for review was limited.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Provider Variation in the Quality of Metabolic Stone Management

Urinary stone disease is a chronic condition for which secondary prevention, in the form of dietary and medical therapy, guided by the results of the 24-hour urine collection, plays an important role. Assessing response to these interventions with follow-up testing is recommended, yet provider compliance with these guidelines is unknown.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Pazopanib as third-line therapy for metastatic renal cell carcinoma: Clinical efficacy and temporal analysis of cytokine profile

Pazopanib has been assessed primarily in cytokine-refractory or treatment-naïve patients with metastatic renal cell carcinoma (mRCC), and outcomes have been associated with a specific immunologic profile (IP). The activity of pazopanib in the third-line setting and temporal changes in IP during therapy are poorly understood, however.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Efficacy and Safety of MCNA in Patients with Non-Muscle Invasive Bladder Cancer at High-Risk of Recurrence and Progression who Have Failed Treatment with Bacillus Calmette–Guérin

Patients with high-risk recurrences after BCG failure have limited options. We performed an open-label study to evaluate the efficacy and safety of intravesical MCNA in this setting.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Canalization of The Urethral Plate Precedes Fusion of The Urethral Folds During Male Penile Urethral Development: The Double Zipper Hypothesis

We describe the “double zipper”, mechanism of human male urethral formation where the distal zipper opens the urethral groove through canalization of the urethral plate, and a second closing zipper follows behind and closes the urethral groove to form the tubular urethra.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Galectin-1 Dysregulation Independently Predicts Disease-Specific Survival In Urinary Bladder Urothelial Carcinoma

Galectin-1 is highly expressed in various tumours and participates in various oncogenic processes. Our previous proteomics investigation demonstrated that galectin-1 is up-regulated in high grade tumours compared to non-high grade lesions. Thus the present cohort study was to clarify the correlation of galectin-1 over-expression with various clinicopathologic features and prognosis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The findings in this cohort study suggest that nephron preservation is associated with a decreased risk of hypertension following bilateral WT excision. Perhaps more interesting are the questions that this study raises about the development of hypertension and the natural history of renal function in children with bilateral WT after NSS. Abnormal renal function markers (increased serum creatinine, albuminuria and proteinuria) were observed only in patients who had undergone TN/PN, and all occurred less frequently than hypertension.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Randomized, Double-Blind, Solifenacin Succinate vs Placebo-Control Phase 4, Multi-Center Study Evaluating Urinary Continence after Robotic Assisted Radical Prostatectomy

Bladder dysfunction influences recovery of urinary continence after radical prostatectomy. We performed a multi-center, randomized, double-blind study evaluating Solifenacin vs placebo on return to continence in patients who were still incontinent 7-21 days after catheter removal following RARP.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Teasing in School Locker Rooms Regarding Penile Appearance

Parents of young boys seeking circumcision or circumcision revision commonly cite concern that their sons may be teased in middle or high school because of their penile appearance. There is no current data to substantiate or refute the presence of such teasing. We explored the validity of this concern by investigating the extent and frequency of teasing regarding penile appearance.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Meta-analysis of the Performance of Retropubic Midurethral Slings vs. Transobturator Midurethral Slings

To evaluate efficacy and complications after retropubic midurethral slings (RMS) and transobturator midurethral slings (TMS) in the treatment of female stress urinary incontinence (SUI).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Pelvic arterial occlusive disease affects the RhoA/Rho-kinase pathway in bladder smooth muscle

To investigate the effect of pelvic arterial occlusive disease on the RhoA/Rho-kinase (ROK) pathway in a rat model of chronic bladder ischemia.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Long-term follow-up of adult men born with hypospadias: Urological and cosmetic results

To present data on long-term functional and cosmetic results after hypospadias surgery.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Shear wave elastography for localization of prostate cancer lesions and assessment of elasticity thresholds: Implications for targeted biopsies and active surveillance protocols

Shear wave elastography (SWE) allows cancer detection by using focused ultrasound pulses for locally deforming tissue. These differences in tissue elasticity and stiffness are increasingly used in breast cancer imaging and also help detect potential tumor lesions within the prostate.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Highly-Trained Dogs’ Olfactory System Detects Prostate Cancer in Urine Samples

To establish the diagnostic accuracy, in term of sensitivity and specificity at which a rigorously trained canine olfactory system can recognize prostate cancer (PC)-specific volatile organic compounds (VOCs) in urine samples.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Quality of life improvement for patients treated with degarelix versus leuprorelin in advanced prostate cancer

We have used responses to questionnaires included in the CS21 degarelix trial and published mapping algorithms to address the paucity of evidence for health-related quality of life (HRQL) for patients with advanced hormone-dependent prostate cancer treated with degarelix.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Green Light Laser (XPS) Photoselective Vapo-Enucleation of the Prostate versus Holmium Laser Enucleation of the Prostate for Treatment of Symptomatic Benign Prostate Hyperplasia: A Randomized Controlled Study

After the advent of the XPS (180W) 532nm-laser, Photoselective Vapo-Enucleation of the Prostate (PVEP) could compete with Holmium Laser Enucleation of the prostate (HoLEP) as a size independent procedure.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Lack of P16(INK4A) Over-Expression in Penile Squamous Cell Carcinoma is Associated with Recurrence After Lymph Node Dissection

There have been conflicting data in studies on the prognostic role of high-risk human papillomavirus (HR-HPV) in penile squamous cell carcinoma. Using P16ink4a over-expression as a surrogate marker for HR-HPV, we evaluated HR-HPV status with respect to various clinical features, including recurrence, overall survival, etc.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Population-Based Study of the Changing Demographics of Patients Undergoing Definitive Treatment for Kidney Stone Disease

To examine temporal changes in the demographics of patients undergoing definitive treatment for kidney stones over a 20-year period in Ontario, Canada.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Complications in Surgical Management of Upper Tract Calculi in Spina Bifida Patients: Analysis of Nationwide Data

The management of upper urinary tract stones in spina bifida (SB) patients is challenging but poorly described in the literature. Our objective was to compare the treatment and related complications of urolithiasis interventions in SB patients to other stone formers using a national database.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Extended Follow-Up and Risk Factors for Disease Reclassification from a Large Active Surveillance Cohort for Localized Prostate Cancer

The use of active surveillance (AS) to manage prostate cancer (PCa) provides an alternative to immediate treatment for men with low-risk PCa. We report updated outcomes from a long-standing AS cohort and factors associated with reclassification.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Urethroplasty for high-risk, long segment urethral strictures with ventral buccal mucosa graft and gracilis muscle flap

Long-segment urethral strictures with a compromised graft bed and poor vascular supply are unfit for standard repair, and are at high-risk for stricture recurrence. Our objective was to assess the success of urethral reconstruction in these patients with a ventral buccal mucosa graft (BMG) and gracilis muscle flap (GMF).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The relationship between total testosterone levels and prostate cancer: A review of the continuing controversy

For many years it was believed that higher total testosterone levels (TT) contributed to prostate cancer (PCa) development and caused rapid cancer growth. International guidelines consider that adequate data are not available to determine whether there is any additional risk of PCa from testosterone replacement. Numerous studies with multiple designs and contradictory conclusions have investigated the relationship between TT and the development of PCa. To establish the current knowledge in this field, we reviewed the literature regarding TT and the subsequent risk of development of PCa as well as the safety of exogenous testosterone administration to patients with a past or current history of PCa.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Clinical Outcomes in cT1 Micropapillary Bladder Cancer

While many urologists recommend radical cystectomy for patient with micropapillary bladder cancer (MPBC) invading the lamina propria (cT1), contradictory small reports exist regarding the efficacy of conservative management with intravesical BCG for this disease. Herein we report our updated experience with largest series of patients with cT1 MPBC.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A randomized controlled study to evaluate the efficacy of tamsulosin monotherapy and its combination with mirabegron on patients with overactive bladder induced by benign prostatic obstruction

To evaluate the efficacy and safety of add-on treatment with a β3-adrenoceptor agonist (mirabegron) on overactive bladder (OAB) symptoms remaining after α1-blocker (tamsulosin) treatment in men with benign prostatic obstruction (BPO).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Impact of Bleomycin on Retroperitoneal Histology at Post-Chemotherapy Retroperitoneal Lymph Node Dissection in Good Risk Germ Cell Tumors

Induction chemotherapy for International Germ Cell Cancer Collaborative Group (IGCCCG) good-risk metastatic testicular cancer includes either 3 cycles of bleomycin, etoposide, and cisplatin (BEP) or 4 cycles of etoposide and cisplatin (EP). We sought to examine differences in active cancer in the retroperitoneum (RP) between patients receiving BEPx3 compared to EP x4.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Cytoreductive Radical Prostatectomy in Patients with prostate cancer and low volume skeletal metastases – results of a feasibility and case-control study

Androgen deprivation (ADT) represents the standard treatment for PCA with osseous metastases. We explored the role of cytoreductive radical prostatectomy in PCA with low volume skeletal metastases in terms of a feasibility study.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

A laparoscopic approach to cystectomy faced an uphill task of achieving efficacy and maneuverability with straight sticks by even the most talented surgeons. Evolution of robot-assisted surgery for bladder cancer has completed more than a decade of progress.1,2 The primary goal was to satisfy the basic tenets of oncologic safety in extirpation and node removal. Prolonged operative duration, limitations of conventional laparoscopy and the need to master the human-machine interface made early adaption of complete intracorporeal surgery challenging.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Home Study Course 2014 Volume 191/192

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Retroperitoneal Angiolipoma

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Robotic Radical Cystectomy—Is the Diversion the Achilles Heel?

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

In vitro and in vivo experiments on electrochemotherapy for bladder cancer

Electrochemotherapy is widely used for treatment of solid tumors; however experience in bladder cancer is limited.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Success of Autologous Pubovaginal Sling Following Failed Synthetic Midurethral Sling

There is no consensus on the management of persistent or recurrent stress incontinence (SUI) after a failed synthetic midurethral sling. After a mesh complication or sling failure many women and surgeons prefer to avoid a repeat mesh procedure and chose an autologous pubovaginal slings (APVS), however little empirical work has been performed to assess the efficacy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Effect of renal shock wave lithotripsy on the development of metabolic syndrome in a juvenile swine model: a pilot study

A pilot study was conducted to assess whether renal shock wave lithotripsy (SWL) influences the onset and severity of metabolic syndrome (MetS).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Pentosan Polysulfate Sodium for Treatment of Interstitial Cystitis/Bladder Pain Syndrome: Insights from a Randomized, Double-Blind, Placebo-Controlled Study

To compare the efficacy and safety of the currently recommended dose of pentosan polysulfate sodium (PPS) with one-third of the daily dose and with placebo.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Repeated Variate Stress in Male Rats Induces Increased Voiding Frequency, Somatic Sensitivity, and Urinary Bladder Nerve Growth Factor Expression

L. Merrill, S. Malley and M. A. Vizzard

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Postpartum Pelvic Floor Muscle Training and Urinary Incontinence: A Randomized Controlled Trial

G. Hilde, J. Stær-Jensen, F. Siafarikas, M. Ellström Engh and K. Bø

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Global Prevalence and Economic Burden of Urgency Urinary Incontinence: A Systematic Review

I. Milsom, K. S. Coyne, S. Nicholson, M. Kvasz, C. I. Chen and A. J. Wein

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Nocturia Causes Vary with Each Decade

J. N. Graham, Jr., B. R. Desroches and J. P. Weiss

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Update on Behavioral and Physical Therapies for Incontinence and Overactive Bladder: The Role of Pelvic Floor Muscle Training

K. L. Burgio

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Weaker Masturbatory Erection May Be a Sign of Early Cardiovascular Risk Associated with Erectile Dysfunction in Young Men without Sexual Intercourse

Y. P. Huang, B. Chen, F. J. Yao, S. F. Chen, B. Ouyang, C. H. Deng and Y. R. Huang

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Effect of Condoms on Penile Vibrotactile Sensitivity Thresholds in Young, Heterosexual Men

B. J. Hill, E. Janssen, P. Kvam, E. E. Amick and S. A. Sanders

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Modern Utilization of Penile Prosthesis Surgery: A National Claim Registry Analysis

R. L. Segal, S. B. Camper and A. L. Burnett

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: High Patient Satisfaction of Inflatable Penile Prosthesis Insertion with Synchronous Penile Plication for Erectile Dysfunction and Peyronie’s Disease

P. H. Chung, J. F. Scott and A. F. Morey

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: A Population-Based Analysis of Contemporary Rates of Reoperation for Penile Prosthesis Procedures

S. Grewal, J. Vetter, S. B. Brandes and S. A. Strope

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Effects of Assisted Reproductive Technologies on Human Sex Ratio at Birth

W. E. Maalouf, M. N. Mincheva, B. K. Campbell and I. C. Hardy

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Phenotypic Differences in Mosaic Klinefelter Patients as Compared with Non-Mosaic Klinefelter Patients

M. K. Samplaski, K. Lo, E. D. Grober, A. Millar, A. Dimitromanolakis and K. A. Jarvi

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Obese Father’s Metabolic State, Adiposity, and Reproductive Capacity Indicate Son’s Reproductive Health

N. O. McPherson, T. Fullston, H. W. Bakos, B. P. Setchell and M. Lane

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Obesity is Associated with Increased Seminal Insulin and Leptin alongside Reduced Fertility Parameters in a Controlled Male Cohort

K. Leisegang, P. J. Bouic, R. Menkveld and R. R. Henkel

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Affordable Care Act: Early Implications for Fertility Medicine

K. Devine, R. J. Stillman and A. H. DeCherney

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Improvement of Erectile Function in Patients with Benign Prostatic Hyperplasia Undergoing Transurethral Plasmakinetic Resection of the Prostate

H. M. Zhang, J. H. Zheng, Y. F. Xu, B. Peng, Y. Yan and Q. R. Gao

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Prognostic Use of Inflammation and Tissue Necrosis in Benign Prostatic Hyperplasia

J. M. Willder, V. C. Walker, G. L. Halbert, C. P. Dick, C. Orange, T. Qayyum, P. G. Horgan, M. A. Underwood and J. Edwards

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Minimally Invasive Prostatic Urethral Lift: Surgical Technique and Multinational Experience

T. A. McNicholas, H. H. Woo, P. T. Chin, D. Bolton, M. Fernández Arjona, K. D. Sievert, M. Schoenthaler, U. Wetterauer, E. J. Vrijhof, S. Gange and F. Montorsi

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Clinical, Laboratorial, and Urodynamic Findings of Prostatic Artery Embolization for the Treatment of Urinary Retention Related to Benign Prostatic Hyperplasia. A Prospective Single-Center Pilot Study

A. A. Antunes, F. C. Carnevale, J. M. da Motta Leal Filho, E. M. Yoshinaga, L. M. Cerri, R. H. Baroni, A. S. Marcelino, G. G. Cerri and M. Srougi

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Low Prolactin is Associated with Sexual Dysfunction and Psychological or Metabolic Disturbances in Middle-Aged and Elderly Men: The European Male Aging Study (EMAS)

G. Corona, F. C. Wu, G. Rastrelli, D. M. Lee, G. Forti, D. B. O’Connor, T. W. O’Neill, N. Pendleton, G. Bartfai, S. Boonen, F. F. Casanueva, J. D. Finn, I. T. Huhtaniemi, K. Kula, M. Punab, D. Vanderschueren, M. K. Rutter and M. Maggi; EMAS Study Group

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Quantitative Histological Analysis and Ultrastructure of the Aging Human Testis

H. Jiang, W. J. Zhu, J. Li, Q. J. Chen, W. B. Liang and Y. Q. Gu

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Long-Term Safety, Tolerability and Efficacy of Flexible-Dose Fesoterodine in Elderly Patients with Overactive Bladder: Open-Label Extension of the SOFIA Trial

A. Wagg, V. Khullar, M. C. Michel, M. Oelke, A. Darekar and C. E. Bitoun

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Urinary Incontinence as a Marker of Higher Mortality in Patients Receiving Home Care Services

G. John, E. Gerstel, M. Jung, P. Dällenbach, D. Faltin, V. Petoud, C. Zumwald and O. T. Rutschmann

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Detrusor Underactivity and the Underactive Bladder: A New Clinical Entity? A Review of Current Terminology, Definitions, Epidemiology, Aetiology, and Diagnosis

N. I. Osman, C. R. Chapple, P. Abrams, R. Dmochowski, F. Haab, V. Nitti, H. Koelbl, P. van Kerrebroeck and A. J. Wein

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Anorectal Malformations and Potential Urological Problems—What is the Pediatric Urologist’s Role?

The impact of anorectal malformations (ARM)/cloacal anomalies on eventual urinary tract function can vary greatly in extent and timing. There has been and still is a concern about which of the 3 potential etiologies of urinary incontinence and bladder changes is the most important. Whether eventual incontinence is due to 1) an inherent congenital anatomical/neurological abnormality that occurs to various degrees in many patients with ARM, 2) a consequence of surgical reconstruction to restore normal anatomy or 3) a late presenting neurological issue (eg tethered cord) or any combination of these is still poorly understood.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Is There Still a Role for Primary Realignment in Stricture Due to Pelvic Fracture?

As is often the case, the devil is in the details. In this issue of The Journal Tausch et al (page 000) report on the unintended consequences of primary realignment, although that is not to say there is no role for primary realignment.1 Rather, if primary realignment is considered a definitive therapy, then appropriate referrals may not occur.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparative Effectiveness of Robot-Assisted and Open Radical Prostatectomy in the Postdissemination Era

G. Gandaglia, J. D. Sammon, S. L. Chang, T. K. Choueiri, J. C. Hu, P. I. Karakiewicz, A. S. Kibel, S. P. Kim, R. Konijeti, F. Montorsi, P. L. Nguyen, S. Sukumar, M. Menon, M. Sun and Q. D. Trinh

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The daily use of PDE5 inhibitors to prevent sexual dysfunction (so-called “penile rehabilitation”) following treatment for localized prostate cancer has become fairly commonplace in clinical practice, although the evidence for this approach is not as definitive as some might like. This small randomized clinical trial fails to show a benefit of routine PDE5 inhibitor use in patients undergoing radiotherapy for prostate cancer. While we cannot necessarily extrapolate the results to the postoperative setting, there is little doubt that insurance companies will.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Tadalafil for Prevention of Erectile Dysfunction after Radiotherapy for Prostate Cancer: The Radiation Therapy Oncology Group [0831] Randomized Clinical Trial

T. M. Pisansky, S. L. Pugh, R. E. Greenberg, N. Pervez, D. R. Reed, S. A. Rosenthal, R. B. Mowat, A. Raben, M. K. Buyyounouski, L. A. Kachnic and D. W. Bruner

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Risk of Late Toxicity in Men Receiving Dose-Escalated Hypofractionated Intensity Modulated Prostate Radiation Therapy: Results from a Randomized Trial

K. E. Hoffman, K. R. Voong, T. J. Pugh, H. Skinner, L. B. Levy, V. Takiar, S. Choi, W. Du, S. J. Frank, J. Johnson, J. Kanke, R. J. Kudchadker, A. K. Lee, U. Mahmood, S. E. McGuire and D. A. Kuban

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Primary Realignment vs Suprapubic Cystostomy for the Management of Pelvic Fracture-Associated Urethral Injuries: A Systematic Review and Meta-Analysis

K. Barrett, L. H. Braga, F. Farrokhyar and T. O. Davies

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Multi-Institutional 1-Year Bulbar Urethroplasty Outcomes Using a Standardized Prospective Cystoscopic Follow-up Protocol

B. A. Erickson, S. P. Elliott, B. B. Voelzke, J. B. Myers, J. A. Broghammer, T. G. Smith, III, C. D. McClung, N. F. Alsikafi and W. O. Brant; Trauma and Reconstructive Network of Surgeons (TURNS)

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Iatrogenic Nonendoscopic Bladder Injuries over 24 Years: 127 Cases at a Single Institution

B. H. Cordon, J. A. Fracchia and N. A. Armenakas

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Pre-emptive Penile Ring Block with Sucrose Analgesia Reduces Pain Response to Neonatal Circumcision

C. F. Roman-Rodriguez, T. Toussaint, D. J. Sherlock, J. Fogel and C. D. Hsu

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Functional Urethral Obstruction following Tubularised Incised Plate Repair of Hypospadias

A. T. Hadidi

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prepubertal Male Genitourinary Metastatic Crohn’s Disease: Report of a Case and Review of Literature

H. S. Mirheydar, S. F. Friedlander and G. W. Kaplan

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Did Antenatal Diagnosis Protect against Chronic Kidney Disease in Patients with Posterior Urethral Valves? A Multicenter Study

O. M. Sarhan, T. E. Helmy, A. A. Alotay, M. S. Alghanbar, Z. M. Nakshabandi and A. T. Hafez

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Differences in 24-H Urine Composition between Nephrolithiasis Patients with and without Diabetes Mellitus

C. Hartman, J. I. Friedlander, D. M. Moreira, S. E. Elsamra, A. D. Smith and Z. Okeke

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Dietary Interventions for Preventing Complications in Idiopathic Hypercalciuria

J. Escribano, A. Balaguer, M. Roqué i Figuls, A. Feliu and N. Ferre

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Diet and Risk of Kidney Stones in the Oxford Cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)

B. W. Turney, P. N. Appleby, J. M. Reynard, J. G. Noble, T. J. Key and N. E. Allen

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Children with Spinal Abnormalities Have an Increased Health Burden from Upper Tract Urolithiasis

P. Ramachandra, K. L. Palazzi, N. M. Holmes and G. Chiang

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Pediatric Urology

Although the etiology of meatal stenosis is unclear, it has been attributed to exposure of the urethral meatus to the external environment which leads to chronic inflammation and meatal scarring. Meatal stenosis is a well-recognized complication of circumcision but it also occurs in uncircumcised boys/men who have balanitis xerotica obliterans or lichen sclerosus et atrophicus. At the time of surgery one can often see inflammation on the inner prepuce along the frenulum which can extend to the glans and lead to narrowing of the urethral meatus.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Adult Urology

As robotic surgery advances, the use of total intracorporeal urinary diversion is becoming more popular along with the costs of increased operative time and potential morbidity. In this large series from the University of Southern California and the Karolinska Institute Desai et al (page 000) report on 132 patients who underwent robotic neobladder during radical cystectomy.1 Mean operative time was 7.6 hours, although some cases took as long as 13 hours, and blood loss averaged 436 cc but was as high as 2200 cc.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

Arterial hypertension and hypercholesterolemia are considered risk factors for hormonal testicular function and spermatogenesis. The authors performed an experimental study to determine whether drugs that block RAS at different levels could affect steroidogenesis in hypertensive mice due to HED. Three drugs were used, including the renin inhibitor aliskiren, the ACE inhibitor enalapril and the AT1R blocker losartan. Study parameters were the serum concentration of cholesterol, triglycerides, testosterone, estradiol and LH, and the gene and protein expression of aromatase, StAR and LH-r.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Side Effects of Bacillus Calmette-Guérin (BCG) in the Treatment of Intermediate- and High-Risk Ta, T1 Papillary Carcinoma of the Bladder: Results of the EORTC Genito-Urinary Cancers Group Randomised Phase 3 Study Comparing One-Third Dose with Full Dose and 1 Year with 3 Years of Maintenance BCG

M. Brausi, J. Oddens, R. Sylvester, A. Bono, C. van de Beek, G. van Andel, P. Gontero, L. Turkeri, S. Marreaud, S. Collette and W. Oosterlinck

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Retrospective Analysis of Survival Outcomes and the Role of Cisplatin-Based Chemotherapy in Patients with Urethral Carcinomas Referred to Medical Oncologists

F. Dayyani, C. A. Pettaway, A. M. Kamat, M. F. Munsell, K. Sircar and L. C. Pagliaro

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Deceptively Benign Appearing Urothelial Carcinoma

Several histological variants of urothelial carcinoma can simulate and be misdiagnosed as benign conditions. These include the nested variant,1,2 the microcystic variant and urothelial carcinoma with an inverted pattern of growth. The nested variant can resemble benign von Brunn nests, the microcystic variant can simulate benign cystitis cystica and inverted urothelial carcinoma can be misdiagnosed as benign inverted papilloma.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Investigative Urology

An important vasoconstrictor generated by testicular torsion is endothelin (ET)-1, mainly via its ET-A receptors, but the microcirculatory effects of ET-A receptor antagonism in the testis are not known. Using a specific ET-A receptor antagonist Bajory et al (page 0000) from Hungary studied the causative role of microcirculatory injury in torsion induced testicular damage with regard to ET-A receptor activation.1 Red blood cell velocity and pulsatile flow pattern alterations were examined by orthogonal polarization spectral imaging and microcirculatory inflammatory alterations were assessed by fluorescence intravital video microscopy after torsion followed by reperfusion.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Manipulation of a Locally Expressed Renin-Angiotensin System in the Testis: Implications for Steroidogenesis

The renin-angiotensin system (RAS) is best understood for its effects on blood pressure and fluid balance. Contemporary investigations, however, have begun to identify an expanded role for locally expressed RAS pathways that provide autocrine and paracrine functions. Multiple tissues have now been shown to harbor components of a renin-angiotensin mechanism, including the testis and the epididymis. The RAS in the male reproductive tract has been implicated in sperm maturation, maintenance of seminal plasma electrolytes and steroidogenesis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Histological study of the cavernous nerve mesh outside the periprostatic region: anatomical basis for erectile function after non-nerve-sparing radical prostatectomy

To identify the cavernous nerve (CN) mesh that exists caudal or posterior to the periprostatic region between the bilateral slings of levator ani and assess whether non-nerve-sparing radical prostatectomy can be modified.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Dutasteride and enzalutamide synergistically suppress prostate tumor cell proliferation

DHT is the main active androgen in the prostate, and plays a role in PCa progression. After ADT, active AR signaling is still active in tumor cells. Persistent intratumoral steroidogenesis and AR changes are responsible for this, which influences the efficacy of PCa treatment. We hypothesize that a combination of a SRD5A inhibitor and an antiandrogen, would both block intratumoral androgen synthesis as well as AR protein activity, and hence would act synergistically in reducing tumor cell proliferation.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Sub-centimeter Pulmonary Nodules are not associated with Disease Progression in Patients with Renal Cell Carcinoma

Renal cell carcinoma (RCC) most commonly metastasizes to the lung. Preoperative indeterminate pulmonary nodules (IPNs) occur in half of patients with localized RCC; however clinical significance remains poorly defined. We aimed to determine whether IPNs, their size, or number, are associated with RCC outcomes.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Variation in Pelvic Lymph Node Dissection Among Patients Undergoing Radical Prostatectomy by Hospital Characteristics and Surgical Approach: Results from the National Cancer Database

Clinical practice guidelines recommend pelvic lymph node dissection (PLND) at the time of surgery for intermediate or high-risk prostate cancer (PCa). Therefore, we sought to examine the relationship of PLND and detection of lymph node metastasis with hospital characteristics and surgical approach among PCa patients.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Incorporation of Detailed Family History from the Swedish Family-Cancer Database into the Prostate Cancer Prevention Trial Risk Calculator

Detailed family history offers an inexpensive alternative to genetic profiling for individual risk assessment. The objective here was to update the Prostate Cancer Prevention Trial Risk Calculator (PCPTRC) to include detailed family history.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Intraobserver and Interobserver Variability in Computed Tomography Size and Attenuation Measurements in Patients with Renal Cell Carcinoma Receiving Antiangiogenic Therapy: Implications for Alternative Response Criteria

K. M. Krajewski, M. Nishino, Y. Franchetti, N. H. Ramaiya, A. D. Van den Abbeele and T. K. Choueiri

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparison of Host Response Mechanisms Evoked by Extended Spectrum Beta Lactamase (ESBL)—and Non-ESBL-Producing Uropathogenic E. coli

I. Demirel, A. Kinnunen, A. Onnberg, B. Söderquist and K. Persson

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Long-Term Survival in Patients with Germ Cell Testicular Cancer: A Population-Based Competing-Risks Regression Analysis

G. Gandaglia, A. Becker, Q. D. Trinh, F. Abdollah, J. Schiffmann, F. Roghmann, Z. Tian, F. Montorsi, A. Briganti, P. I. Karakiewicz and M. Sun

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Attention to Surgeons and Surgical Care is Largely Missing from Early Medicare Accountable Care Organizations

J. M. Dupree, K. Patel, S. J. Singer, M. West, R. Wang, M. J. Zinner and J. S. Weissman

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Vertical Integration: Hospital Ownership of Physician Practices is Associated with Higher Prices and Spending

L. C. Baker, M. K. Bundorf and D. P. Kessler

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Steroid Receptor Coactivator-3 Regulates Glucose Metabolism in Bladder Cancer Cells through Coactivation of Hypoxia Inducible Factor 1α

W. Zhao, C. Chang, Y. Cui, X. Zhao, J. Yang, L. Shen, J. Zhou, Z. Hou, Z. Zhang, C. Ye, D. Hasenmayer, R. Perkins, X. Huang, X. Yao, L. Yu, R. Huang, D. Zhang, H. Guo and J. Yan

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Sertoli Cells Control Peritubular Myoid Cell Fate and Support Adult Leydig Cell Development in the Prepubertal Testis

D. Rebourcet, P. J. O’Shaughnessy, J. L. Pitetti, A. Monteiro, L. O’Hara, L. Milne, Y. T. Tsai, L. Cruickshanks, D. Riethmacher, F. Guillou, R. T. Mitchell, R. van’t Hof, T. C. Freeman, S. Nef and L. B. Smith

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Cross-Species Regulatory Network Analysis Identifies a Synergistic Interaction between FOXM1 and CENPF that Drives Prostate Cancer Malignancy

A. Aytes, A. Mitrofanova, C. Lefebvre, M. J. Alvarez, M. Castillo-Martin, T. Zheng, J. A. Eastham, A. Gopalan, K. J. Pienta, M. M. Shen, A. Califano and C. Abate-Shen

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Early Discharge after Laparoscopic or Robotic Partial Nephrectomy: Care Pathway Evaluation

A. Patel, S. Golan, A. Razmaria, S. Prasad, S. Eggener and A. Shalhav

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Mortality and Cardiovascular Disease among Older Live Kidney Donors

P. P. Reese, R. D. Bloom, H. I. Feldman, P. Rosenbaum, W. Wang, P. Saynisch, N. M. Tarsi, N. Mukherjee, A. X. Garg, A. Mussell, J. Shults, O. Even-Shoshan, R. R. Townsend and J. H. Silber

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Extent and Predictors of Waiting Time Geographic Disparity in Kidney Transplantation in the United States

A. E. Davis, S. Mehrotra, L. M. McElroy, J. J. Friedewald, A. I. Skaro, B. Lapin, R. Kang, J. L. Holl, M. M. Abecassis and D. P. Ladner

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Robotic Kidney Transplantation with Regional Hypothermia: Evolution of a Novel Procedure Utilizing the IDEAL Guidelines (IDEAL Phase 0 and 1)

M. Menon, R. Abaza, A. Sood, R. Ahlawat, K. R. Ghani, W. Jeong, V. Kher, R. K. Kumar and M. Bhandari

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Should Antibiotics be Given prior to Outpatient Cystoscopy? A Plea to Urologists to Practice Antibiotic Stewardship

H. W. Herr

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

As noted, the PN population in our study included only 19% of cases that were highly complex (R.E.N.A.L. 10–12) and median tumor size was only 3.5 cm. Patients with a solitary kidney, who are more likely to have large and complex tumors, were excluded from study because the primary objective was to assess the compensatory change in the contralateral kidney. We agree with the comments about the potential implications of our study and the need for further research in this area. Ideally this would include additional analysis of patients with larger, high complexity tumors in whom compensatory hypertrophy appears to be more robust.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

Few groups have investigated compensatory hypertrophy after PN (references 9 and 14 in article). These authors report that resected renal parenchymal volume was associated with compensatory hypertrophy, which will improve understanding of the physiological responses to nephrectomy. However, the study included relatively smaller tumors and few high complexity tumors. In clinical practice a major issue is the indication of PN for T1b or hilar tumors. Future investigations of postoperative renal function in patients with such tumors would be useful to select an appropriate surgical procedure (PN vs RN).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The authors report that compensatory hypertrophy of the contralateral renal unit after PN is limited with only a 2% and 5% median increase in GFR and volume, respectively. It correlates positively with the amount of parenchymal volume excised and inversely with patient comorbidity. This study highlights the need to consider volume and functional alteration of the contralateral renal unit to project overall postoperative GFR. It remains to be investigated whether similar compensation occurs in the remaining ipsilateral kidney after PN and whether its extent is impacted by the same or additional factors.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Institutional Characteristics Associated with Receipt of Emergency Care for Obstructive Pyelonephritis at Community Hospitals

Delivery of recommended care is an important quality measure insufficiently studied within the field of urology. Obstructive pyelonephritis is a suitable case study for this focus because despite guidelines advocating decompression many do not receive such care. We sought to determine the influence of hospital factors, in particular familiarity with urolithiasis, on likelihood of decompression for such patients.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Risk Assessment of Stone Formation in Stapled Orthotopic Ileal Neobladder

The increasing trend in performing radical cystectomy (RC) with a minimally invasive approach made stapled neobladders an attractive alternative to hand-sewn pouches. To date, data about the incidence and clinical impact of stone formation in long-surviving neobladder patients are scarce. The aim of this study was to report a long-term, single-center experience of stapled orthotopic ileal neobladder (OIN) and to identify predictors of stone formation.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Physical activity, energy intake, and the risk of incident kidney stones

Recent data suggest higher physical activity (PA) and lower energy intake (EI) may be associated with a lower risk of kidney stones. Whether these associations can be reproduced in other study populations after accounting for lifestyle and dietary factors is not known.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Synergistic Anti-Tumor Effect of Triptolide and Cisplatin in Cisplatin Resistant Human Bladder Cancer Cells

To examine the synergistic anti-tumor effects of cisplatin combined with triptolide (TPL) in cisplatin resistant bladder cancer cells (T24R2) and investigate the possible molecular mechanisms.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Contemporary Surgical Trends in the Management of Upper Tract Calculi

Upper tract nephrolithiasis is a common surgical condition and is treated with multiple surgical techniques including shock wave lithotripsy (SWL), ureteroscopy (URS) and percutaneous nephrolithotomy (PCNL). We analyzed case logs submitted to the American Board of Urology by candidates for initial certification and recertification to help elucidate the trends in management of upper tract urinary calculi.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Selective inhibitory effect of imidafenacin and 5-hydroxymethyl tolterodine on capsaicin-sensitive C-fibers of the primary bladder mechanosensitive afferent nerves in the rat

Imidafenacin and fesoterodine are used in the treatment of overactive bladder. Imidafenacin, fesoterodine and its active metabolite 5-hydroxymethyl tolterodine (5-HMT), are muscarinic receptor antagonists. It is believed that these agents act on afferent nerves in addition to the smooth muscle. We investigated the effects of imidafenacin and 5-HMT on single-unit afferent activities (SAAs) of the mechanosensitive capsaicin (CAP) sensitive and insensitive primary bladder afferent nerve fibers in rats.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Comprehensive Review of Pediatric Urachal Anomalies and Predictive Analysis for Adult Urachal Adenocarcinoma Development

To examine the presentation, diagnosis and management of radiologically diagnosed pediatric urachal anomalies and assess the risk of malignant degeneration.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Impact of dynamic transrectal ultrasonography on pelvic organ prolapse

We hereby developed a new method to evaluate POP dynamically in supine and standing position using transrectal ultrasonography (TRUS). The aim of this study is to visualize descending and prolapsing of pelvic organs in real-time using dynamic TRUS. And, the obtained findings of dynamic TRUS were compared with intraoperative findings.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

An European Multicenter Randomized Noninferiority Trial Comparing 180-W GreenLight-XPS Laser Vaporization and Transurethral Resection of the Prostate for the Treatment of Benign Prostatic Obstruction: 12-Months Results of the GOLIATH-study

We present the one year results of the GOLIATH prospective randomized control trial comparing TURP to GreenLight-XPS (GL-XPS) for the treatment of men with non-neurogenic lower urinary tract symptoms due to prostate enlargement. The updated results at one year show that TURP and GL-XPS remain equivalent and confirm therapeutic durability of both procedures. We also report one-year follow up data from several functional questionnaires (OABq-SF, ICIQ-SF and IIEF) and objective assessments.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Poor Glycemic Control is Associated with Reduced Prostate-Specific Antigen Concentrations in Men with Type 1 Diabetes

Previous studies have demonstrated lower prostate-specific antigen (PSA) concentrations in men with type 2 diabetes (T2DM), paralleling the reported lower prevalence of prostate cancer among diabetic men. Data on PSA in men with type 1 diabetes (T1DM), in whom insulin and obesity profiles differ from those in T2DM, are lacking. The objective of this study was to examine the relationship between long-term glycemic control and PSA in men with T1DM.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Too Frail for Surgery? Initial Results of a Large Multidisciplinary Prospective Study Examining Preoperative Variables Predictive of Poor Surgical Outcomes

M. Revenig, D. J. Canter, M. D. Taylor, C. Tai, J. F. Sweeney, J. M. Sarmiento, D. A. Kooby, S. K. Maithel, V. A. Master and K. Ogan

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Falling Short: Causes and Implications of Drug Shortages in the United States

Since 2001 the number of new or ongoing drug shortages has increased, creating a crisis in the United States. According to the University of Utah Drug Information Service which tracks these data, there were 305 drug shortages in the first quarter of 2014 compared to only 152 in 2010.1 This crisis has now caught the attention of urologists confronting dwindling supplies of bacillus Calmette-Guérin (BCG) as we try to cure or prevent progression of bladder cancer. What makes the lack of BCG of particular concern is that alternatives such as mitomycin C are less effective or scarce.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Erythropoietin accelerates the regeneration of ureteral function in a murine model of obstructive uropathy

Unilateral ureteral obstruction (UUO) halts ureteral peristalsis and may cause pain and lead to infection. The ability of the ureter to recover following removal of the obstruction remains unclear. Erythropoietin (EPO) has been shown to have protective effects in non-hematopoietic organs and to restore peristalsis in hypocontractile intestinal smooth muscle (SM) cells. This study investigated the role of EPO in ureteral SM function and its therapeutic value in UUO.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Utility of Biomarkers in the Prediction of Oncological Outcome after Radical Cystectomy for Squamous Cell Carcinoma

and objectives: We evaluated the association of multiple biomarkers with clinical outcomes in patients treated with radical cystectomy (RC) for squamous cell carcinoma (SCC) of the bladder to identify the best prognostic panel of markers.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Intravesical Bacillus Calmette-Guerin (BCG) efficiently reduces p70S6K1 but not 4E-BP1 phosphorylation in non-muscle invasive bladder cancer (NMIBC)

To characterize the functional consequences, never reported to date, of intravesical BCG on the molecular mechanism of the AKT/mTOR signaling pathway in NMIBC.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Testosterone Recovery after Poly-Trauma and Scrotal Injury in Patients from Operation Enduring Freedom and Operation Iraqi Freedom

We examined the long term natural history of testosterone recovery in patients with complex battle injuries.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Intralesional Injection of Mitomycin C at the Time of Transurethral Incision of Bladder Neck Contracture May Offer Limited Benefit: From the TURNS Study Group

and Objective: Injection of mitomycin C (MMC) may increase the success of transurethral incision of the bladder neck (TUIBN) for the treatment of bladder neck contracture (BNC). Our aim was to evaluate the efficacy of MMC injection across multiple institutions.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Long-Term Followup of Children with Nocturnal Enuresis: Increased Frequency of Nocturia in Adulthood

Goessaert et al are the first to perform a large study on the prevalence of nocturia in young adults with a history of nocturnal enuresis (NE), filling a knowledge gap. They invited patients who had been treated at Ghent University Hospital (departments of urology and nephrology) 5 years or more prior.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

There are similarities between first line management of OAB and IC/BPS, eg patient education, behavioral and dietary modification, fluid management and physical therapy (references 2 and 12 in article). However, the specifics may differ. For example, the goal of physical therapy for OAB is to strengthen the pelvic muscle. In contrast, the goals of physical therapy for IC/BPS are to relax the hypertonic levator muscle, restore normal muscle length and treat specific trigger points.1 Making this distinction is critical when referring patients to the proper physical therapist.

The Journal of Urology (2014)

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Editorial Comment

This study demonstrates that index patients with OAB or IC are easily distinguished. Those with OAB tend to be older and have little or no pain and those with IC tend to be younger and have predominantly pain/discomfort/pressure. Figure 1 shows that these 2 cohorts occupy largely separate domains.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Efficacy of Antibiotic Prophylaxis in Children with Vesicoureteral Reflux: Systematic Review and Meta-Analysis

Controversy exists between the choice of continuous antibiotic prophylaxis (CAP) or observation in the management of children with vesico-ureteral reflux (VUR). Published effectiveness of CAP in children with VUR varies widely. Our objective was to determine whether the aggregated evidence supports the use of CAP in children with VUR.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Use of PDE5-inhibitors may adversely impact biochemical recurrence following radical prostatectomy

Experimental evidence suggests that phosphodiesterase type 5 inhibitors (PDE5i) may suppress tumor growth, postpone metastasis, and prolong survival, but clinical data are lacking. We studied the effect of PDE5i on biochemical recurrence (BCR) after radical prostatectomy for prostate cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Association of Peripheral Microvascular Dysfunction and Erectile Dysfunction

Increasing evidence of a link between erectile dysfunction (ED) and cardiovascular disease (CVD) suggests a shared vascular etiology with endothelial dysfunction as a plausible underlying biological mechanism. Whether this association is different for large arterial compared to microvascular endothelium has yet to be established. The objective of this study was to investigate the association of ED with macrovascular and microvascular endothelial function.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Overuse of Antimicrobial Prophylaxis in Community Practice Urology

We examined index urologic surgeries to assess utilization patterns for antimicrobial prophylaxis in a large community-based population.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Bullying and lower urinary tract symptoms: why the pediatric urologist should care about school bullying

Bullying has become a social plague associated with various deleterious outcomes. We hypothesized that pediatric lower urinary tract symptoms (LUTS) would be associated with bullying exposure.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Increasing use of observation among men at low risk for prostate cancer mortality

There are growing concerns regarding the overtreatment of localized prostate cancer. It is also relatively unknown whether there has been increased uptake of observational strategies for disease management. We assessed the temporal trend in use of observation for clinically localized prostate cancer, particularly among men with low-risk disease, who were young and healthy enough to undergo treatment.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Practice Patterns and Individual Variability of Surgeons Performing Radical Prostatectomies at a High Volume Academic Center

Regional and local variation in radical prostatectomy (RP) rates contribute to overtreatment of low-risk (LR) prostate cancer. We hypothesized individual practice variability would be minimal between urologists practicing in a high-volume academic center.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

Goonewardene et al report the results of a prostate cancer survivorship questionnaire. A proportion of patients requested advice on physical fitness, treatment side effects, emotional concerns, etc. These patients were happy to receive this information in a community based setting and to have a patient support center involved in their care. This is an important finding, considering the results of 2 recent systematic reviews on the potential for exercise interventions to improve quality of life in patients with prostate cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

It is somewhat presumptive to state that the 313 cases with a negative MRI in which clinically significant prostate cancer was missed are failures of MRI/TRUS fusion technology. Two issues to be addressed, namely the aim and design of the study, and the proportion of supposed failures representing clinically significant prostate cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The goal of PCa diagnostics is to find tumors that pose a real risk to life while minimizing the testing required to do so. MRI fusion technology has the potential to improve the detection rate over that of standard 12-core biopsy but whether MRI fusion is a truly beneficial adjunct worth its time and cost is under intense investigation. The current study is significant in that it asks not only whether MRI fusion finds more significant cancers than standard biopsies (it does) but whether PSA cutoffs can be used to help determine which men would most benefit from MRI fusion targeted biopsies.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

Biopsy proven PCa, including high grade cancer, is not rare in men with PSA less than 4.0 ng/ml.1 Under diagnosis of high risk cancer even with low PSA has inspired exploration for a cancer specific biomarker, risk calculators and novel imaging to visualize clinically significant cancer and guide precise targeted biopsy with sampling error reduced by random systematic biopsy.2 A MRI suspicion score was developed and MRI lesion targeted biopsy appears to increase detection rates of clinically significant cancer according to the higher MRI suspicion score.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Improving Detection of Clinically Significant Prostate Cancer: Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Guided Prostate Biopsy

We read with interest the article on magnetic resonance imaging (MRI)/transrectal ultrasound (TRUS) fusion guided prostate biopsy, where the authors demonstrated a better detection rate of clinically significant cancer using fusion biopsy compared to the standard 12-core biopsy technique. We would like the authors to clarify a few points.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Impact of Androgen Deprivation Therapy on Mental and Emotional Well-Being in Men with Prostate Cancer: Analysis from the CaPSURE™ Registry

We were pleased to read the article by Cary et al with a focus on mental and emotional issues in patients on androgen deprivation therapy. Each year more than 40,000 men in the United Kingdom are diagnosed with prostate cancer (more than 100 men per day), and the disease is predicted to become the most common cancer overall by 2030.1 These patients are deemed “survivors.” Specific aspects of cancer survivorship, eg lifestyle changes, still need to be addressed.2 Needless to say, the volumes of these patients are vast.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Ultrasound Guided Transversus Abdominis Plane vs Surgeon Administered Intraoperative Regional Field Infiltration with Bupivacaine for Early Postoperative Pain Control in Children Undergoing Open Pyeloplasty

Prospective, randomized, controlled studies are difficult to conduct and even more so when pediatric patients are involved. This recent study by Lorenzo et al was ambitious, and their efforts should be commended. There are relatively few pediatric transversus abdominis plane (TAP) studies, and we had hoped that this series would help guide our practice. However, after reviewing the methodology used it was not surprising that the authors found local infiltration superior to TAP blocks for pain relief following open pyeloplasty.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Systematic Review and Meta-Analysis of Perioperative and Oncologic Outcomes of Laparoscopic Cryoablation versus Laparoscopic Partial Nephrectomy for the Treatment of Small Renal Tumors

The authors of this meta-analysis comparing laparoscopic renal cryoablation (LRC) and partial nephrectomy (PN) concluded that oncologic outcomes following LRC were substantially worse than those following PN. They should be congratulated for their efforts in comparing oncologic outcomes between these 2 surgical techniques for the management of small renal masses. However, some characteristics of the series evaluated in the meta-analysis deserve discussion.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Salvage Lymph Node Dissection for nodal recurrence of prostate cancer after Radical Prostatectomy

We analyzed the impact of salvage lymph node dissection (sLND) on prognosis of patients with biochemical recurrence (BCR) and positive LN in positron emission tomography/computed tomography (PET/CT) scan after radical prostatectomy (RP).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Systemic Atherosclerosis Causes Detrusor Overactivity: Functional and Morphological Changes in Hyperlipoproteinemic apoELDLR Mice

The prevalence of systemic atherosclerosis and overactive bladder/detrusor overactivity increases almost simultaneously with age but an association between these diseases has not yet been proved. We evaluated changes in bladder function and morphology, including vascularization, in apoE–/–LDLR–/– double knockout mice with systemic atherosclerosis but without central nervous system involvement.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Association of Moderate to Severe Lower Urinary Tract Symptoms with Incident Type 2 Diabetes and Heart Disease

Increasing evidence suggest a possible link between lower urinary tract symptoms (LUTS) and chronic illnesses. The objective of this study was to determine whether LUTS are associated with incident type 2 diabetes (T2D) and heart disease (HD) in a population-based.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Outcomes of endoscopic incision for the treatment of ureteroceles at a single institution

We assessed outcomes of children with ureterocele after transurethral incision (TUI) at our institution from 2001 to 2014, focusing on endpoints of vesicoureteral reflux (VUR), improvement of hydronephrosis, and need for second surgery.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Novel Bladder Preservation Therapy, OMC-Regimen: Combined Therapy using Balloon-Occluded Arterial Infusion of Anticancer Agent and Hemodialysis with Concurrent Radiation

We investigated the effect of balloon-occluded arterial infusion (BOAI) of an anticancer agent (cisplatin/gemcitabine), used concomitantly with hemodialysis, which delivers an extremely high concentration of anticancer agent to the site of a tumor without systemic adverse effects, along with concurrent radiation (referred to as the “OMC-regimen”) in patients with advanced bladder cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Estrogen receptor-alpha is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia

While estrogens are important in prostate growth and play a role in benign prostatic hyperplasia (BPH), no current therapies directly target estrogen action. Estrogens act primarily via estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). Using a mouse model, we evaluated the relative contribution of these receptors to bladder complications of BPH. We also evaluated prevention of these bladder complications by selective estrogen receptor modulators (SERMs), raloxifene and tamoxifen (ERα selective antagonists) and (R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol (R,R-THC, ERβ selective antagonist).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Characteristics and survival of end stage renal disease (ESRD) patients with spina bifida in the United States Renal Data System (USRDS)

We described the characteristics, treatments, and survival of persons with spina bifida (SB) who developed end stage renal disease (ESRD) from 2004 through 2008 in the United States Renal Data System (USRDS).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

Our study was intended to represent the real practice of pediatric urologists. We agree that in an ideal research world VCUG would be repeated every year for 5 years. However, this imaging study is not without risks (UTI, urethral trauma, irradiation and secondary malignancies) and can be quite difficult for the young child. We also make efforts to apply the ALARA principle and to reduce urethral manipulations in our patients. We believe that VCUG should be performed only in cases involving recurrent UTIs after injection or recurrent symptoms.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

We have learned from other studies that a followup of 3 months is woefully inadequate.1 Had the study been designed prospectively, delayed VCUG could have addressed the important question of superior persistence of one of the products over the other.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Role of EGFR Family Inhibitors in Muscle Invasive Bladder Cancer: A Review of Clinical Data and Molecular Evidence

Conventional platinum based chemotherapy for advanced urothelial carcinoma is plagued by common resistance to this regimen. Several studies implicate the EGFR family of RTKs in urothelial carcinoma progression and chemoresistance. Many groups have investigated the effects of inhibitors of this family in patients with urothelial carcinoma. This review focuses on the underlying molecular pathways that lead to urothelial carcinoma resistance to EGFR family inhibitors.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Thromboembolic Complications in 3,544 Patients Undergoing Radical Prostatectomy with or without Lymph Node Dissection

Lymph node dissection in patients with prostate cancer may increase complications. An association of lymph node dissection with thromboembolic events was suggested. We compared the incidence and investigated predictors of deep venous thrombosis and pulmonary embolism among other complications in patients who did or did not undergo lymph node dissection during open and robot-assisted laparoscopic radical prostatectomy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The artificial somato-autonomic reflex arch does not improve lower urinary tract function in patients with spinal cord lesions

The artificial somato-autonomic reflex arch (Xiao procedure) has been proposed as a treatment modality for neurogenic bladder dysfunction. We aimed at investigating the effects of the procedure on lower urinary tract function.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

5-Year Longitudinal Follow-up after Retropubic and Transobturator Midurethral Slings

Few studies have characterized longer-term outcomes after retropubic and transobturator midurethral slings.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Comparison of Long-Term Efficacy of Desmopressin Lyophilisate and Enuretic Alarm for Monosymptomatic Enuresis and Assessment of Predictive Factors for Success: A Randomized Prospective Trial

We aimed to compare long-term success of desmopressin lyophilisate (DESM-melt) and enuretic alarm (EA) in primary monosymptomatic nocturnal enuresis (PMNE), and to determine predictive factors for success.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Intraoperative Registered Transrectal Ultrasound Guidance for Robot-Assisted Laparoscopic Radical Prostatectomy

To provide unencumbered real-time ultrasound image guidance during robot-assisted laparoscopic radical prostatectomy, we developed a robotic transrectal ultrasound system that tracks the da Vinci® Surgical System instruments. We describe our initial clinical experience with this system.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Human papillomavirus prevalence in invasive penile cancer and association with clinical outcome

Penile cancer incidence is rising and suggested to be explained by changes in sexual practice and increased exposure of males to sexually transmitted high-risk human papillomavirus (hrHPV) infection. Previously, we found in penile cancers from a Dutch population treated in the years 1963-2001, a hrHPV prevalence of about 30%. Here, we assessed the prevalence of hrHPV-DNA in a more recent, contemporary penile cancer cohort and association with patient survival.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Cross-sectional and Longitudinal Associations of Sexual Function with Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia

To examine the cross-sectional associations between baseline characteristics and sexual function and the longitudinal associations between change in lower urinary tract symptoms (LUTS) and change in sexual function among men with benign prostatic hyperplasia (BPH).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Venous thromboembolism following radical cystectomy: significant predictors, comparison of different anticoagulants, and timing of events

To determine the rate, timing, and predictors of venous thromboembolism (VTE) following open radical cystectomy for urothelial bladder cancer (UBC) and compare warfarin (1971-2008) vs. unfractionated heparin (2008-2012) use as prophylaxis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Predictive value of Magnetic Resonance Imaging Determined Tumor Contact Length for Extra-capsular Extension of Prostate cancer

Tumor contact length (TCL) is defined as the amount of prostate cancer in contact with the prostatic capsule. Comparing to existing predictors of extra-capsular extension (ECE), we evaluated the ability of MRI-determined TCL to predict microscopic ECE.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Role of Image-Guided Biopsy Targeting in Patients with Atypical Small Acinar Proliferation

Men diagnosed with atypical small acinar proliferation (ASAP) are counseled to undergo early re-biopsy, as their risk of prostate cancer (PCa) is high. However, random re-biopsies may not re-sample areas of concern. Magnetic resonance imaging/transrectal ultrasound (MRI/TRUS) fusion-guided biopsy offers an opportunity to accurately target, and later re-target, specific areas within the prostate. The purpose of this study is to describe the ability of MRI/TRUS fusion-guided prostate biopsy to detect PCa in areas with an initial diagnosis of ASAP.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Salvage Lymph Node Dissection for Prostate Cancer Nodal Recurrence Detected by C-Choline Positron Emission Tomography/Computerized Tomography

We report salvage lymph node dissections for prostate cancer nodal recurrence detected by 11C-choline positron emission tomography/computerized tomography in the setting of increasing prostate specific antigen after radical prostatectomy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Rates of Teratoma and Viable Cancer at Post-Chemotherapy Retroperitoneal Lymph Node Dissection after Induction Chemotherapy for Good Risk Non-Seminomatous Germ Cell Tumors

Patients with good risk nonseminomatous germ cell tumors receive induction chemotherapy with either 4 cycles of etoposide and platinum (EPx4) or three cycles of bleomycin, etoposide, and platinum (BEPx3). We report the histologic results at post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) after induction chemotherapy in patients treated either with EP or BEP for good risk NSGCT.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Transobturator Versus Retropubic Approach for a Mid Urethral Sling

I prefer the transobturator (TO) mid urethral sling because it has similar efficacy, fewer operative complications, and fewer postoperative obstructive voiding and urgency symptoms than the retropubic (RP) mid urethral sling. However, there are several potential problems with any sling, including intraoperative complications, lack of efficacy (the sling is not tight enough), the sling is too tight causing obstructive voiding symptoms and persistent or new bothersome urgency symptoms.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Seventeen Years’ Follow-up of the Tension-Free Vaginal Tape Procedure for Female Stress Urinary Incontinence

C. G. Nilsson, K. Palva, R. Aarnio, E. Morcos and C. Falconer

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Effect of Pelvic Organ Prolapse Severity on Improvement in Overactive Bladder Symptoms after Pelvic Reconstructive Surgery

J. M. Miranne, V. Lopes, C. L. Carberry and V. W. Sung

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Case for Robotics in Pelvic Prolapse Surgery

R. Morris, S. Mock and R. Dmochowski

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Changes in Tissue Composition of the Vaginal Wall of Premenopausal Women with Prolapse

M. H. Kerkhof, A. M. Ruiz-Zapata, H. Bril, M. C. Bleeker, J. A. Belien, R. Stoop and M. N. Helder

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: A Critical Evaluation of Salivary Testosterone as a Method for the Assessment of Serum Testosterone

T. Fiers, J. Delanghe, G. T’Sjoen, E. Van Caenegem, K. Wierckx and J. M. Kaufman

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Predictors of Sexual Dysfunction Incidence and Remission in Men

S. A. Martin, E. Atlantis, K. Lange, A. W. Taylor, P. O’Loughlin and G. A. Wittert; Florey Adelaide Male Ageing Study

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Preoperative Erectile Function is the Only Predictor of the Use of a High Number of Phosphodiesterase Type-5 Inhibitors after Bilateral Nerve-Sparing Radical Prostatectomy

G. Gandaglia, A. Gallina, N. Suardi, F. Abdollah, N. Passoni, M. Bianchi, E. Zaffuto, A. Nini, D. Vizziello, A. Salonia, F. Montorsi and A. Briganti

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparison of the Effect of Sertraline with Behavioral Therapy on Semen Parameters in Men with Primary Premature Ejaculation

G. Akasheh, L. Sirati, A. R. Noshad Kamran and Z. Sepehrmanesh

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Prevalence of Human Papillomaviruses in Semen: A Systematic Review and Meta-Analysis

C. Laprise, H. Trottier, P. Monnier, F. Coutlée and M. H. Mayrand

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparative Analysis of Three Sperm DNA Damage Assays and Sperm Nuclear Protein Content in Couples Undergoing Assisted Reproduction Treatment

L. Simon, L. Liu, K. Murphy, S. Ge, J. Hotaling, K. I. Aston, B. Emery and D. T. Carrell

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Association between DAZL Polymorphisms and Susceptibility to Male Infertility: Systematic Review with Meta-Analysis and Trial Sequential Analysis

S. Zhang, Q. Tang, W. Wu, B. Yuan, C. Lu, Y. Xia, H. Ding, L. Hu, D. Chen, J. Sha and X. Wang

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Lower Urinary Tract Symptoms Improve with Testosterone Replacement Therapy in Men with Late-Onset Hypogonadism: 5-Year Prospective, Observational and Longitudinal Registry Study

D. J. Yassin, Y. El Douaihy, A. A. Yassin, J. Kashanian, R. Shabsigh and P. G. Hammerer

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Lower Urinary Tract Symptoms Improve with Testosterone Replacement Therapy in Men with Late-Onset Hypogonadism: 5-Year Prospective, Observational and Longitudinal Registry Study

D. J. Yassin, Y. El Douaihy, A. A. Yassin, J. Kashanian, R. Shabsigh and P. G. Hammerer

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Risks and Benefits of Bladder Antimuscarinics among Elderly Residents of Veterans Affairs Community Living Centers

D. C. Moga, R. M. Carnahan, B. C. Lund, J. F. Pendergast, R. B. Wallace, J. C. Torner, Y. Li and E. A. Chrischilles

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Efficacy of Adding Behavioural Treatment or Antimuscarinic Drug Therapy to α-Blocker Therapy in Men with Nocturia

T. M. Johnson, II, A. D. Markland, P. S. Goode, C. P. Vaughan, J. L. Colli, J. G. Ouslander, D. T. Redden, G. McGwin and K. L. Burgio

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Long-Term Follow-up after Transurethral Treatment of Infravesical Obstruction in Boys

J. H. Kieft, P. M. Hennus, E. Hoenjet, S. P. Rynja, T. P. De Jong, J. L. Bosch and L. M. De Kort

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Late Ureteral Obstruction after Injection of Dextranomer/Hyaluronic Acid Copolymer

S. Christen, M. Mendoza, R. Gobet, P. Bode and D. Weber

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Margin Status and Tumor Recurrence after Nephron-Sparing Surgery for Bilateral Wilms Tumor

K. Kieran, M. A. Williams, J. S. Dome, L. M. McGregor, M. J. Krasin and A. M. Davidoff

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Outcomes of Observation as Therapy for Pelvic Organ Prolapse: A Study in the Natural History of Pelvic Organ Prolapse

A. S. Gilchrist, W. Campbell, H. Steele, H. Brazell, J. Foote and S. Swift

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Outcomes of Retroperitoneal Lymph Node Dissection for the Most Challenging Cases

Testis cancer is the most common solid organ malignancy in men 15 to 34 years old, but after appropriate treatment more than 90% of patients are cured.1 Even of those with advanced disease requiring chemotherapy 70% to 80% achieve long-term remission.1 The success in the management of testis cancer is unparalleled in urology, largely due to the seamless integration and coordination between medical oncologists and urological cancer surgeons. For other urological malignancies similar coordination and success have yet to be achieved.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Tadalafil for Prevention of Erectile Dysfunction after Radiotherapy for Prostate Cancer: The Radiation Therapy Oncology Group [0831] Randomized Clinical Trial

T. M. Pisansky, S. L. Pugh, R. E. Greenberg, N. Pervez, D. R. Reed, S. A. Rosenthal, R. B. Mowat, A. Raben, M. K. Buyyounouski, L. A. Kachnic and D. W. Bruner

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Alcohol and Male Reproductive Health: A Cross-Sectional Study of 8344 Healthy Men from Europe and the USA

T. K. Jensen, S. Swan, N. Jørgensen, J. Toppari, B. Redmon, M. Punab, E. Z. Drobnis, T. B. Haugen, B. Zilaitiene, A. E. Sparks, D. S. Irvine, C. Wang, P. Jouannet, C. Brazil, U. Paasch, A. Salzbrunn, N. E. Skakkebæk and A. M. Andersson

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Operating Characteristics of Follicle-Stimulating Hormone in Azoospermic Men

M. S. Christman, S. R. Gudeman, J. J. Nork, R. C. Walters, J. O. L’Esperance and D. S. Crain

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

News and Announcements

President – Dr. William W. Bohnert, 3500 E. Lincoln Drive, Lot #33, Phoenix, Arizona 85018

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Epigenetic Factors Affect Tumor Initiation, Progression and Recurrence

We are witnessing a major paradigm shift in the way that we diagnose and treat cancer. Therapies designed in the 20th century were predominantly agents that caused indiscriminate genomic damage or cellular stress, whereas an emerging understanding of tumor genetics and biology has redirected our efforts toward targeting the pathophysiology of individual tumors. This has been facilitated by exponential advances in sequencing technology. The first fully sequenced eukaryote genome, Saccharomyces cerevisiae (12.1 Mb), was celebrated in 1996,1 followed in 2003 by the first full human genome, a massive international collaborative effort spanning more than a decade.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply by Authors

As the first procedure of its kind, our technique of robotic autotransplantation will likely evolve. Input from expert robotic and transplant surgeons such as this and contributions from those who embark on robotic renal autotransplantation in the future will certainly lead to improvements in the procedure. We share enthusiasm for the GelPort to introduce harvested kidneys for robotic allogeneic transplantation. In contrast to requiring an incision to introduce a donor kidney through a GelPort, the difference in robotic autotransplantation is the benefit of never having to extract the kidney being autotransplanted.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

Renal autotransplantation has remained underused due to the need for 2 major interventions (donor nephrectomy and transplantation) and perhaps to a lack of training in transplantation for many urologists. Robotic technique as described or with some modifications has potential in patients with complex ureteral loss.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Between a Rock and a Hard Place: Getting Families to Change Behaviors to Reduce Pediatric Stone Disease Recurrence

The rapidly increasing incidence of stones in adults and children during the last 25 years is consistent with the effects of our rapidly changing lifestyle during the last 25 years. The good news is that lifestyles can be changed. The bad news is that changing lifestyles is difficult and documentation that changing lifestyles makes a difference in stone recurrence in children is largely lacking. Even the rate of stone recurrence is not known in children.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Urodynamic Effects of the Combination of Tamsulosin and Daily Tadalafil in Men with Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Randomized, Placebo-Controlled Clinical Trial

R. P. Regadas, R. Reges, J. B. G. Cerqueira, D. G. Sucupira, I. R. Josino, E. A. Nogueira, F. V. F. Jamacaru, M. O. de Moraes, and L. F. G. Silva

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Complications of Stone Disease in the 21st Century—Can Noninvasive and Minimally Invasive Treatment Modalities Improve the Overall Renal Health of Stone Formers?

When extracorporeal shock wave lithotripsy (SWL) was first used clinically at the University of Munich in 1982, its safety and efficacy in the noninvasive fragmentation of kidney and ureteral stones were demonstrated in short order.1 As a result, 17 lithotripsy machines were strategically distributed to urology departments throughout Germany starting in 1983. The initiative to provide nationwide access to this minimally invasive treatment technology for stone patients was financed jointly by the Kuratorium für Heimdialyse (a national organization for home dialysis) and the German health care system.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Home Study Course 2014 Volume 191/192

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Ambulatory Blood Pressure Monitoring in Children with Vesicoureteral Reflux

S. Yavuz, A. Anarat and A. K. Bayazit

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Investigative Urology

Maldonado et al (page 1542) from Baltimore, Maryland evaluated promoter methylation of genes previously reported as aberrantly methylated in prostate cancer (PCa) by quantitative fluorogenic methylation-specific polymerase chain reaction using cancer tissue from a nested case-control study of patients surgically treated for prostate cancer.1 Recurrent cases and controls were compared and the association between methylation and recurrence risk was estimated. GSTP1 methylation was greater in patients with recurrence than in controls, especially patients with early organ confined disease or limited extraprostatic extension.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Single-fraction radiosurgery for the treatment of renal tumors

High-dose local stereotactic radiosurgery (SRS) has been performed in selected patients to improve local tumor control and overall survival. Here we report on patients with renal tumors who were treated with single-fraction robotic SRS.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The cistrome and gene signature of androgen receptor splice variants in castration-resistant prostate cancer cells

Spliced variant forms of androgen receptor (AR-Vs) have been identified recently in castration-resistant prostate cancer (CRPC) cell lines and clinical samples. We identified the cistrome and gene signature of AR-Vs in CRPC cell lines and determined the clinical significance of AR-Vs regulated genes.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Increased Brain Gray Matter in the Primary Somatosensory Cortex is Associated with Increased Pain and Mood Disturbance in Interstitial Cystitis/Painful Bladder Syndrome Patients

Interstitial cystitis (IC) is a highly prevalent pain condition, estimated to affect 3-6% of women in the United States. Emerging data suggests there are central neurobiological components to the etiology of this disease. Here we report the first brain structural imaging findings from the Multidisciplinary Approach to Pelvic Pain (MAPP) network, with data on over 300 participants.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Neoadjuvant Chemotherapy Improves Survival of Patients with Upper Tract Urothelial Carcinoma

S. Porten, A. O. Siefker-Radtke, L. Xiao, V. Margulis, A. M. Kamat, C. G. Wood, E. Jonasch, C. P. Dinney and S. F. Matin

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Randomized Controlled Trial of Expressive Writing for Patients with Renal Cell Carcinoma

K. Milbury, A. Spelman, C. Wood, S. F. Matin, N. Tannir, E. Jonasch, L. Pisters, Q. Wei and L. Cohen

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Phosphodiesterase 5 Inhibitors Enhance Chemotherapy Killing in Gastrointestinal/Genitourinary Cancer Cells

L. Booth, J. L. Roberts, N. Cruickshanks, A. Conley, D. E. Durrant, A. Das, P. B. Fisher, R. C. Kukreja, S. Grant, A. Poklepovic and P. Dent

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Survivin-Induced Abnormal Ploidy Contributes to Cystic Kidney and Aneurysm Formation

W. A. Aboualaiwi, B. S. Muntean, S. Ratnam, B. Joe, L. Liu, R. L. Booth, I. Rodriguez, B. S. Herbert, R. L. Bacallao, M. Fruttiger, T. W. Mak, J. Zhou and S. M. Nauli

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Physicians’ Attitudes about Multiplex Tumor Genomic Testing

S. W. Gray, K. Hicks-Courant, A. Cronin, B. J. Rollins and J. C. Weeks

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Effectiveness of Primary Androgen-Deprivation Therapy for Clinically Localized Prostate Cancer

A. L. Potosky, R. Haque, A. E. Cassidy-Bushrow, M. Ulcickas Yood, M. Jiang, H. T. Tsai, G. Luta, N. L. Keating, M. R. Smith and S. K. Van Den Eeden

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Effect of Insurance Expansion on Utilization of Inpatient Surgery

C. Ellimoottil, S. Miller, J. Z. Ayanian and D. C. Miller

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparative Effectiveness of Robot-Assisted and Open Radical Prostatectomy in the Postdissemination Era

G. Gandaglia, J. D. Sammon, S. L. Chang, T. K. Choueiri, J. C. Hu, P. I. Karakiewicz, A. S. Kibel, S. P. Kim, R. Konijeti, F. Montorsi, P. L. Nguyen, S. Sukumar, M. Menon, M. Sun and Q. D. Trinh

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Indications for Intervention during Active Surveillance of Prostate Cancer: A Comparison of the Johns Hopkins and Prostate Cancer Research International Active Surveillance (PRIAS) Protocols

M. Kates, J. J. Tosoian, B. J. Trock, Z. Feng, H. B. Carter and A. W. Partin

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Enzalutamide in Metastatic Prostate Cancer before Chemotherapy

T. M. Beer, A. J. Armstrong, D. E. Rathkopf, Y. Loriot, C. N. Sternberg, C. S. Higano, P. Iversen, S. Bhattacharya, J. Carles, S. Chowdhury, I. D. Davis, J. S. de Bono, C. P. Evans, K. Fizazi, A. M. Joshua, C. S. Kim, G. Kimura, P. Mainwaring, H. Mansbach, K. Miller, S. B. Noonberg, F. Perabo, D. Phung, F. Saad, H. I. Scher, M. E. Taplin, P. M. Venner and B. Tombal; PREVAIL Investigators

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Metastases in Normal-Sized Pelvic Lymph Nodes: Detection with Diffusion-Weighted MR Imaging

H. C. Thoeny, J. M. Froehlich, M. Triantafyllou, J. Huesler, L. J. Bains, P. Vermathen, A. Fleischmann and U. E. Studer

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Distal Hypospadias Repair Using Only Glans Wing Mobilization and Approximation

J. M. Lacy, L. N. Hendrix, C. Grant and A. M. Ziada

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Novel Management Approach to Connecting Tube Erosion of Artificial Urinary Sphincter

A. A. Boateng, M. A. Mohamed and A. E. Mahdy

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Hemostatic Matrix during Corporotomy Closure

S. D. Cohen and J. F. Eid

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Single Center Outcomes after Reconstructive Surgical Correction of Adult Acquired Buried Penis: Measurements of Erectile Function, Depression, and Quality of Life

J. Rybak, S. Larsen, M. Yu and L. A. Levine

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: National Trends in the Treatment of Penile Prosthesis Infections by Explantation Alone vs. Immediate Salvage and Reimplantation

S. Zargaroff, V. Sharma, D. Berhanu, J. A. Pearl, J. J. Meeks, J. M. Dupree, B. V. Le, J. Cashy and K. T. McVary

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Penile Prosthesis Implantation in Acute and Chronic Priapism

G. Garaffa and D. J. Ralph

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Efficacy and Safety of Tadalafil Monotherapy for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Meta-Analysis

Y. Dong, L. Hao, Z. Shi, G. Wang, Z. Zhang and C. Han

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Effects of Dutasteride and Finasteride on BPH-Related Hospitalization, Surgery and Prostate Cancer Diagnosis: A Record-Linkage Analysis

L. Cindolo, C. Fanizza, M. Romero, L. Pirozzi, R. Autorino, F. Berardinelli and L. Schips

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Efficacy and Safety of the Simultaneous Administration Of Mirodenafil and an α-Blocker in Men with BPH-LUTS: A Multicenter Open-Label Prospective Study

W. J. Bang, C. Y. Oh, C. Yoo, J. S. Cho, D. Y. Yang, D. H. Lee, S. H. Lee and B. H. Chung

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: The Impact of Unplanned Postprocedure Visits in the Management of Patients with Urinary Stones

C. D. Scales, Jr., C. S. Saigal, J. M. Hanley, A. W. Dick, C. M. Setodji and M. S. Litwin; NIDDK Urologic Diseases in America Project

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparative Effectiveness of Shock Wave Lithotripsy and Ureteroscopy for Treating Patients with Kidney Stones

C. D. Scales, Jr., J. C. Lai, A. W. Dick, J. M. Hanley, J. van Meijgaard, C. M. Setodji and C. S. Saigal; Urologic Diseases in America Project

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Incidence of Hypercalciuria and Hypercalcemia during Vitamin D and Calcium Supplementation in Older Women

J. C. Gallagher, L. M. Smith and V. Yalamanchili

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Activity, Energy Intake, Obesity, and the Risk of Incident Kidney Stones in Postmenopausal Women: A Report from the Women’s Health Initiative

M. D. Sorensen, T. Chi, N. M. Shara, H. Wang, R. S. Hsi, T. Orchard, A. J. Kahn, R. D. Jackson, J. Miller, A. P. Reiner and M. L. Stoller

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: In Vivo Predictors of Renal Cyst Pseudoenhancement at 120 kVp

J. Patel, M. S. Davenport, S. Khalatbari, R. H. Cohan, J. H. Ellis and J. F. Platt

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Pyelonephritis: What are the Present Day Causative Organisms and Antibiotic Susceptibilities?

A. Prabhu, P. Taylor, P. Konecny and M. A. Brown

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Escherichia coli Antimicrobial Resistance Increased Faster among Geriatric Outpatients Compared with Adult Outpatients in the USA, 2000-10

G. V. Sanchez, S. J. Adams, A. M. Baird, R. N. Master, R. B. Clark and J. M. Bordon

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Congenital Malformations and Testicular Germ Cell Tumors

B. Trabert, D. Zugna, L. Richiardi, K. A. McGlynn and O. Akre

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Impact of HLA Mismatch at First Kidney Transplant on Lifetime with Graft Function in Young Recipients

B. J. Foster, M. Dahhou, X. Zhang, R. W. Platt, J. M. Smith and J. A. Hanley

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Laparoscopic Radical Prostatectomy Demonstrates Less Morbidity than Open Radical Prostatectomy: An Analysis of the American College of Surgeons-National Surgical Quality Improvement Program Database with a Focus on Surgical Trainee Involvement

R. J. Caras, M. B. Lustik, S. Q. Kern, J. R. Sterbis and L. P. McMann

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Fluorescence-Enhanced Robotic Radical Prostatectomy Using Real-Time Lymphangiography and Tissue Marking with Percutaneous Injection of Unconjugated Indocyanine Green: The Initial Clinical Experience in 50 Patients

T. B. Manny, M. Patel and A. K. Hemal

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: National Multi-Institutional Comparison of 30-Day Postoperative Complication and Readmission Rates between Open Retropubic Radical Prostatectomy and Robot-Assisted Laparoscopic Prostatectomy Using NSQIP

M. A. Pilecki, B. B. McGuire, U. Jain, J. Y. Kim and R. B. Nadler

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Acute Testicular Fracture

An otherwise healthy, 15-year-old boy presented to the emergency department with acute scrotal pain 48 hours after trauma to the scrotum in a wrestling match. He denied nausea, emesis or any voiding difficulties. Urinalysis was negative. Physical examination revealed a tense, tender and ecchymotic left hemiscrotum and normal right hemiscrotum. The left testis was difficult to palpate, and the cremasteric reflex was intact. Scrotal ultrasound showed heterogeneous echogenicity, extruded testicular contents, absence of arterial and venous flow in the lower pole of the left testis compatible with testicular rupture (see figure) as well as a complex left hydrocele.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Identification of Threshold Prostate Specific Antigen Levels to Optimize the Detection of Clinically Significant Prostate Cancer by Magnetic Resonance Imaging/Ultrasound Fusion Guided Biopsy

Prostate specific antigen sensitivity increases with lower threshold values but with a corresponding decrease in specificity. Magnetic resonance imaging/ultrasound targeted biopsy detects prostate cancer more efficiently and at higher grade than standard 12-core transrectal ultrasound biopsy but the optimal population for its use is not well defined. We evaluated the performance of magnetic resonance imaging/ultrasound targeted biopsy vs 12-core biopsy across a prostate specific antigen continuum.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Endometriosis, Endocervicosis and Müllerianosis of the Bladder

Several types of benign müllerian growth can involve the bladder, the most common of which is endometriosis, with histological identification of endometrial glands and stroma.1 The presence of endocervical type glands in the muscularis propria of the bladder is called endocervicosis.2 Finally, fallopian tube type epithelium can rarely be seen in the bladder, in association with endometriosis or endocervicosis, and this mixture is designated as müllerianosis.3,4

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Histological Analysis of the Kidney Tumor-Parenchyma Interface

During enucleative partial nephrectomy (PN), excision is performed adjacent to the tumor edge. To better inform the oncological propriety of enucleative PN, we histologically examined the tumor-parenchyma interface.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Fragmentation of Urinary Calculi in Vitro by Burst Wave Lithotripsy

We developed a new method of lithotripsy that uses short, broadly focused bursts of ultrasound rather than shock waves to fragment stones. We investigated the characteristics of stone comminution by burst wave lithotripsy in vitro.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Fluoroquinolone Resistance in the Rectal Carriage of Men in an Active Surveillance Cohort: Longitudinal Analysis

Rectal swabs can identify men with fluoroquinolone (FQ)-resistant bacteria and reduce rates of infection after transrectal ultrasound guided prostate biopsy (TRUSB) by targeted antimicrobial prophylaxis. We evaluated the rate of FQ resistance in an active surveillance cohort with attention to factors associated with resistance and changes in resistance over time.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Early discontinuation of antibiotic prophylaxis in patients with persistent primary vesicoureteral reflux initially detected during infantile period: Outcome analysis and risk factors for febrile urinary tract infection

To evaluate the incidence of febrile UTI and assessed risk factors for febrile UTI during active surveillance after early discontinuation of continuous antibiotic prophylaxis (CAP), we retrospectively reviewed our experience on active surveillance.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Pediatric Urology

Trauma remains the single highest cause of death and acquired disability in children. Speculation is that susceptibility to renal trauma in children is related to less perirenal fat, smaller abdominal muscles and lack of calcification of the rib cage, thereby providing less protection to the kidneys. Grimsby et al (page 1498) from Dallas, Texas define the epidemiology of renal trauma in the pediatric population throughout the United States by retrospectively reviewing the American College of Surgeons National Trauma Data Bank.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

This Month in Adult Urology

Rahbar et al (page 1337) report on a multi-institutional trial in a large cohort of patients undergoing robotic nephrectomy for a small renal mass, and examined whether following the algorithm would change treatment after biopsy was performed.1 The assumption was that “perfect” biopsies were feasible in all cases and had 100% concordance with the pathological findings. Based on the revised algorithm, grade I clear cells were assigned to the intermediate risk group. Of the patients 51% would have been assigned to treatment and 25% to active surveillance.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Sarcopenia as a Predictor of Complications and Survival Following Radical Cystectomy

This study of the impact of sarcopenia on complications and survival following radical cystectomy is a timely and important article in the burgeoning field of sarcopenia research. The deleterious impacts of sarcopenia on outcomes among patients with cancer are rapidly being acknowledged.1–3 However, as urologists begin to scrutinize the impact of body composition on outcomes in our patients, we must be specific regarding the methods by which lean muscle mass is estimated to ensure consistency. Several issues in this report would benefit from clarification with respect to the measurement of muscle depletion.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Testes in Infants with Prader-Willi Syndrome: Human Chorionic Gonadotropin Treatment, Surgery and Histology

Boys with Prader-Willi syndrome often have undescended testes. Prospective studies on the treatment of cryptorchidism in these patients are lacking. We evaluated the effects of human chorionic gonadotropin administration on testis position in 16 males with Prader-Willi syndrome. In patients who subsequently underwent orchiopexy biopsy was taken and testis histology was evaluated.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Receipt of “Best Care” According to Current Quality of Care Measures and Outcomes Among men with Prostate Cancer

We evaluated whether prostate cancer patients receiving “Best Care” according to a set of five nationally endorsed quality measures had decreased treatment related morbidity and improved cancer control.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Absorption of Irrigation Fluid Occurs Frequently during High Power 532 nm Laser Vaporization of the Prostate

Absorption of irrigation fluid was not detected during GreenLight™ laser vaporization of the prostate using the first generation 80 W laser. However, data are lacking on intraoperative irrigation fluid absorption using the second generation 120 W high power laser. We assessed whether fluid absorption occurs during high power laser vaporization of the prostate.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Development of Hypertension is Less Frequent after Bilateral Nephron Sparing Surgery for Bilateral Wilms Tumor in a Long-Term Survey

The option of nephron sparing surgery for unilateral Wilms tumor has been debated in the recent literature. This procedure is being used increasingly to preserve kidney tissue and function. However, nephron sparing surgery is feasible only for selected cases, and a higher local relapse rate has been observed. Moreover, a significant reduction of nephrons is associated with development of renal hypertension and progressive renal failure. We analyzed outcomes after bilateral partial nephrectomy and unilateral partial plus contralateral total nephrectomy in patients with bilateral Wilms tumor.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

This article addresses the outcomes of children with unilateral VUR and low grade or resolved contralateral reflux undergoing ipsilateral open ureteral reimplantation. In the absence of routine postoperative cystourethrography the authors cannot comment on the strict technical success of the procedure regarding either kidney. Although there were no cases of febrile urinary tract infections postoperatively, the results should be interpreted with caution, given the sample size of only 15 cases. It is possible that the study was under powered to detect the uncommon occurrence of febrile urinary tract infection following reimplantation.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Comment

The authors should be congratulated for performing this large review comparing endoscopic findings of the ureteral orifice to VUR grade and timing of VUR onset. Their key finding is that early onset of VUR during bladder filling on VCUG is associated with a more abnormal ureteral orifice, namely higher hydrodistention grades. The real usefulness of this finding is that it provides further support to stratifying children with any given grade of VUR by the timing of their VUR. The volume at onset, or “timing,” of VUR has previously been observed to be a factor predictive of resolution independent of grade (references 1 and 17 in article).

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

3.5 cm Artificial Urinary Sphincter Cuff Erosion Occurs Predominantly in Radiated Patients

We analyzed our initial 100-case experience using the 3.5 cm artificial urinary sphincter (AUS) cuff to identify risk factors for cuff erosion.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Utility of Transurethral Biopsy for Staging the Prostatic Urethra before Radical Cystectomy

We determined the likelihood that transurethral resection biopsy of the prostatic urethra adjacent to the verumontanum would detect prostatic involvement of urothelial carcinoma in patients with bladder carcinoma.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Radiofrequency ablation versus partial nephrectomy for clinical T1b renal cell carcinoma: long-term clinical and oncologic outcomes

To compare outcomes in patients treated with radiofrequency ablation (RFA) and partial nephrectomy(PN) for clinical T1b(cT1b) renal cell carcinoma(RCC) .

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

National Trends in the Management of Low and Intermediate Risk Prostate Cancer in the United States

To our knowledge factors affecting the adoption of noncurative initial management in the United States for low risk prostate cancer on a population based level are unknown. We measured temporal trends in the proportion of patients with low and intermediate risk prostate cancer who elected noncurative initial treatment in the United States and analyzed the association of factors affecting management choice.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Are we all doing it wrong? – Influence of stripping and cleaving methods of laser fibers on laser lithotripsy performance

To assess whether stripping and cleaving of the laser-fiber tip with specialized tools, namely, laser-fiber strippers, ceramic scissors, and metal scissors, influence lithotripsy performance.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Superior Functional Outcome after Radical Cystectomy with Orthotopic Bladder Substitution with Restrictive Intraoperative Fluid Management: A Followup Study of a Randomized Clinical Trial

Continuous intraoperative norepinephrine infusion combined with restrictive deferred hydration improves surgical field visibility and significantly decreases intraoperative blood loss and postoperative complications in patients undergoing radical cystectomy and urinary diversion. We determined whether the intraoperative fluid regimen would affect functional results (continence and erectile function) 1 year after orthotopic ileal bladder substitution.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Clinical and Psychological Parameters associated with Pain Pattern Phenotypes in Women with Interstitial Cystitis/Bladder Pain Syndrome

It was recently suggested that 2 distinct clinical phenotypes can be described in patients with urological chronic pelvic pain syndrome, including pelvic pain only and pelvic pain beyond. We examined data on patients with interstitial cystitis/bladder pain syndrome, including body pain location mapping, and associated medical and psychosocial phenotyping to validate these body pain maps in a cohort of female patients with interstitial cystitis/bladder pain syndrome undergoing tertiary care.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

High Quality RNA in Semen and Sperm: Isolation, Analysis and Potential Application in Clinical Testing

Male infertility is a complex health condition. To our knowledge there are no molecular biomarkers of male infertility. Sperm RNA is a potential biomarker for detecting sperm abnormalities and viability at infertility clinics. However, RNA use is hindered by its inconsistent quantity, quality, multiple cell types in semen and condensed sperm structure.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Higher Outcomes of Vasectomy Reversal in Men with the Same Female Partner as Before Vasectomy

We reviewed fertility outcomes of vasectomy reversal at a high surgical volume center in men with the same female partner as before vasectomy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Combined Chemoradiation as Primary Treatment for Invasive Male Urethral Cancer

To evaluate the efficacy and intermediate term outcomes of a combined chemoradiation protocol for the treatment of primary invasive carcinoma of the male urethra.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Evaluation and Comparison of Urolithiasis Scoring Systems in Percutaneous Kidney Stone Surgery

Contemporary predictive tools for percutaneous nephrolithotomy outcomes include the Guy stone score, S.T.O.N.E. nephrolithometry and the CROES nephrolithometric nomogram. We compared each scoring system in the same cohort to determine which was most predictive of surgical outcomes.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Endoscopic Treatment of Symptomatic Vesicoureteral Reflux after Renal Transplantation

We evaluated the success of endoscopic treatment of symptomatic vesicoureteral reflux after renal transplantation and identified factors predicting success.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Comparative analysis of transperineal template-saturation prostate biopsy versus MRI-targeted biopsy with MRI-US fusion-guidance

Multiparametric-MRI (mp-MRI) and MRI-targeted biopsy may improve detection of clinically significant prostate cancer (PCa). However, standardized prospective evaluation is limited.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Improved Outcomes Owing to High Intensity Focused Ultrasound Devices for the Treatment of Patients with Localized Prostate Cancer

To evaluate the association between long-term clinical outcomes and morbidity of high intensity focused ultrasound.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Preoperatively Misclassified, Surgically Removed Benign Renal Masses: A Systematic Review of Surgical Series and United States Population Level Burden Estimate

A significant proportion of renal masses removed for suspected malignancy are histologically benign with the probability inversely proportional to lesion size. To our knowledge the number of preoperatively misclassified benign renal masses treated with nephrectomy is currently unknown. Given the increasing incidence and decreasing average size of renal cell carcinoma, this burden is likely increasing. We estimated the population level burden of surgically removed, preoperatively misclassified benign renal masses in the United States.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Mortality after bladder augmentation in childhood in patients with spina bifida

Renal failure has been a leading cause of death for children with spina bifida (SB). Improvements in management have improved survival, but data on mortality in the modern medical era is sparse. Bladder augmentation, a modern intervention to preserve renal function, carries risks of morbidity and mortality. Our goal is to determine long-term mortality and causes of death in patients with SB and bladder augmentation in the modern era.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

High Regional Variation in Urethroplasty Utilization in the United States

We identified clinical and regional factors associated with the use of urethroplasty vs repeat endoscopic management for urethral stricture disease.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

New Modalities for Evaluation and Surveillance of Complex Renal Cysts

The increased use of abdominal imaging has led to more frequent detection of incidental renal cysts. Since the inception of the Bosniak classification system, management of Bosniak I, III and IV cysts has been clearly defined, while evaluation and management of Bosniak II and IIF cysts have remained a clinical dilemma. Discussions of new imaging modalities are becoming increasingly prevalent in the radiological literature. In this context we performed a comprehensive review of the recent literature on complex renal cysts focusing on new imaging modalities, surveillance strategies and biopsy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Biofeedback for Nonneuropathic Daytime Voiding Disorders in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Biofeedback has been used to treat children with symptoms of bladder dysfunction not responding to standard therapy alone. However, evidence of the effectiveness of biofeedback is scarce and is based on small studies. We conducted a systematic review of the literature to assess the effects of biofeedback as adjunctive therapy for symptoms of nonneuropathic voiding disorders in children up to age 18 years.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Feasibility of Intraoperative Navigation to the Sentinel Node in the Groin Using Preoperatively Acquired Single Photon Emission Computerized Tomography Data: Transferring Functional Imaging to the Operating Room

We explored the clinical feasibility and accuracy of intraoperative navigation based on preoperatively acquired 3-dimensional functional imaging data.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Bladder reinnervation using a primarily motor donor nerve (femoral nerve branches) is functionally superior to using a primarily sensory donor nerve (genitofemoral nerve)

To determine whether transfer of a primarily motor nerve (Femoral, F) to the anterior vesicle branch of the pelvic nerve (PN) allows more effective bladder reinnervation than a primarily sensory nerve (genitofemoral, GF).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Comparison of Transvaginal and Retropubic Bladder Neck Closure with Suprapubic Catheter in Women

Bladder neck closure is an uncommon procedure that is usually reserved for patients with severe urethral incompetence. It may be an acceptable alternative to procedures involving bowel reconstruction. Bladder neck closure can be performed using a transvaginal or a retropubic approach. We compared urethral continence rates, perioperative outcomes, short-term and long-term complications, subsequent procedures and changes in renal function between transvaginal and retropubic bladder neck closure in females at our institution.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prostate Capsule Sparing versus Nerve Sparing Radical Cystectomy for Bladder Cancer: Results of a Randomized, Controlled Trial

Prostate capsule sparing and nerve sparing cystectomies are alternative procedures for bladder cancer that may decrease morbidity while achieving cancer control. However, to our knowledge the comparative effectiveness of these approaches has not been established. We evaluated functional and oncologic outcomes in patients undergoing these procedures.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Donation after Cardiac Death Pediatric En Bloc Renal Transplantation

Use of small pediatric kidneys obtained from extremely young donors after cardiac death has been limited. This potential organ source remains under used by transplant teams.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Prospective, Randomized Comparison of Shock Wave Lithotripsy, Retrograde Intrarenal Surgery and Miniperc for Treatment of 1 to 2 cm Radiolucent Lower Calyceal Renal Calculi: A Single Center Experience

A prospective, randomized comparison of shock wave lithotripsy, retrograde intrarenal surgery and miniperc for the treatment of 1 to 2 cm radiolucent lower calyceal renal calculi was done to evaluate the safety and efficacy of these procedures.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Impact of Family History on Prostate Cancer Mortality in White Men Undergoing Prostate Specific Antigen Based Screening

We assessed whether prostate cancer screening would decrease prostate cancer mortality in white men with a family history of prostate cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reservoir Alternate Surgical Implantation Technique: Preliminary Outcomes of Initial PROPPER Study Patients Consecutively Implanted with Low Profile or Spherical Reservoir in Submuscular Location or Traditional Prevesical Space

Alternative reservoir site placement has become an accepted technique for patients who require an inflatable penile prosthesis. To our knowledge there has been no prospective evaluation of this technique, which is currently off label. We performed a prospective, multicenter, multinational, internal review board approved study to evaluate the effectiveness and safety of alternative reservoir site placement.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Impact of synchronous metastasis distribution on cancer-specific survival in renal cell carcinoma after radical nephrectomy with tumor thrombectomy

Metastatic renal cell carcinoma (RCC) can be clinically diverse in terms of the pattern of metastatic disease and response to treatment. We studied the impact of metastasis and location on cancer-specific survival (CSS).

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prosbiotate: A Multicenter, Prospective Analysis of Infectious Complications after Prostate Biopsy

Prostate biopsy side effects have a role in the controversy over screening for prostate cancer. We measured the precise incidence of infection after prostate biopsy and determined risk factors.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Novel Mathematical Model to Predict Severity of Postoperative Functional Reduction before Partial Nephrectomy: The Importance of Calculating Resected and Ischemized Volume (RAIV)

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Epithelial to Mesenchymal Transition in Penile Squamous Cell Carcinoma

The epithelial to mesenchymal transition (EMT) is a phenomenon observed in epithelial tumors that involves loss of intercellular adhesion, mesenchymal phenotype acquisition and enhanced migratory potential. Whereas the EMT process has been extensively linked to the metastatic progression of the squamous cell carcinoma (SCC), studies on the role of EMT in SCC containing high-risk human papillomaviruses are scarce. Moreover, EMT involvement in human penile squamous cell carcinoma (PSCC), that can arise either through transforming HPV infections or independent to HPV, has not been investigated.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Antegrade Venography Identifies Parallel Venous Duplications in the Majority of Adolescents with Varicocele

We performed intraoperative antegrade venography to assess the prevalence of internal spermatic venous malformations in adolescents with varicocele.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Risk of Urinary Tract Infection after Flexible Cystoscopy in Bladder Tumor Patients who did not receive Prophylactic Antibiotics

To determine the frequency of febrile urinary tract infection (UTI) after outpatient flexible cystoscopy in antibiotic-naïve bladder tumor patients.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

DHH Is an Independent Prognosticator of Oncologic Outcome in Clear Cell Renal Cell Carcinoma

Aberrant HH signaling has proved important in the pathogenesis of several solid cancers. Limited in vitro analyses suggested an oncogenic role for HH in renal cell carcinoma. In this explorative study we sought to validate aberrant HH expression in patients with renal cell carcinoma.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Primary and Reoperative Hypospadias Repair in Adults: Are Results Different than in Children?

There is widespread belief that hypospadias surgery in adults has a greater urethroplasty complication rate than similar repair in children. We compared outcomes of primary and reoperative hypospadias repair in adults vs children.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Sunitinib, Pazopanib or Sorafenib for the Treatment of Patients with Late Relapsing Metastatic Renal Cell Carcinoma

Late recurrence of renal cell carcinoma is not a rare event. In this retrospective study we investigate the clinicopathological features and the outcome of patients treated with sorafenib, sunitinib and pazopanib for late relapsing renal cell carcinoma.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Circulating Serum miRNA (miR-367-3p, miR-371a-3p, miR-372-3p and miR-373-3p) as Biomarkers in Patients with Testicular Germ Cell Cancer

Classic serum tumor markers (human chorionic gonadotropin, α1-fetoprotein and lactate dehydrogenase) have an important role in managing testicular germ cell tumor. Since only 60% of all patients with testicular germ cell tumor have elevations of these markers, there is a need for new biomarkers with greater sensitivity/specificity. miRNAs are deregulated in cancer and could serve as noninvasive serum biomarkers. We explored the role of serum miRNAs as a novel biomarker in patients with testicular germ cell tumor.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Combination of Hemostatic Agents May Safely Replace Deep Medullary Suture during Laparoscopic Partial Nephrectomy in a Pig Model

We assessed whether a combination of the fibrin tissue adhesive Tisseel® (human fibrinogen and thrombin) plus the hemostatic matrix FloSeal® (bovine derived gelatin matrix/human thrombin) could safely replace the conventional deep medullary suture without compromising outcomes.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Bladder Instillation of Liposome Encapsulated OnabotulinumtoxinA Improves Overactive Bladder Symptoms: A Prospective, Multicenter, Double-Blind, Randomized Trial

Cystoscopic intradetrusor injection of botulinum toxin has helped patients with refractory overactive bladder but with the increased risks of urinary tract infection and urinary retention. We assessed whether catheter instillation of 200 U onabotulinumtoxinA formulated with liposomes (lipo-BoNT) is safe and effective for the treatment of overactive bladder.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Lower Urinary Tract Pain and Anterior Urethral Stricture Disease: Prevalence and Effects of Urethral Reconstruction

Anterior urethral stricture disease most commonly presents as urinary obstruction. Lower urinary tract pain is not commonly reported as a presenting symptom. We prospectively characterized lower urinary tract pain in association with urethral stricture disease and assessed the effects of urethroplasty on this pain.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comparison between Spinal and General Anesthesia in Percutaneous Nephrolithotomy

G. Movasseghi, V. Hassani, M. R. Mohaghegh, R. Safaeian, S. Safari, M. M. Zamani and R. Nabizadeh

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Differences in Ureteroscopic Stone Treatment and Outcomes for Distal, Mid-, Proximal, or Multiple Ureteral Locations: The Clinical Research Office of the Endourological Society Ureteroscopy Global Study

E. Perez Castro, P. J. Osther, V. Jinga, H. Razvi, K. G. Stravodimos, K. Parikh, A. R. Kural and J. J. de la Rosette; CROES Ureteroscopy Global Study Group

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Improving the Lens Design and Performance of a Contemporary Electromagnetic Shock Wave Lithotripter

A. Neisius, N. B. Smith, G. Sankin, N. J. Kuntz, J. F. Madden, D. E. Fovargue, S. Mitran, M. E. Lipkin, W. N. Simmons, G. M. Preminger and P. Zhong

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Robotic Intracorporeal Orthotopic Neobladder during Radical Cystectomy in 132 Patients

We present a 2-institution experience with completely intracorporeal robotic orthotopic ileal neobladder after radical cystectomy in 132 patients.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Emergent Care Patterns in Patients with Spina Bifida: A Case-Control Study

Individuals with spina bifida are typically followed closely as outpatients by multidisciplinary teams. However, emergent care of these patients is not well defined. We describe patterns of emergent care in patients with spina bifida and healthy controls.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Improved Split Renal Function after Percutaneous Nephrostomy in Young Adults with Severe Hydronephrosis Due to Ureteropelvic Junction Obstruction

We evaluated percutaneous nephrostomy for adult kidneys with severe hydronephrosis due to ureteropelvic junction obstruction and less than 10% split renal function.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Prospective, Multi-Institutional Study of Flexible Ureteroscopy for Proximal Ureteral Stones Less than 2 cm

Flexible ureteroscopy is rapidly becoming a first line therapy for many patients with renal and ureteral stones. However, current understanding of treatment outcomes in patients with isolated proximal ureteral stones is limited. Therefore, we performed a prospective, multi-institutional study of ureteroscopic management of proximal ureteral stones less than 2 cm to better define clinical outcomes associated with this approach.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Expression of the Tumor Suppressive Cluster Is a Good Prognostic Marker in Clear Cell Renal Cell Carcinoma

We observed abnormal expression of the microRNA-23b/27b (miR-23b/27b) cluster in our previous study of miRNA expression signatures. However, the relationship between aberrant miRNA expression and clear cell renal cell carcinoma is not well established. We investigated the functional significance of the miR-23b/27b cluster in clear cell renal cell carcinoma cells and evaluated these miRNAs as biomarkers to predict the risk of clear cell renal cell carcinoma.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Artificial Urinary Sphincter Placement and Survival in Compromised Urethras: A Comparison of Virgin, Radiated and Reoperative Cases

Although long-term outcomes after initial placement of artificial urinary sphincters are established, limited data exist comparing sphincter survival in patients with compromised urethras (prior radiation, artificial urinary sphincter placement, or urethroplasty). We evaluated artificial urinary sphincter failure in patients with compromised and noncompromised urethras.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Microcirculatory Effects of Selective Endothelin-A Receptor Antagonism in Testicular Torsion

Testicular torsion without timely intervention causes incurable damage to the testis. We examined the causative role of microcirculatory injury in torsion induced testicular damage with particular regard to endothelin-A receptor activation.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Extended Antimicrobial Use in Patients Undergoing Percutaneous Nephrolithotomy and Associated Antibiotic Related Complications

Despite global concern about antibiotic related complications the duration of antibiotic therapy at percutaneous nephrolithotomy varies based on individual physician practice. We evaluated perioperative antibiotic related complications in patients who received extended antimicrobial therapy at percutaneous nephrolithotomy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Histopathological Characteristics of Buccal Mucosa Transplants in Humans after Engraftment to the Urethra: A Prospective Study

Histopathological changes in buccal mucosa transplants after engraftment to the urethra and exposure to urine remain nebulous. We investigated histopathological changes in buccal mucosa transplants integrated into the urethra in humans.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Phase II Trial of Intravesical Nanoparticle Albumin Bound Paclitaxel for the Treatment of Nonmuscle Invasive Urothelial Carcinoma of the Bladder after Bacillus Calmette-Guérin Treatment Failure

Response rates to current second line intravesical therapies for recurrent nonmuscle invasive bladder cancer range between 10% and 30%. Nanoparticle albumin bound (nab-)paclitaxel has increased solubility and lower toxicity compared to other taxanes. Results of the phase I intravesical trial of this compound demonstrated minimal toxicity during dose escalation. We now report the results of a phase II trial to assess efficacy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Transurethral Bladder Tumor Resection Can Cause Seeding of Cancer Cells into the Bloodstream

Transurethral bladder tumor resection is the initial diagnostic procedure for bladder cancer. Hypothetically tumor resection could induce seeding of cancer cells into the circulation and subsequent metastatic disease. In this study we ascertain whether transurethral bladder tumor resection induces measurable seeding of cancer cells into the vascular system.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Intravesical Application of Rebamipide Promotes Urothelial Healing in a Rat Cystitis Model

Rebamipide is used as a topical therapeutic agent for various organs. We examined the healing effects of intravesical rebamipide on damaged urothelium in a rat model of chemically induced cystitis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Effects of Reconstructive Surgery on Bladder Function in Patients with Anorectal Malformations

Bladder dysfunction is common in patients with anorectal malformations and can be congenital or acquired as a consequence of surgery. We investigated the effects of surgical correction of anorectal malformations on bladder function.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A Novel Urine Cytology Stain for the Detection and Monitoring of Bladder Cancer

CellDetect® is a unique platform technology comprising a proprietary plant extract and 3 dyes that enables color discrimination between malignant (red) and benign (green) cells based on specific metabolic alterations exclusive to the former. Preclinical studies and clinical trials demonstrated the applicability of the new technology in many cell culture lines and various cancers. We explored its performance characteristics in bladder cancer.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Thiazide Diuretic Prophylaxis for Kidney Stones and the Risk of Diabetes Mellitus

Thiazide diuretics used to treat hypertension are associated with a modest risk of diabetes mellitus. It is unknown if there is a similar risk with kidney stone prevention.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Meatal Stenosis in Boys following Circumcision for Lichen Sclerosus (Balanitis Xerotica Obliterans)

Of boys circumcised for penile lichen sclerosus, ie balanitis xerotica obliterans, 7% to 19% require late surgery for meatal stenosis. We review the management and outcomes of boys circumcised for lichen sclerosus.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Evaluation of Acute Post-Shock Wave Lithotripsy Renal Changes by Dynamic Magnetic Resonance Imaging: A Prospective Clinical Study

We studied acute renal morphological and hemodynamic changes after shock wave lithotripsy of renal stones.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Ultrasound Guided Ureteroscopy for the Definitive Management of Ureteral Stones: A Randomized, Controlled Trial

Ureteroscopy is central to the surgical management of ureteral stones. Fluoroscopy is conventionally used for intraoperative guidance, although there is growing effort to decrease the exposure of patients and staff to ionizing radiation. We developed a radiation-free approach to ureteroscopy using ultrasound guidance to manage ureteral stones. To our knowledge we present the first randomized trial to study its safety and efficacy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prognostic Value of RASSF1 Promoter Methylation In Prostate Cancer

Patients with prostate cancer who have biochemical recurrence after curative therapy are at higher risk for distant metastasis and cancer specific death. Assessment of aberrant DNA methylation in urine might complement currently used clinical prognostic factors and serve as a noninvasive tool for early prediction of biochemical recurrence after radical prostatectomy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Expression and Role of Leptin under Hypoxic Conditions in Human Testis: Organotypic in Vitro Culture Experiment and Clinical Study on Patients with Varicocele

We investigated the expression and the exact role of leptin under hypoxic conditions in the human testis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Five Year-median Follow-up

Although there is no evidence that testosterone (T) therapy increases risk of prostate cancer (PCa), there is a paucity of long-term data.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

CTR2 Identifies a Population of Cancer Cells with Stem-Like Features in Patients with Clear Cell Renal Cell Carcinoma

In clear cell renal cell carcinoma tissue samples we identified and characterized a population of renal cell carcinoma derived CD133+/CD24+ cancer cells. We studied differences between these cells and their nonneoplastic counterpart, tubular adult renal progenitor cells.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Unintended Negative Consequences of Primary Endoscopic Realignment for Men with Pelvic Fracture Urethral Injuries

We evaluated the clinical course of patients with pelvic fracture urethral injury referred to our institution to elucidate the differences between initial management strategies.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Bladder Biopsy of Normal-Appearing Mucosa Is Not Helpful in Patients with Unexplained Positive Cytology after Nonmuscle Invasive Bladder Cancer

Malignant voided cytology with normal endoscopic evaluation represents a diagnostic and therapeutic challenge in many patients with a history of nonmuscle invasive bladder cancer. Bladder biopsy is often advised but its efficacy is unclear. We evaluated the usefulness of bladder biopsy in patients with unexplained positive cytology and describe recurrence patterns in this unique patient subset.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Grade Heterogeneity in Small Renal Masses: Potential Implications for Renal Mass Biopsy

Understanding the degree of phenotypic heterogeneity in a small renal mass may have implications for interpreting renal mass biopsy data. In this study we quantify nuclear grade heterogeneity in small renal masses.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Completely Intracorporeal Robotic Renal Autotransplantation

We describe a technique of complete intracorporeal renal autotransplantation with donor nephrectomy and transplantation performed in a minimally invasive fashion without extracting the kidney.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Evaluation and Medical Management of Kidney Stones in Children

We review the current literature on the diagnostic evaluation and dietary and pharmacological management of children with nephrolithiasis.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Management of Germ Cell Tumors with Somatic Type Malignancy: Pathological Features, Prognostic Factors and Survival Outcomes

Germ cell tumors with somatic type malignancy are rare, occurring in approximately 2.7% to 8.6% of germ cell tumor cases. Prognostic factors and optimal management remain poorly defined.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prompt Management of Anastomotic Leak or Acute Obstruction after Minimally Invasive Pyeloplasty with Percutaneous Nephrostomy Preserves Outcomes

Urine leak or obstruction in the early postoperative period is a worrisome complication of pyeloplasty. Suboptimal management may risk long-term success. We evaluated percutaneous nephrostomy to manage complications of minimally invasive pyeloplasty.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

DNA Copy Number Variations in Patients with 46,XY Disorders of Sex Development

Less than 50% of cases of 46,XY disorders of sex development are genetically defined after karyotyping and/or sequencing of known causal genes. Since copy number variations are often missed by karyotyping and sequencing, we assessed patients with unexplained 46,XY disorders of sex development using array comparative genomic hybridization for possible disease causing genomic variants.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Cystectomy for Refractory Hemorrhagic Cystitis: Contemporary Etiology, Presentation and Outcomes

We evaluate the clinical presentation, management and outcomes of patients undergoing cystectomy for refractory hemorrhagic cystitis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Open Conversion during Minimally Invasive Radical Prostatectomy: Impact on Perioperative Complications and Predictors from National Data

Despite the increased use of minimally invasive radical prostatectomy, open conversion may occur due to surgical complications, surgeon inexperience or failure to progress. We used nationally representative data to quantify the impact of open conversion compared to nonconverted minimally invasive radical prostatectomy and open radical prostatectomy, and identify predictors of open conversion.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Evaluation of Renal Mass Biopsy Risk Stratification Algorithm for Robotic Partial Nephrectomy—Could a Biopsy Have Guided Management?

We evaluated a published biopsy directed small renal mass management algorithm using a large cohort of patients who underwent robotic partial nephrectomy for tumors 4 cm or smaller.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Anterior Vaginal Wall Suspension Procedure for Moderate Bladder and Uterine Prolapse as a Method of Uterine Preservation

We report our experience with anterior vaginal wall suspension for moderate anterior vaginal compartment prolapse and uterine descent less than stage 2.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

FGFR3 Expression in Primary Invasive Bladder Cancers and Matched Lymph Node Metastases

FGFR3 is considered a good therapeutic target for bladder cancer. However, to our knowledge it is unknown whether the FGFR3 status of primary tumors is a surrogate for related metastases, which must be targeted by FGFR targeted systemic therapies. We assessed FGFR3 protein expression in primary bladder tumors and matched nodal metastases.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Compensatory Hypertrophy after Partial and Radical Nephrectomy in Adults

We assessed compensatory hypertrophy in the contralateral kidney after partial and radical nephrectomy in adults. We also examined predictive factors to facilitate more accurate estimation of global renal function after surgery.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Current Clinical Presentation and Treatment of Localized Prostate Cancer in the United States

SEER recently released patient Gleason scores at biopsy/transurethral resection of the prostate. For the first time this permits accurate assessment of prostate cancer presentation and treatment according to clinical factors at diagnosis.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

An Observational Analysis of Provider Adherence to AUA Guidelines on the Management of Benign Prostatic Hyperplasia

We retrospectively evaluated urologist adherence to the AUA guidelines on the management of new patients with benign prostatic hyperplasia related lower urinary tract symptoms in a large university urology group.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Following the Needles: An Anatomical Study to Evaluate the Postoperative Safety and Symptoms of Patients Receiving a Transobturator Male Sling Implant

Implanting a transobturator male sling is a valid option to manage urinary incontinence after prostatectomy. We evaluated the trajectory of Argus T™ needles blindly introduced into the retropubic space to determine the safety and etiology of postoperative symptoms that can arise from this implant.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Diabetes Mellitus Is Independently Associated with an Increased Risk of Mortality in Patients with Clear Cell Renal Cell Carcinoma

Conflicting data exist on the interaction of diabetes mellitus with outcomes in patients with renal cell carcinoma. We evaluated the association of diabetes mellitus with survival in patients with clear cell renal cell carcinoma treated with nephrectomy.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Risk of Chronic and End Stage Kidney Disease in Patients with Nephrolithiasis

We examine kidney stone disease as a potential risk factor for chronic kidney disease, end stage kidney disease and treatment with dialysis.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prospective Study of Polydimethylsiloxane vs Dextranomer/Hyaluronic Acid Injection for Treatment of Vesicoureteral Reflux

Endoscopic injection of a bulking agent is becoming a first-line treatment for low grade vesicoureteral reflux. We prospectively compared the efficacy of 2 such products commercially available in Canada.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Fluoroquinolone Resistant Rectal Colonization Predicts Risk of Infectious Complications after Transrectal Prostate Biopsy

Infection after transrectal prostate biopsy has become an increasing concern due to fluoroquinolone resistant bacteria. We determined whether colonization identified by rectal culture can identify men at high risk for post-transrectal prostate biopsy infection.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Impact of Complications and Hospital-Free Days on Health Related Quality of Life 1 Year after Radical Cystectomy

We determined the extent to which complications as well as number of hospital-free days within 30 and 90 days of surgery predicted health related quality of life 1 year after radical cystectomy.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Demographics of Pediatric Renal Trauma

There is a lack of national data describing the demographics and nature of pediatric renal trauma. We used the National Trauma Data Bank to analyze mechanisms and grades of injury, demographics and treatment characteristics of pediatric renal trauma cases.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Overlap and Distinction of Self-Reported Symptoms between Interstitial Cystitis/Bladder Pain Syndrome and Overactive Bladder: A Questionnaire Based Analysis

We compared symptoms between interstitial cystitis/bladder pain syndrome and overactive bladder based on patient self-reported symptoms on validated questionnaires.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Safety and Efficacy of a New Adjustable Single Incision Sling for Female Stress Urinary Incontinence

We describe the safety and efficacy of the Altis® Single Incision Sling System for the treatment of female stress urinary incontinence through 12 months.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Comparison of Perioperative Outcomes including Severe Bladder Injury between Monopolar and Bipolar Transurethral Resection of Bladder Tumors: A Population Based Comparison

In this study we used nationwide population based data to compare perioperative outcomes, including severe bladder injury, between monopolar and bipolar transurethral resection of bladder tumors.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Identification of Different Phenotypes of Interstitial Cells in the Upper and Deep Lamina Propria of the Human Bladder Dome

There is increasing evidence for an important role of the lamina propria in bladder physiology and interstitial cells seem to have a key role in this area. Interstitial cells in the upper lamina propria have been studied most frequently. We characterized interstitial cells in the deeper lamina propria and hypothesized that the 2 interstitial cell populations have different phenotypes based on their ultrastructural and immunohistochemical properties.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Beneficial Effects of Renin-Angiotensin System Blockers on Testicular Steroidogenesis

We evaluated whether antihypertensive drugs that act through the renin-angiotensin system would affect testis function.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Surgical Management of Kidney Stone Disease: A Population Based Time Series Analysis

We evaluate population based trends in the use of extracorporeal shock wave lithotripsy, ureteroscopy and percutaneous nephrolithotomy during the last 20 years, as well as assess the re-treatment rate and morbidity from treatment over time.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

A High Throughput, Minimally Invasive, Ultrasound Guided Model for the Study of Catheter Associated Urinary Tract Infections and Device Encrustation in Mice

Catheter associated urinary tract infections are one of the most common health care associated infections. The condition is frequently complicated by encrustation, which blocks the catheter lumen. Preclinical research is limited by the lack of relevant high throughput and cost-effective animal models. Current models are restricted to female mice, associated with major transurethral loss of catheter materials during micturition, highly invasive and complex. We present an ultrasound guided, minimally invasive model that enables catheter associated urinary tract infection and catheter encrustation studies in each mouse gender.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Incidence of Infectious Complications after Extracorporeal Shock Wave Lithotripsy in Patients Without Associated Risk Factors

We determined the incidence of infectious complications (asymptomatic bacteriuria, urinary tract infection and urosepsis) in patients without associated risk factors treated with extracorporeal shock wave lithotripsy.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prospective Evaluation of Magnetic Resonance Imaging Guided In-bore Prostate Biopsy versus Systematic Transrectal Ultrasound Guided Prostate Biopsy in Biopsy Naïve Men with Elevated Prostate Specific Antigen

Magnetic resonance imaging guided biopsy is increasingly performed to diagnose prostate cancer. However, there is a lack of well controlled, prospective trials to support this treatment method. We prospectively compared magnetic resonance imaging guided in-bore biopsy with standard systematic transrectal ultrasound guided biopsy in biopsy naïve men with increased prostate specific antigen.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prospective Trial of the Detection of Urolithiasis on Ultralow Dose (Sub mSv) Noncontrast Computerized Tomography: Direct Comparison against Routine Low Dose Reference Standard

In this prospective trial we compared ultralow dose computerized tomography reconstruction algorithms and routine low dose computerized tomography for detecting urolithiasis.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Low Detectable Prostate Specific Antigen after Radical Prostatectomy—Treat or Watch?

We determined whether the pattern of low detectable prostate specific antigen during the first 3 years of followup after radical prostatectomy would predict subsequent biochemical recurrence.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prospective External Validation of a Bladder Cancer Detection Model

Few studies have combined clinical prognostic factors with urinary biomarkers into risk profiles that can be used to predict the likelihood of bladder cancer. We previously developed and internally validated a bladder cancer detection nomogram that combines clinical features with the NMP22® BladderChek® test. To consider extensive use of the model the nomogram was tested in a prospective cohort of patients who presented with hematuria.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Dietary Intake of Fiber, Fruit and Vegetables Decreases the Risk of Incident Kidney Stones in Women: A Women’s Health Initiative Report

We evaluated the relationship between dietary fiber, fruit and vegetable intake, and the risk of kidney stone formation.

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Evolution of Urethroplasty for Bulbar Urethral Stricture Disease: Lessons Learned from a Single Center Experience

We reviewed the evolution of repairs for bulbar urethral stricture disease and analyzed changes in outcomes.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

The Effect of Stachydrine on the Expression of Caspase-12 in Rats with Unilateral Ureteral Obstruction

We studied the effect of stachydrine on the expression of caspase-12 and 9 in rats with unilateral ureteral obstruction.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Transient Increase in Circulating Myeloid-Derived Suppressor Cells after Partial Bladder Outlet Obstruction

Partial bladder outlet obstruction causes a significant increase in tissue and systemic oxidative stress markers and tissue inflammatory cytokine levels. Myeloid-derived suppressor cells, IFN-γ, IL-10 and aldosterone are believed to be associated with oxidative stress and inflammation. We investigated alterations in plasma myeloid-derived suppressor cells, IFN-γ, IL-10 and aldosterone levels in partial bladder outlet obstruction and after its reversal.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Care Transitions between Hospitals are Associated with Treatment Delay for Patients with Muscle Invasive Bladder Cancer

Hypothesizing that changing hospitals between diagnosis and definitive therapy (care transition) may delay timely treatment, we identified the association between care transitions and a treatment delay of 3 months or greater in patients with muscle invasive bladder cancer.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Unilateral Ureteral Reimplantation and Management of Contralateral Low Grade or Resolved Vesicoureteral Reflux

New contralateral vesicoureteral reflux after unilateral ureteral reimplantation is well described in the literature. Management of high grade vesicoureteral reflux with resolved contralateral reflux is less extensively studied. Most surgeons perform a bilateral procedure in these cases. We report the results when an open procedure was deferred on the contralateral side.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Temporal Pattern of Vesicoureteral Reflux on Voiding Cystourethrogram Correlates with Dynamic Endoscopic Hydrodistention Grade of Ureteral Orifice

The double hydrodistention implantation technique uses ureteral hydrodistention to visualize injection site(s) and determine required bulking agent volume. Along with grade, early vesicoureteral reflux on voiding cystourethrogram provides prognostic information regarding spontaneous resolution of reflux. We hypothesized that reflux timing is predictive of endoscopic hydrodistention grade.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Mechanisms of Pelvic Organ Cross-Talk: Impact of Urethral Ligation on the Inhibitory Rectovesical Reflex

The existence of an inhibitory rectovesical reflex elicited by noxious colorectal afferent input was previously documented in an isovolumetric cystometry model with a ligated urethra. We compared the effect of noxious colorectal distension on bladder cystometry with an open and a ligated urethra.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Survival Analysis of Pure Seminoma at Post-Chemotherapy Retroperitoneal Lymph Node Dissection

Viable seminoma encountered at post-chemotherapy retroperitoneal lymph node dissection for pure testicular seminoma is rare due to the chemosensitivity of this germ cell tumor. In this study we define the natural history of viable seminoma at post-chemotherapy retroperitoneal lymph node dissection.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Efficacy and Safety of Sirolimus for Renal Angiomyolipoma in Patients with Tuberous Sclerosis Complex or Sporadic Lymphangioleiomyomatosis: A Systematic Review

We evaluate the efficacy and safety of sirolimus in the treatment of renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Definition of Biochemical Success Following Primary Whole Gland Prostate Cryoablation

We identified an evidence-based definition of biochemical success following primary whole gland prostate cryoablation.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Cytokine Expression in Patients with Bladder Pain Syndrome/Interstitial Cystitis ESSIC Type 3C

Bladder wall nitric oxide production in patients with bladder pain syndrome type 3C is increased compared to undetectable nitric oxide in patients with nonHunner bladder pain syndrome and healthy controls. However, the underlying mechanism/s of the increased nitric oxide production is largely unknown. We compared mRNA expression of a select group of cytokines in patients with bladder pain syndrome/interstitial cystitis type 3C and in pain-free controls.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Magnetic Resonance Imaging-Ultrasound Fusion Biopsy for Prediction of Final Prostate Pathology

We explored the impact of magnetic resonance imaging-ultrasound fusion prostate biopsy on the prediction of final surgical pathology.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Survival of Men with Prostate Cancer Undergoing Radical Prostatectomy in Ontario

Radical prostatectomy is traditionally reserved for men with at least 10-year life expectancy. Numerous studies show that survival estimates by physicians are inaccurate. We determined how well men undergoing radical prostatectomy for cancer are prognosticated by comparing observed and expected survival.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

GALNT4 Predicts Clinical Outcome in Patients with Clear Cell Renal Cell Carcinoma

We investigated the clinical significance of GALNT4 expression in patients with clear cell renal cell carcinoma.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Glans Preservation Contributes to Postoperative Restoration of Male Sexual Function: A Multicenter Clinical Study of Glans Preserving Surgery

We evaluated whether glans preserving surgery would be more helpful for patients to regain satisfactory sexual competency postoperatively than conventional partial amputation.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Promoter Methylation is Associated with Recurrence in Early Stage Prostate Cancer

Recurrent prostate cancer remains a major problem. Staging, grading and prostate specific antigen level at surgery are helpful but still imperfect predictors of recurrence. For this reason there is an imperative need for additional biomarkers that add to the prediction of currently used prognostic factors.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

von Hippel-Lindau Exonic Methylation Analysis Using MALDI-TOF Mass Spectrometry

Aberrant promoter methylation turns off gene expression and is involved in human malignancy. Studies show that first exon methylation has a tighter association with gene silencing compared to promoter methylation or gene mutation. However, to our knowledge the clinical importance of exonic methylation in renal cell carcinoma is unknown. We analyzed renal cell carcinoma for VHL gene exonic methylation using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Urologists’ Use of Intensity-Modulated Radiation Therapy for Prostate Cancer

J. M. Mitchell

The Journal of Urology (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Comprehensive Geriatric Assessment Can Predict Postoperative Morbidity and Mortality in Elderly Patients Undergoing Elective Surgery

K. I. Kim, K. H. Park, K. H. Koo, H. S. Han and C. H. Kim

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Renal Transplantation after Ex Vivo Normothermic Perfusion: The First Clinical Study

S. A. Hosgood

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Quantification of the Early Risk of Death in Elderly Kidney Transplant Recipients

J. S. Gill, E. Schaeffner, S. Chadban, J. Dong, C. Rose, O. Johnston and J. Gill

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Infection and Inflammation of the Genitourinary Tract

Y. Madani and B. Mann

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Combined ciprofloxacin and amikacin prophylaxis in the prevention of septicaemia after transrectal ultrasound guided biopsy of the prostate

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Purely Transvaginal/Perineal Management of Complications From Commerical Prolapse Kits Using a New Prostheses/Grafts Complication Classification System

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Response to Letter to the Editor

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Sleep Analysis of Patients with Nocturia and Benign Prostatic Obstruction

K. Bal, S. Ayik, Y. Issi, A. Bolukbasi and G. Akhan

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Involvement of Estrogen Receptors in Prostatic Diseases

H. Kawashima and T. Nakatani

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Perioperative outcomes and Oncologic Efficacy from a Pilot Prospective Randomized Clinical Trial of Open Versus Robotic Assisted Radical Cystectomy

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

In Vivo Evaluation of the Third Generation Biodegradable Stent: A Novel Approach to Avoiding the Forgotten Stent Syndrome

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Urodynamis Testing- Is it a Useful Tool in the Management of Children with Cutaneous Stigmata of Occult Spinal Dysraphism?

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Response to Letter to the Editor

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Ureteronenteric Anastomotic Strictures After Radical Cystectomy - Does Operative Approach Matter?

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply to Michael A. Gorin, Arthur I. Sagalowsky and Mark S. Soloway's Letter to the Editor re: S. Picozzi, C. Ricci, M. Gaeta et al. Upper urinary tract recurrence following radical cystectomy for bladder cancer: a meta-analysis on 13,185 patients. J Urol 2012; 188: 2046–54.

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply to Letter to the Editor

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Limitations of Preoperative Biopsy in Patients with Metastatic Renal Cell Carcinoma: Comparison to Surgical Pathology in 405 Cases

To evaluate the ability of preoperative biopsy to identify high-risk pathological features by comparing pathology from preoperative metastatic site and primary tumour biopsies with nephrectomy pathology in patients with metastatic renal cell carcinoma (mRCC).

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Response to "Letter to the Editor"

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Diagnostic Potential of Urinary <alpha>1-Antitrypsin and Apolipoprotein E in the Detection of Bladder Cancer

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Ameliorative Effects of Stinging Nettle (Urtica dioica) on Testosterone-Induced Prostatic Hyperplasia in Rats

A. Nahata and V. K. Dixit

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Persistence of Urgency and Urge Urinary Incontinence in Women with Mixed Urinary Symptoms After Midurethral Slings: A Multivariate Analysis

J. K. Lee, P. L. Dwyer, A. Rosamilia, Y. N. Lim, A. Polyakov and K. Stav

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Managing a Pessary Business

K. O'Dell, L. S. Wooldridge and S. Atnip

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Pessary Care: Follow up and Management of Complications

K. O'Dell and S. Atnip

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Loss of the Urothelial Differentiation Marker FOXA1 is Associated with High Grade, Late Stage Bladder Cancer and Increased Tumor Proliferation

Approximately 50% of patients with muscle-invasive bladder cancer (MIBC) develop metastatic disease, which is almost invariably lethal. However, our understanding of pathways that drive aggressive behavior of MIBC is incomplete. Members of the FOXA subfamily of transcription factors are implicated in normal urogenital development and urologic malignancies. FOXA proteins are implicated in normal urothelial differentiation, but their role in bladder cancer is unknown. We examined FOXA expression in commonly used in vitro models of bladder cancer and in human bladder cancer specimens, and used a novel in vivo tissue recombination system to determine the functional significance of FOXA1 expression in bladder cancer.

The Journal of Urology (2013)

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© 2014 Published by Elsevier Inc. All rights reserved.

Prostatic Fibrosis Is Associated With Lower Urinary Tract Symptoms

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Post-Implantation Alterations of Polypropylene in the Human

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Post-Implantation Alterations of Polypropylene in the Human

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

RE: Long-Term Infection Outcomes of 3-Piece Antibiotic Impregnated Penile Prostheses Used in Replacement Implant Surgery [Letter to the Editor JU-12-1703]

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Response to letter to Editor from Lawrence Klotz re my Editorial Comment on Focal Therapy for Localised Unifocal and Multifocal Prostate Cancer: A Prospective Development Study

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Re: Coated Implants and “No Touch” Surgical Technique Decreases Risk of Infection in Inflatable Penile Prosthesis Implantation to 0.46%

J. F. Eid, S. K. Wilson, M. Cleves and E. A. Salem

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Undescended Testis Histology Correlation with Adult Hormone Levels and Semen Analysis

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Response to Comments: Diagnostic Radiation Exposure Risk in A Contemporary Cohort of Male Patients with Germ Cell Tumor

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Comparative Effectiveness for Survival and Renal Function of Partial and Radical Nephrectomy for Localized Renal Tumors: A Systematic Review and Meta-Analysis

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Reply By Authors: Snodgraft Technıque In The Treatment Of Prımary Dıstal Hypospadıas Repaır: Pushıng The Envelope

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Semen Quality in Men Who Sustained a Spinal Cord Injury During the Prepubertal Period

The Journal of Urology (2012)

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© 2014 Published by Elsevier Inc. All rights reserved.

Editorial Board

The Journal of Urology 192, 5 (2014)

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© 2014 Published by Elsevier Inc. All rights reserved.

Dr Alex Lesani, da vinci robotic surgeon in Las Vegas

6-17-2008.
Dr Lesani performs the first robotic surgery for the removal of kidney tumors in Las Vegas.

11-13-2009. 
Dr Lesani performs a laparoscopic removal of a kidney through a single umbilical incision; the first performed in State of Nevada.