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Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Localized Patients Undergoing Radical Prostatectomy Across Multiple Rare Cell Detection Platforms
Prostate circulating tumor cells escape into the peripheral blood and enter the bone marrow as disseminated tumor cells, representing an early step before conventionally detectable metastasis. It is unclear how frequently this occurs in localized disease, and existing detection methods rely on epithelial markers with low specificity and sensitivity. Here we employed multiple methodologies of disseminated tumor cell detection in bone marrow harvested at radical prostatectomy.
To our knowledge no randomized, prospective trials or prospective trials support the treatment of upper tract CIS. Due to the lack of level 1 evidence it is hard to draw a conclusion about definitive treatment of this relatively rare entity. Most clinical studies have shown the outcome of patients treated with topical and organ conserving therapy for upper tract CIS (reference 9 in article). Due to the small number of patients, the retrospective nature of the study and the varying definitions of upper tract CIS which are mostly based on nonpathological diagnoses, our understanding of upper tract CIS is surrounded by much ambiguity.
Inamoto et al provide one of the largest experiences of upper tract CIS treated with nephroureterectomy, adding to previous reports showing the important biological distinction between upper tract CIS as an isolated, primary entity (p-CIS) vs CIS concomitant with papillary tumors (c-CIS). These findings highlight yet another paradox between the disparate twins1 of bladder and upper tract urothelial cancers whereby p-CIS is associated with favorable survival and a response to BCG (references 6 and 9 to 17 in article) while bladder CIS is considered high risk disease.
Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline. Part II: Recommended Approaches and Details of Specific Care Options
This guideline is structured to provide a clinical framework stratified by cancer severity to facilitate care decisions and guide the specifics of implementing the selected management options. The summary presented herein represents Part II of the two-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline discussing risk stratification and care options by cancer severity. Please refer to Part I for discussion of specific care options and outcome expectations and management.
Long-term outcomes of laser prostatectomy for storage symptoms: Comparison of serial 5-year follow-up data between 120W HPS photo-selective vaporization of the prostate and holmium laser enucleation of the prostate
To compare long-term outcomes for storage symptoms between PVP-120W-HPS and HoLEP, and to find factors influencing postoperative improvement of storage symptoms in the long term.
Neoadjuvant dose dense MVAC versus GC in patients with cT3-4aN0M0 bladder cancer treated with radical cystectomy
Level I evidence supports the utility of neoadjuvant cisplatin-based chemotherapy (NAC) for muscle invasive bladder cancer (BCa). Since dose dense (ddMVAC) has mostly replaced traditional MVAC, we aimed to compare pathological response and survival rates in patients with locally advanced BCa receiving NAC with ddMVAC versus GC.
Re: Post-Chemotherapy Retroperitoneal Teratoma in Nonseminomatous Germ Cell Tumors: Do Predictive Factors Exist? Results from a National Multicenter Study
M. Dusaud, B. Malavaud, Y. Bayoud, P. Sebe, J. L. Hoepffner, L. Salomon, A. Houlgatte, G. Pignot, J. Rigaud, A. Fléchon, C. Pfister, M. Rouprêt, M. Soulié, A. Méjean and X. Durand
S. Sultan, B. Coles and P. Dahm
Re: Functional and Targeted Lymph Node Imaging in Prostate Cancer: Current Status and Future Challenges
H. C. Thoeny, S. Barbieri, J. M. Froehlich, B. Turkbey and P. L. Choyke
Re: Symptomatic Treatment of Uncomplicated Lower Urinary Tract Infections in the Ambulatory Setting: Randomised, Double Blind Trial
A. Kronenberg, L. Bütikofer, A. Odutayo, K. Mühlemann, B. R. da Costa, M. Battaglia, D. N. Meli, P. Frey, A. Limacher, S. Reichenbach and P. Jüni
C. N. Spaulding, R. D. Klein, S. Ruer, A. L. Kau, H. L. Schreiber, Z. T. Cusumano, K. W. Dodson, J. S. Pinkner, D. H. Fremont, J. W. Janetka, H. Remaut, J. I. Gordon and S. J. Hultgren
Re: Validation Study of the SCREENIVF: An Instrument to Screen Women or Men on Risk for Emotional Maladjustment before the Start of a Fertility Treatment
H. D. L. Ockhuijsen, M. van Smeden, A. van den Hoogen and J. Boivin
K. Rotker, H. Vigneswaran, D. Omil-Lima, M. Sigman and K. Hwang
Re: Effect of Cranial Irradiation on Sperm Concentration of Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report from the St. Jude Lifetime Cohort Study
D. M. Green, L. Zhu, M. Wang, W. Chemaitilly, D. Srivastava, W. H. Kutteh, R. W. Ke, C. A. Sklar, C. H. Pui, L. E. Kun, R. C. Ribeiro, L. L. Robison and M. M. Hudson
L. F. Sávio, J. Palmer, N. S. Prakash, R. Clavijo, D. Adamu and R. Ramasamy
Re: Fertility Outcomes after Extended Searches for Ejaculated Spermatozoa in Men with Virtual Azoospermia
N. Miller, T. Biron-Shental, Y. Pasternak, M. Belenky, S. Shefi, P. Itsykson and A. Berkovitz
P. H. Chung, J. A. Siegel, T. J. Tausch, A. K. Klein, J. M. Scott and A. F. Morey
Re: Transobturator Sling for Post-Prostatectomy Incontinence: Radiation’s Effect on Efficacy/Satisfaction
H. C. Wright, K. McGeagh, L. A. Richter, J. J. Hwang, K. Venkatesan, A. Pysher, G. E. Koch, K. Kowalczyk, G. Bandi and D. Marchalik
Re: Outcomes of Urethroplasty to Treat Urethral Strictures Arising from Artificial Urinary Sphincter Erosions and Rates of Subsequent Device Replacement
S. Keihani, J. C. Chandrapal, A. C. Peterson, J. A. Broghammer, N. Chertack, S. P. Elliott, K. F. Rourke, N. F. Alsikafi, J. C. Buckley, B. N. Breyer, T. G. Smith, III, B. B. Voelzke, L. C. Zhao, W. O. Brant and J. B. Myers; Trauma and Urologic Reconstruction Network of Surgeons (TURNS, TURNSresearch.org)